David Barbie

David Barbie is an Associate Professor of Medicine at Harvard Medical School, affiliated with the Dana Farber Cancer Institute. His research focuses on cancer innate immunity and the development of novel immunotherapies.

Key research areas include:

• Targeting defects in tumor innate immunity to improve immunotherapy response
• Engineering microfluidic ex vivo platforms for modeling cancer immunotherapy
• Combining epigenetic inhibitors with STING agonists in immune-suppressive cancers
• Investigating KRAS-LKB1 mutations and their role in immune evasion
• Developing high-resolution methods for analyzing tumor microenvironment dynamics

Laboratory efforts also incorporate organism models using human and mouse systems to validate therapeutic strategies.