David C. Spray

David C. Spray is a Professor at the Albert Einstein College of Medicine, holding joint appointments in the Dominick P. Purpura Department of Neuroscience and the Department of Medicine (Cardiology). He is based in the Bronx, NY. His research focuses on the roles of gap junctions in excitable and inexcitable cells, including their physiological and molecular functions. Key projects include studying gap junctions in orofacial pain models, connexin-protein interactions, stem cell therapy in Chagas disease, and osteocyte mechanotransduction in blood-brain-barrier models.

His research employs advanced techniques such as intracellular recordings, FRAP, patch clamp, and molecular biology methods like RT-PCR and microarrays. Collaborations include work with biomedical engineers from CCNY and pathologists on stem cell therapies. Recent publications highlight contributions to autophagosome regulation, Chagas disease therapy, and mechanosensory processes in osteocytes.

No scientific awards are explicitly mentioned, but his work spans interdisciplinary projects addressing cellular communication and disease mechanisms. His lab integrates cell biology, neuroscience, and biomedical engineering to advance understanding of gap junction dynamics and their clinical applications.