About
François Pagniez is an Associate Professor at the University of Nantes, affiliated with the Department of Medicinal Chemistry. His research focuses on the discovery and development of antifungal and antiparasitic agents, particularly targeting pathogenic fungi like Candida and Aspergillus, as well as parasitic organisms such as Leishmania. He leads efforts in synthetic chemistry, drug design, and mechanisms of drug resistance. His work integrates molecular biology approaches (e.g., CRISPR-Cas9) and material science innovations (e.g., drug-loaded nanoparticles).
Education:
- PhD in Chemistry (2001): Thesis on the evaluation of azolybenzylindole derivatives as antileishmanial and antifungal agents.
Research Interests:
- Development of novel antifungal and antiparasitic compounds with a focus on azole derivatives, imidazo[1,2-a]pyrazines, and organometallic agents.
- Mechanisms of drug resistance in fungal pathogens, including ergosterol biosynthesis pathways and transcription factor regulation.
- Targeted drug delivery systems, such as nanoparticle formulations and molecularly imprinted textiles.
Grants & Collaborations:
- Involved in ANR-funded projects like TEILEISH and AspergillusOne-Health.
- Collaborations with institutions like INSERM and international labs (e.g., for organometallic drug discovery).
Labs & Teams:
- Member of the Department of Medicinal Chemistry at the University of Nantes, contributing to interdisciplinary research on One Health approaches and new therapeutic targets.
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