Joyce Repa

Joyce Repa is a Professor at the Department of Physiology, UT Southwestern Medical Center, with a focus on nuclear receptor regulation of gene expression in metabolic and neurodegenerative diseases. Her research spans lipid and carbohydrate metabolism in the liver, intestine, pancreatic islets, and central nervous system, utilizing transcriptomics, lipidomics, and mouse models.

• Key Research Areas: Nuclear receptor biology, cholesterol homeostasis, NPC disease, diabetes, atherosclerosis
• Methodologies: Transcriptomics, lipidomics, mouse models, cell-based assays

Her work highlights the role of nuclear hormone receptors in metabolic diseases and neurodegeneration, including the therapeutic potential of cyclodextrin for Niemann-Pick Type C (NPC) disease. Recent studies explore hearing loss in NPC and cholesterol efflux mechanisms. Despite no explicit awards listed, her extensive publication record underscores significant contributions to molecular physiology and metabolic research.