Elisabeth LETELLIER

Elisabeth Letellier is an Assistant Professor at the University of Luxembourg's Faculty of Science, Technology and Medicine (FSTM), leading the Molecular Disease Mechanisms group within the Department of Life Sciences and Medicine. Her research focuses on dissecting molecular mechanisms underlying colorectal cancer (CRC) progression, drug resistance, and tumor microenvironment interactions. She collaborates with institutions like the Integrated BioBank of Luxembourg (IBBL) and Laboratoire National de la Santé (LNS) to develop patient-derived 3D tumor models and in vivo systems for translational research. With over 40 publications (H-index 27, 3196 citations) and securing €9M in competitive grants since 2013, her work also includes contributions to three patents, two as primary author.

Research interests include metabolic reprogramming in tumor cells, microbiome-driven cancer progression, and stromal cell interactions. She teaches molecular medicine in the Master in Molecular and Computational Biomedicine program, emphasizing protein structure and biochemistry practical training.

Her team's achievements include collecting over 180 high-quality CRC patient samples and advancing drug repurposing strategies targeting KRAS/BRAF mutations. Current projects explore formate-driven metastasis mechanisms, ketogenic diet effects, and gut microbiome modulation in cancer therapy.