Edward Yu

Edward Yu is a Professor in the Department of Pharmacology at Case Western Reserve University School of Medicine. He is also a member of the Cleveland Center for Membrane & Structural Biology, focusing on structural biology of membrane transporters and bacterial resistance mechanisms.

• Institution: Case Western Reserve University
• Department: Pharmacology
• Research Center: Cleveland Center for Membrane & Structural Biology

Yu's research centers on the structure, assembly, and mechanism of resistance-nodulation-cell division (RND) superfamily efflux pumps, which enable Gram-negative pathogens to survive toxic environments by extruding antimicrobial agents. His lab has determined crystal structures of key systems like the CusCFBA heavy-metal efflux complex and cell wall remodeling transporters HpnN (Burkholderia) and MmpL3 (Mycobacterium), published in high-impact journals like Nature and PNAS.

He pioneered the "Build and Retrieve" (BaR) cryo-EM methodology for studying membrane proteomes from heterogeneous samples, enabling near-atomic resolution insights into biological networks. His work spans bacterial resistance, membrane transporter regulation, and structural-omics approaches, with implications for understanding human interactomes.