Dominik Froehlich

Dr Dominik Froehlich is a Researcher at the School of Biomedical Sciences, UNSW Sydney, where he leads the CNS Gene Therapy group within the Translational Neuroscience Facility. His work focuses on developing gene therapies for neurodegenerative disorders like leukodystrophies, dementias, and hereditary spastic paraplegias.

• PhD (Johannes Gutenberg University Mainz, Summa cum laude, 2014)
• MSc (Johannes Gutenberg University Mainz, with distinction, 2009)

His research program has two pillars:

• Creation/characterization of genetic disease models to understand pathophysiology
• Pre-clinical testing of AAV-mediated gene therapies targeting CNS cell types

Current projects include:

• Moon's Mission (MRFF, 2023-2025): Therapeutic framework for hereditary spastic paraplegias
• Understanding oligodendroglial dysfunction (NHMRC Ideas Grant, 2023-2026)

He serves on the UNSW Animal Care and Ethics Committee and contributes to scientific advocacy through Leukodystrophy Australia and the Mission Massimo Foundation.