Christelle Orlando

Christelle Orlando serves as an Unpaid guest professor (mapped to Visiting Professor) in the School of Clinical Sciences and Researcher in Clinical Biology at Vrije Universiteit Brussel, with continuous scientific collaboration at Universitair Ziekenhuis Brussel's Hemostasis lab since 2005. She oversees routine and specialized coagulation testing while contributing to translational research through the Translational Oncology Research Center affiliation.

Her academic credentials include a Master's degree in Medical Sciences (2005) and PhD in Medical Sciences (2021), both from Vrije Universiteit Brussel, focusing on minimal residual disease detection in pediatric leukemia and novel insights into inherited antithrombin deficiency respectively.

Dr. Orlando's research centers on inherited thrombophilia, with specialized expertise in antithrombin deficiency mechanisms and diagnostics. She investigates genotype-phenotype correlations in coagulation disorders, develops laboratory validation protocols, and examines clinical implications of rare mutations like the Budapest 3 variant. Her work bridges molecular pathology with clinical hemostasis practice through rigorous diagnostic assay evaluation.

Recent publications demonstrate evolving expertise from case-based mutation analysis toward comprehensive diagnostic methodology. Her 2024-2025 work shows increasing emphasis on analytical validation of hemostasis instruments and standardization of antithrombin testing, reflecting field-wide shifts toward precision diagnostics in thrombophilia.

Her contributions have earned significant recognition:

• Paul Capel Prize (2010 and 2011)
• Prijs Edmond Secq en André Houssiau 2022 for inherited bleeding disorders research (awarded 2023)

Dr. Orlando actively mentors next-generation researchers, supervising Master's theses like Bouteille, S.P.'s 2022 work on protein C deficiency genotype-phenotype correlations. Her professional engagements include conference chairing (Werfen SAC Meeting Benelux 2024), invited lectures on thrombophilia testing standardization, and peer review for Haemophilia journal, demonstrating leadership in hemostasis education and quality assurance.

Within UZ Brussel's Hemostasis lab, she leads specialized coagulation testing initiatives while collaborating with the Translational Oncology Research Center on projects intersecting coagulation disorders and cancer-related thrombosis, driving innovation in diagnostic protocols for complex clinical scenarios.