Alessandro Tossi

Alessandro Tossi is a Full Professor in the Department of Life Sciences at the University of Trieste, Italy. He actively participates in doctoral programs, including the Molecular Biomedicine and Functional Genomics cycles, and contributes to departmental governance as a member of the Department's Board. His research focuses on host defense peptides (HDPs/AMPs), investigating their non-lytic mechanisms of action and biomedical applications against multidrug-resistant pathogens.

Research Interests include:

• Molecular mechanisms of antimicrobial peptides
• Optimization of proline-rich AMPs (PR-AMPs)
• Ribosomal targeting in Gram-negative bacteria
• Anti-biofilm strategies for clinical infections
• Peptide lipidation for enhanced efficacy

Publications highlight his work on:

• Characterization of Bac5/Bac7 fragments
• Development of all-D peptide derivatives like D-BMAP18
• Sub-inhibitory effects on bacterial motility
• Structure-activity relationships in AMPs

Current Projects involve collaborations with institutions such as:

• IRCCS Centro di Riferimento Oncologico di Aviano
• ICGEB-International Centre for Genetic Engineering and Biotechnology
• Azienda Sanitaria Universitaria Giuliana Isontina (ASUGI)