Martin Rottenberg

Professor Martin Rottenberg is a leading immunologist at Karolinska Institutet, affiliated with the Department of Microbiology, Tumor and Cell Biology. He leads the Intracellular Mycobacterium Tuberculosis group, focusing on immune mechanisms controlling tuberculosis (TB) and parasitic infections. His research emphasizes T-cell and macrophage interactions in granuloma formation, hypoxia responses (HIF-1α), and diabetes-TB co-morbidity. Key projects include spatial transcriptomics of TB granulomas and HIF-1α regulation in T cells.

Research interests span immunology, microbiology, and infectious disease pathogenesis. His work bridges basic science and clinical applications, such as vaccine development and biomarker identification (e.g., the Actigraphy Sleep Score for trypanosomiasis). Major funding includes over 49 million SEK from the Swedish Research Council (2023).

Recent publications highlight granuloma spatial mapping, HIF-1α’s role in TB control, and SOCS3’s impact on immune regulation. Collaborations include teams at Karolinska Institutet and international partners in vaccine trials and disease modeling.