George Holzwarth

George Holzwarth is a Research Professor in the Department of Physics at Wake Forest University. His research focuses on molecular motors, intracellular mechanics, and advanced microscopy techniques such as MEDIC and PM-DIC. He explores how motor proteins like kinesin transport vesicles within live cells and their roles in cancer metastasis. Current projects include studying cell mechanical properties in 3D collagen matrices and developing Bayesian analysis methods for particle tracks.

Education: B.A. Physics (Wesleyan University 1959), M.S. Medical Sciences (Harvard 1961), Ph.D. Biophysics (Harvard 1964), Postdoc (Florida State University 1965-67).

Research Interests:

• Mechanical properties of live cells in 2D/3D culture
• Motor-driven vesicle transport dynamics
• Polarization-modulated DIC microscopy innovations
• Bayesian analysis of intracellular particle motion

Publications: Recent work includes studies on cancer cell mechanics (2015), motor coordination (2011), and MEDIC microscopy (2008). His publications span molecular motor mechanics, imaging advancements, and cytoplasmic biophysics.

Awards: NIH Research Career Development Award (1971-74). Patents: Oil recovery technologies and electrophoresis methods.

Labs/Teams: Leads interdisciplinary biophysics research group, collaborating with chemists and biomedical engineers on cell mechanics and microscopy development.