Jason Haugh

Jason Haugh is a Professor in the Department of Chemical and Biomolecular Engineering at North Carolina State University, part of the College of Engineering. His research focuses on signal transduction networks, particularly how cells integrate molecular signals to regulate survival, proliferation, and migration. Key areas include molecular crosstalk in pro- and anti-apoptotic pathways, spatial sensing of chemical gradients, and actomyosin dynamics in directed cell migration. His interdisciplinary approach combines mathematical modeling, live-cell fluorescence microscopy (e.g., TIRFM), and biochemical assays to study signaling mechanisms in fibroblasts and T cells, with applications to wound healing and cancer biology.

Haugh’s lab investigates how cells respond to stimuli like PDGF and interleukin-2/4, elucidating crosstalk between pathways such as PI3K, MAPK, and Rho GTPases. Recent work highlights roles of CD44, Ezrin, and actin dynamics in bleb-based migration, while microfluidic platforms enable precise chemotaxis studies. Publications emphasize quantitative analysis of signaling kinetics, spatial patterns, and emergent behaviors in cellular systems. The lab’s findings inform therapeutic strategies for tissue repair and cancer intervention.