Charles Limoli

Charles Limoli is a Professor and Vice Chair of Research in the Department of Radiation Oncology at the University of California, Irvine (UCI) School of Medicine. His research focuses on understanding the biological effects of ionizing radiation, particularly on cellular and neurological systems. He investigates mechanisms underlying radiation-induced damage to stem cells, oxidative stress pathways, and the development of novel therapeutic strategies to mitigate radiation side effects. Dr. Limoli’s work includes studies on FLASH radiotherapy, a high-dose-rate treatment modality that may reduce damage to healthy tissues while maintaining tumor efficacy. His contributions span preclinical and translational research, with applications in cancer therapy and space radiation protection.

Research interests include radiation biology, neuroprotection, stem cell regeneration, and the development of imaging techniques to assess treatment outcomes. He leads studies on the effects of galactic cosmic radiation relevant to space exploration and has contributed to international collaborations advancing radiation therapy techniques. Grants and funding include support from NIH (e.g., R24 HD050837).