Angela Mathison

Angela Mathison, PhD, is an Associate Professor in the Department of Surgery at the Medical College of Wisconsin, with secondary affiliation to the Mellowes Center for Genomic Sciences and Precision Medicine. She holds leadership roles as Director of 'Omics Research and Development and Associate Director for Operations and Academic Relationships. Her academic journey includes postgraduate training at Mayo Clinic and faculty promotion from Assistant to Associate Professor in 2025.

Dr. Mathison's research focuses on genomic mechanisms in disease pathogenesis, particularly in pancreatic cancer, epigenetics, and precision medicine. Her work integrates computational biology with experimental approaches to investigate chromatin remodeling, transcriptional regulation, and therapeutic targeting of oncogenic pathways. Key interests include KRAS-driven carcinogenesis, epigenetic modifiers like EZH2/EHMT2, and radiation response mechanisms.

Her recent publications demonstrate strong emphasis on translational bioinformatics, with consistent themes in: 1) Structural characterization of cancer-associated genomic variants, 2) Epigenetic regulation of tumor microenvironments, 3) Radiation-immune interactions in oncology, and 4) Computational drug repositioning strategies. The work frequently employs multi-omics integration across pancreatic, head/neck, and liver pathologies.

Awards include:

• Poster of Distinction, American Pancreatic Association (2014)
• Best Faculty Poster Award, CTSI SEAWINDS Symposium (2024)

She mentors numerous trainees and leads NIH-funded projects:

• Co-I on NIH R01: 'Targeting Epigenomic Regulators at the Replication Fork in PDAC' (2021-2026)
• PI on AHW grants: 'Epigenetic Alterations in Gender-Affirming Care' (2025) and 'Rare Disease Systems Biology' (2024)

Dr. Mathison directs the 'Omics Research Development Core and co-leads the Precision Medicine Education Program. She serves on multiple institutional committees including the Institutional Biosafety Committee and VBRI's Scientific Advisory Committee.