About
Jayne Raper is a Professor in the Department of Biological Sciences at Hunter College, CUNY, focusing on trypanosome lytic factors (TLFs) and their role in primate innate immunity. Her research explores the molecular mechanisms of antimicrobial high-density lipoproteins, particularly how TLFs kill African trypanosomes through proteins like apolipoprotein L-I (apoL-I) and haptoglobin-related protein (Hpr).
Education:
- BSc (1982), University of Newcastle Upon Tyne
- PhD (1989), University of Cambridge
- Postdoctoral training at Johns Hopkins School of Medicine (1989-1993) and the de Duve Institute, Belgium (1993-1995)
Recent research highlights include the structural and functional characterization of APOL1 variants, their role in cytotoxicity and resistance to trypanosomes, and the evolution of primate-specific TLF components. Her work has implications for understanding innate immunity, host-pathogen coevolution, and potential therapeutic applications.
Laboratory:
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