Hongda Huang

Dr. Hongda Huang is an Associate Professor in the Department of Biology at Southern University of Science and Technology (SUSTech) in Shenzhen, China. He joined SUSTech in 2017 after completing his postdoctoral training at Memorial Sloan-Kettering Cancer Center in New York. His academic career spans structural biology and epigenetic research, with a focus on understanding molecular mechanisms of genome regulation.

Education:

• PhD in Structural Biology (2004-2010), University of Science & Technology of China
• BS in Biological Sciences (2000-2004), University of Science & Technology of China

Dr. Huang's research primarily focuses on epigenetic regulation of the eukaryotic genome through structural biology and biochemistry techniques. His work examines DNA methylation (including DNA methyltransferases, demethylases and reader modules), histone modifications (methylation, acetylation, phosphorylation, ubiquitination), chromatin remodeling, histone variants (particularly H2A and H3), and histone chaperones. These epigenetic mechanisms influence gene transcription, DNA replication, DNA repair, and cell development, with dysfunctions potentially leading to human diseases including cancer.

Dr. Huang's publication record demonstrates consistent contributions to structural biology, particularly in determining the molecular structures of protein complexes involved in epigenetic regulation, DNA repair, and chromosome dynamics. His work frequently appears in high-impact journals including Nature, Nature Structural & Molecular Biology, and Cell Research, showing expertise in X-ray crystallography and NMR spectroscopy techniques applied to understand fundamental biological processes at the molecular level.

As an active research professor at SUSTech's School of Life Sciences, Dr. Huang maintains a laboratory focused on epigenetics and structural biology. His collaborative publications with international researchers indicate integration into global scientific networks and suggest successful funding for his research program. His work has particular relevance for understanding disease mechanisms and potentially developing therapeutic approaches targeting epigenetic regulators.