Ali Mortazavi

Ali Mortazavi is a Professor at the University of California, Irvine, specializing in genomics, computational biology, and transcriptional regulation during development. His research focuses on comparative analysis of gene regulatory networks in human and mouse models, particularly in hematopoietic, skeletal muscle, and embryonic stem cells, using advanced sequencing technologies like ChIP-seq, ATAC-seq, and single-cell RNA-seq.

• Key research areas: transcriptional regulation, gene network conservation, and developmental genomics
• Active ENCODE Consortium member since 2008
• Primary model systems: human/mouse mammalian cells and Steinernema nematodes

Recent publications highlight his work on T-cell fate determination, nematode parasitism mechanisms, myeloid differentiation networks, and single-cell resolution of gene expression dynamics, demonstrating expertise in integrating functional sequencing assays with computational modeling.