Alex Clarke

Associate Professor Alex Clarke is a Wellcome Trust-funded researcher and Honorary Consultant Rheumatologist at the Nuffield Orthopaedic Centre, affiliated with the University of Oxford. He leads the Clarke Group at the Kennedy Institute of Rheumatology, focusing on the intersection of metabolism and immunity.

• PhD in Medicine (2013), King’s College London
• MBBS in Medicine (2001), University College London (UCL)

Dr. Clarke's research explores how metabolic pathways regulate immune cell function and disease progression. His work spans autophagy mechanisms, mitochondrial dynamics in B cells, and metabolic dysregulation in autoimmune disorders like lupus. Recent studies investigate germinal center B cell metabolism and glycogen synthase kinase-3's role in Treg development.

His recent publications (2025-2024) highlight trends in immunometabolism, autophagy, and genetic testing applications. Awards include prestigious Wellcome Trust Clinical Research fellowships.

• Wellcome Trust Clinical Research Training Fellowship (2013)
• Wellcome Trust Clinical Research Career Development Fellowship (2018)

Dr. Clarke's lab investigates metabolic regulation in immune cell differentiation and autoimmune disease pathogenesis.