John Castle

John Castle is a Researcher at the Division of Cancer Sciences, University of Manchester, based at the Manchester Cancer Research Centre. His research focuses on the symbiotic relationship between cancer and clotting systems, exploring how cancer promotes clotting and vice versa. He investigates systemic and tissue biomarkers of hypercoagulability in breast and colorectal cancers through studies like WiSDen, CHAMPion, T-POETIC, TuFClot, and the TIP Trial.

Key collaborations include Prof. Cliona Kirwan (Supervisor), Prof. Robert Clarke, and Prof. Caroline Dive. Team members include Dr. Emma Blower, Ms. Urvashi Singh, and others. His work contributes to UN Sustainable Development Goal 3 (Good Health and Well-being).

Research emphasizes cancer stem cells, tumor microenvironment, and clinical trials targeting coagulation pathways. Recent articles highlight coagulation factors in colorectal cancer, endothelial cell interactions in breast cancer, and the role of circulating tumor cells in thrombosis.

No awards are explicitly listed, though his work has garnered significant readership (e.g., 28 citations for a 2022 study). He contributes to datasets like the TuFClot Study and collaborates on drug trials like the TIP Trial.