Karl-Josef Langen

Prof. Karl-Josef Langen is a Group Leader at the Institute of Neuroscience and Medicine (INM) within the Physics of Medical Imaging (INM-4) department at the Forschungszentrum Jülich. His work focuses on advancing neuroimaging techniques for brain tumor diagnostics, particularly using 18F-FET PET and multimodal imaging approaches. His research addresses challenges in distinguishing tumor recurrence from treatment-related effects, improving survival predictions, and optimizing therapeutic strategies in glioma patients.

Key areas of expertise include neuro-oncological imaging, radiomics, functional connectivity analysis, and clinical trial design. He leads projects integrating machine learning for automated tumor segmentation and has contributed to international guidelines for PET/MRI applications in neuro-oncology. His team collaborates across disciplines to develop innovative imaging protocols and predictive biomarkers for personalized cancer care.

Recent studies emphasize cost-effectiveness analyses of imaging modalities, validation of imaging algorithms, and preclinical model development. His work directly impacts clinical decision-making through multidisciplinary tumor boards and has implications for global neuroimaging standards.