John Rouse

John Rouse is a Professor and Scientific Programme Leader (MRC) of Chromosome Biology at the MRC PPU. His research focuses on DNA repair mechanisms, chromatin structure, and genome maintenance. He leads projects funded by the Medical Research Council (MRC) and other institutions, including collaborative efforts on chromatin remodelling and DNA interstrand crosslink repair.

• Key roles: MRC QQR Programme Leader (2018–2024), Investigator on multiple collaborative grants.
• Research interests: Chromosome biology, DNA damage response, histone chaperones, and kinase signaling pathways.

His work contributes to understanding genome integrity and has implications for cancer therapy and neurodegenerative diseases. Notable projects include the study of NEK1 kinase in ALS and the development of targeted cancer therapies using PROTAC technology.

John has been involved in public engagement activities, such as the Discovery Days 2012 event, promoting science outreach.