Jonathan Schug

Jonathan Schug is an Adjunct Assistant Professor of Genetics and Technical Director of the Next-Generation Sequencing Core and Functional Genomics Core at the University of Pennsylvania. He is affiliated with the Perelman School of Medicine and serves as a bioinformatics partner for the Institute for Diabetes and Metabolism (IDOM) Diabetes Research Center (DRC).

• BA in Mathematics (University of Pennsylvania, 1980)
• MSE in Computer and Information Science (University of Pennsylvania, 1995)
• PhD in Computer and Information Science (University of Pennsylvania, 2005)

Dr. Schug specializes in bioinformatics, genomics, and computational biology, with research spanning diabetes, neuroscience, and epigenetics. His work includes developing tools like Defiant for methylation analysis and applying sequencing technologies to study metabolic diseases and neurodegenerative conditions.

Recent publications highlight his contributions to single-cell RNA-seq, mass cytometry, and sequencing platform comparisons. He collaborates extensively on projects involving Alzheimer's disease, Traumatic brain injury, and insulin-producing cell engineering.

Dr. Schug provides technical leadership for high-throughput sequencing services and bioinformatics support at Penn, overseeing experimental design, library preparation, and data analysis pipelines.