Adam R. Wolfe

Adam R. Wolfe, MD, PhD, is an Assistant Professor in the Department of Radiation Oncology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. As a physician-scientist, he treats gastrointestinal cancers at the UAMS Radiation Oncology Center while leading translational research at the Winthrop P. Rockefeller Cancer Institute focused on overcoming radiation resistance in pancreatic cancer.

• Education: Dual MD/PhD from UT McGovern Medical School & MD Anderson (2016); BS in Biological Sciences from Texas Tech University (2009)

Research Focus:
Dr. Wolfe's work bridges DNA repair mechanisms and radiation therapy efficacy. His lab investigates:

• Molecular drivers of radiation resistance in KRAS-mutant pancreatic cancer
• Role of DNA repair proteins in therapeutic outcomes
• Development of novel radiosensitizers via preclinical models
• Translational application of DNA damage biomarkers
• Methionine restriction as a dietary radiosensitization strategy
• Epigenetic regulation via SETD2 and histone modifications

Scientific Contributions:
Recent publications highlight his team's work on:

• Methionine metabolism in KRAS-mutant rectal cancer
• CDK1 inhibition to enhance pancreatic cancer radiosensitivity
• Grid radiotherapy for bulky tumors
• RAS-RAF-miR-296-3p pathway in DNA repair signaling

Awards & Funding:
Recipient of:

• $583,200 ACS Grant (2023)
• KL2 Mentored Research Career Award (2022)
• Winthrop P. Rockefeller Team Science Award (2022)

Academic Leadership:
Mentors postdoctoral fellows and PhD candidates while operating the Wolfe Lab, which utilizes:

• Genetic & proteomic approaches
• Small Animal Radiation Research Platform
• High-field MRI for translational studies
• Quantitative immunohistochemistry