Jacob Geri

Jacob Geri is an Assistant Professor in the Department of Pharmacology at Weill Cornell Medical College. His multidisciplinary research integrates chemical biology, proteomics, and advanced microscopy to develop proximity-labeling technologies (μMap platform) for mapping disease-relevant protein interactions.

Education:

• PhD (2018) - University of Michigan
• BS (2012) - Stetson University

Research Focus: The Geri Lab pioneers optically controlled proximity labeling methods to study transient protein interactions driving cancer, immunology, and infectious diseases. Key areas include: high-throughput screening, chemical probe development, mass spectrometry, and cellular imaging. Research integrates chemical synthesis, photochemistry, and molecular biology to identify therapeutic targets.

Publication Trends: Recent articles (2022-2025) demonstrate his development of the μMap platform for applications including: drug target identification, host-pathogen interactions, cancer surfaceome mapping, and tissue diagnostics. This work consistently bridges chemical tool development with biological discovery in disease mechanisms.

Grants and Funding:

• Principal Investigator: 'Optically Gated Discovery of Protein-Biomolecule Interactions' (NIGMS, 2022-2027)
• Principal Investigator: 'Elucidating the resistant leukemia stem cell niche' (Starr Consortium, 2024-2026)
• Co-PI: '4D proteomics for pancreatic cancer detection' (NCI, 2023-2028)

Lab Activities: The lab focuses on technology development for spatially resolved proteomics, collaborating across disciplines to apply these tools in cancer, immunology, and infectious disease contexts. Future work emphasizes clinical translation of proximity labeling for tissue diagnostics.