Joshua T Mattila

Joshua T Mattila is an Associate Professor at the University of Pittsburgh in the Department of Infectious Diseases and Microbiology, with a focus on tuberculosis (TB) and HIV-TB coinfection. His work integrates experimental and computational approaches to study granuloma biology, macrophage responses, and immune cell interactions in TB pathogenesis.

• Education: B.S. in Biology (1992-1996, Bemidji State University); Ph.D. in Entomology (1999-2006, University of Minnesota); Postdoctoral Training in TB Immunology (2007-2013, University of Pittsburgh)

Research interests include:

• Macrophage cytokine signaling and arginine metabolism in granulomas
• Neutrophil dual roles in TB pathology and protection
• Computational modeling of granuloma dynamics (GranSim)
• HIV-induced immune dysregulation in TB

His publications highlight collaborations with leading TB researchers and emphasize systems biology, imaging, and cellular interactions. Teaching roles span topics like pathogen biology, computational modeling, and global TB control. Current projects aim to improve TB treatment in HIV-coinfected individuals through pharmacological and immunological insights.