Claire Booth

Claire Booth is Professor of Gene Therapy and Paediatric Immunology within the Infection, Immunity & Inflammation Department at University College London. Her work bridges cutting-edge gene therapy techniques with clinical applications for pediatric immunodeficiency disorders, focusing on translating laboratory discoveries into therapeutic interventions for rare genetic conditions.

Education:

• Doctor of Philosophy, University College London (2012)
• Master of Science, University College London (2007)
• Bachelor of Medicine/Bachelor of Surgery, King's College London (2001)

Professor Booth's research centers on gene therapy approaches for inborn errors of immunity, with particular expertise in lentiviral vector systems, hematopoietic stem cell gene therapy, and genome editing techniques. Her work addresses critical challenges in treating rare immunodeficiency disorders including X-linked SCID, Fanconi anemia, leukocyte adhesion deficiency, and CTLA4 insufficiency. She investigates both the mechanistic underpinnings of these disorders and the development of novel therapeutic strategies that can be translated to clinical practice.

Analysis of her recent publications (2023-2024) reveals a strong focus on clinical translation of gene therapy approaches, with numerous phase 1/2 clinical trial results, methodological improvements in conditioning regimens, and exploration of novel targets for immunodeficiency disorders. Her work spans basic science investigations through to clinical implementation, with particular attention to safety profiles, immune reconstitution patterns, and long-term outcomes in pediatric patients.

Professor Booth actively collaborates with international research groups and clinical networks, contributing to consensus guidelines for managing rare immunological conditions. Her research program addresses critical gaps in understanding how to effectively deliver gene therapies for rare diseases while navigating the complex challenges of commercialization and accessibility.