Andrew Holle

Andrew Holle is an Assistant Professor at the Mechanobiology Institute, National University of Singapore, where he leads the Confinement Mechanobiology Lab within the Department of Biomedical Engineering. His work spans mechanobiology, stem cell differentiation, cancer mechanobiology, and microfluidics, with a focus on understanding how physical confinement influences cellular behavior.

Education:

• B.S.E. in Bioengineering (Minor in Statistics), Arizona State University (2008)
• Ph.D. in Bioengineering, University of California San Diego (2013)

Research in the Confinement Mechanobiology Lab centers on the hypothesis that stem cell differentiation is driven by mechanical cues during migration through confined extracellular matrix (ECM) environments. The lab develops microfluidic systems to mimic ECM confinement and studies its impact on osteogenic differentiation, cancer cell migration, and cellular condensates.

Recent publications highlight interdisciplinary approaches combining mechanobiology, nanotechnology, and microfluidics to explore nuclear morphological changes, volume regulation, and ligand signaling in confined cellular environments.

Laboratory Members:

• Privita Edwina (Research Fellow)
• Vaishnavi Rangaraj (Research Assistant)
• Sriram Muthukumar (Research Fellow)
• Chang Ye Ji (PhD Student)
• Gao Xu (PhD Student)
• Lim Yuan Bin (PhD Student)
• Shinny Sunny (PhD Student)
• Lee Jia Wen Nicole (PhD Student)
• Li Yixuan (PhD Student)