Andrew W. Duncan

Andrew W. Duncan, PhD is an Associate Professor of Pathology in the Division of Experimental Pathology at the University of Pittsburgh School of Medicine. He is a core faculty member in the McGowan Institute for Regenerative Medicine, a member of the University of Pittsburgh Cancer Institute, and holds a secondary appointment in the Department of Bioengineering.

Dr. Duncan's research focuses on liver development, homeostasis, and regeneration, with particular emphasis on hepatic polyploidy and aneuploidy. His lab investigates how polyploid hepatocytes undergo specialized cell divisions to form aneuploid daughter cells, generating genetic diversity within the liver. This research has revealed that aneuploid hepatocytes play specialized roles in liver regeneration, promoting adaptation and resistance to chronic liver injury. His work bridges fundamental cell biology with potential clinical applications in liver disease and cancer.

Recent publications demonstrate Dr. Duncan's active research program with significant contributions across multiple aspects of liver biology. His work spans from basic mechanisms of hepatocyte polyploidy to translational applications in liver disease and cancer, appearing in high-impact journals including Hepatology, Gastroenterology, and Nature.

• Core faculty member, McGowan Institute for Regenerative Medicine
• Member, University of Pittsburgh Cancer Institute
• Secondary appointment, Department of Bioengineering
• Member, Cellular and Molecular Pathology Graduate Training Program

Dr. Duncan maintains an active research program with NIH funding supporting multiple projects. His lab provides training opportunities for graduate students and postdoctoral fellows interested in liver biology, regeneration, and disease mechanisms. The lab collaborates extensively across disciplines to advance understanding of liver physiology and pathology.

The Duncan Lab is part of the McGowan Institute for Regenerative Medicine, providing access to state-of-the-art facilities and interdisciplinary research opportunities in regenerative medicine and tissue engineering.