Dean E. Wilcox

Dean E. Wilcox is a Professor of Chemistry at Dartmouth College, specializing in inorganic and bioinorganic chemistry. His research focuses on the spectroscopy, thermodynamics, and coordination chemistry of transition metal ions in biological systems.

• B.S. and M.S. from the University of California at Riverside
• Ph.D. from the Massachusetts Institute of Technology

Research interests include:

• Stability and spectroscopy of transition metal ions in proteins (e.g., hemocyanin, tyrosinase)
• Metal-dependent folding of proteins like zinc fingers and metallothionein
• Thermodynamic analysis using isothermal titration calorimetry (ITC)
• Electron paramagnetic resonance (EPR) studies of metalloenzymes
• Metal transport and binding in biological systems
• Reaction mechanisms of hydrolytic metalloenzymes (e.g., urease)

Recent publications highlight thermodynamic and coordination chemistry analyses of metal-substituted enzymes, insulin hexamer assembly, and organophosphate-degrading enzymes. His work integrates biochemical and physical chemistry approaches to elucidate metal ion roles in biological processes.

Contact: Dean.E.Wilcox@dartmouth.edu | Phone: 603-646-2874 | Office: Burke Room 113, HB 6128