Jason Butler

Jason Butler is a Professor and Vice Chief of Research in the Division of Hematology/Oncology at the University of Florida College of Medicine. His work focuses on understanding the vascular niche’s role in hematopoietic stem cell (HSC) maintenance, aging, and disease. Key research areas include rejuvenating aged HSCs, studying Sickle Cell Disease’s impact on bone marrow niches, and developing endothelial-based therapies. Contact: j8338@ufl.edu, PO Box 100278, Gainesville FL 32610.

Research interests emphasize vascular interactions with HSCs, leveraging mouse models and single-cell transcriptomics to engineer functional niches. Recent studies explore CRISPR-based vulnerabilities in leukemic cells and mechanisms of niche dysfunction in aging. His work bridges basic science and translational medicine, with implications for regenerative therapies and cancer treatment.

Publications highlight breakthroughs in HSC homing, niche rejuvenation, and therapeutic applications of endothelial signaling. While no formal advisees are listed, his lab collaborates widely on projects involving hematopoiesis and vascular biology. Grants and funding details are not explicitly detailed in the provided text.