Charles Weitz

Charles Weitz, MD, PhD, is the Robert Henry Pfeiffer Professor of Neurobiology at Harvard University's Department of Neurobiology. His research focuses on understanding mammalian circadian clocks through molecular, biochemical, genetic, and structural approaches. The Weitz lab investigates circadian clock mechanisms using techniques like cryo-electron microscopy to study protein complexes.

Research Interests: Weitz's work centers on circadian rhythms, exploring how molecular oscillators regulate physiology and behavior. Key areas include the transcriptional feedback loop mechanism, circadian hepatocyte clocks, and the role of peripheral clocks in homeostasis. His lab also studies thyroid hormone structures and synaptic activity-DNA repair links via cryo-EM.

Publications Trends: Recent studies highlight structural biology applications (e.g., thyroglobulin cryo-EM structures), circadian clock synchronization in hepatocytes, and molecular mechanisms of feedback regulation. His work bridges basic clock biology with clinical implications in metabolism and neurobiology.

Lab & Resources: The Weitz lab is part of Harvard's neurobiology community, collaborating with centers like the Hock E. Tan and K. Lisa Yang Center for Autism Research. They utilize advanced imaging and molecular tools to dissect circadian machinery.