About
Bruno Calabretta is a Professor in the Department of Pharmacology, Physiology, & Cancer Biology and holds a concurrent professorship in Molecular Biology and Gene Regulation. His research addresses fundamental mechanisms in hematopoiesis and leukemia pathogenesis, with a focus on BCR/ABL oncogenic signaling, transcriptional regulation, and stem cell biology. Contact details: 233 South 10th Street, Philadelphia, PA 19107; Phone: 215-503-4522.
Research Expertise: Dr. Calabretta investigates perturbations in hematopoietic cell growth pathways leading to leukemic transformation. Key areas include:
- BCR/ABL-dependent suppression of apoptosis and autophagy
- Roles of transcription factors c-Myb and C/EBPalpha in normal/leukemic stem cells
- Signal transduction dysregulation in leukemogenesis
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