Frederick Maxfield

Frederick Maxfield, PhD is a Professor of Biochemistry and Biophysics at Weill Cornell Medical College. His research focuses on developing advanced optical microscopy and biophysical techniques to study cellular cholesterol metabolism, particularly in macrophages and microglia, with implications for atherosclerosis and neurodegenerative diseases like Alzheimer's.

• Education:
  • PhD, Cornell University (1977)
  • MS, Cornell University (1973)
  • BS, Union College (1971)

Key research areas include cholesterol transport, lysosomal function, and macrophage biology, with recent work on extracellular amyloid-beta degradation and sterol trafficking proteins. His lab employs high-content microscopy and fluorescent probes to investigate these processes.

Current projects examine novel therapeutic approaches for Niemann-Pick type C disease and mechanisms of digestive exophagy in lipid metabolism. Grants from the National Heart, Lung, and Blood Institute and American Heart Association support this work.

External Relationships:

• Consultant, Amlogenyx Inc.
• Leadership Role, Burke Neurological Institute
• Ownership Interest, Amlogenyx Inc.