Fen Long

Dr. Fen Long is a Researcher affiliated with the Professorship for Translational Nutrition Biology at ETH Zürich. Their work focuses on metabolic disorders, nutritional physiology, and molecular mechanisms underlying metabolic diseases. Key research interests include histone modifications, inflammation, and their roles in cardiovascular and metabolic pathologies.

Dr. Long’s research integrates genomic approaches (e.g., single-nucleus transcriptomics) with biochemical studies to dissect mechanisms of obesity, insulin resistance, and vascular dysfunction. Recent studies highlight their expertise in epigenetic regulators like JMJD3 and SMYD3, linking histone modifications to fibrosis, inflammation, and autoimmune responses. They also investigate dietary interventions (e.g., low-carbohydrate diets) and pharmacological targets (e.g., histone methyltransferase inhibitors) in metabolic and cardiovascular contexts.

Publications span metabolic signaling (e.g., glucagon, cAMP/PKA pathways), lipid metabolism (ATGL regulation), and cellular stress responses (unfolded protein response). Their work bridges basic molecular mechanisms to translational applications in therapies for metabolic-associated fatty liver disease, rheumatoid arthritis, and post-myocardial infarction recovery.

No scientific awards or current advising roles are explicitly listed. Their research is conducted within the Translational Nutrition Biology group at ETH Zürich, leveraging interdisciplinary collaborations in systems biology and clinical translation.