Daniel Dominguez

Daniel Dominguez is an Assistant Professor in the Department of Pharmacology at the University of North Carolina at Chapel Hill School of of Medicine and a member of the Lineberger Comprehensive Cancer Center.

His research focuses on RNA-protein interactions in gene regulation, with three core areas:

• Altered RNA-protein interactions in cancer, investigating how mutations in RNA binding proteins or target RNA sequences drive cancer-specific processing defects
• RNA binding by noncanonical domains and disordered regions, exploring implications for normal and aberrant RNA biology
• Crosstalk between cell signaling pathways and RNA processing, studying post-translational modifications of RNA binding proteins and drug response mechanisms

The Dominguez Lab integrates experimental and computational approaches: high-throughput biochemical techniques (in vitro and in vivo), cell-based drug response assays, and computational analysis of RNA sequencing data to study aberrant splicing in cancer, RNA binding specificities, and regulatory program-drug relationships.

No scientific awards were documented in the source material.

The lab actively recruits graduate students, postdoctoral researchers, research technicians, and undergraduate students for projects spanning RNA biology and cancer mechanisms, with prospective postdocs required to submit research statements and CVs.

Based in the Genetic Medicine Building, the Dominguez Lab maintains a multidisciplinary team focused on RNA processing mechanisms in disease contexts through integrated biochemical and bioinformatic workflows.