Bernhard Wünsch

Prof. Bernhard Wünsch is a Professor at the Institute of Pharmaceutical and Medicinal Chemistry at the University of Münster. His research focuses on developing novel ligands for sigma receptors and ion channels, with particular emphasis on creating PET tracers and fluorescent probes for neurological imaging. His work bridges medicinal chemistry and neuropharmacology to develop tools for studying brain disorders.

Research Focus: Three primary research streams include: 1) Design of sigma receptor ligands for PET imaging of neurological disorders, 2) Development of potassium channel modulators for cancer and pain research, and 3) Creation of fluorescent probes for ion channel visualization. His laboratory employs advanced synthetic chemistry techniques combined with pharmacological validation.

Methodological Approach: Publications demonstrate sophisticated organic synthesis of spirocyclic compounds and fluorinated molecules, rigorous receptor binding assays, and translational applications in oncology and neuroscience. Recent work emphasizes enantioselective synthesis and structure-activity relationship studies.

Collaborations: Partners with imaging specialists and neurobiologists to validate probes in disease models. Research has applications in Alzheimer's disease, cancer diagnostics, and neuropathic pain management.