جست‌وجوی استاد و پژوهشگر

Pillai Ramesh Shanmughomمشاهده پروفایل

استاد

• Epigenetics
• RNA modifications
• miRNAs
• +۵ مورد دیگر

Ramesh Shanmughom Pillai is a Full Professor at the Department of Molecular Biology, University of Geneva, Switzerland. He holds additional roles as a Visiting Professor at the University of Kumamoto, Japan, and has been a Group Leader at EMBL Grenoble and a postdoctoral fellow at the Friedrich Miescher Institute. His research focuses on RNA modifications, epigenetics, and piRNA pathways in germline biology. Pillai has received prestigious awards including the ERC Consolidator Grant and The RNA Society Scaringe Award. Education: BSc Botany (University of Kerala, India) MSc Biotechnology (IIT Roorkee, India) PhD in Cell Biology (University of Bern, Switzerland) Research Interests: Pillai’s work centers on RNA biology, particularly the role of RNA modifications (e.g., m6A, m6Am) in development and fertility. He investigates piRNA biogenesis, transposon silencing, and the molecular mechanisms of RNA-protein interactions. His studies bridge biochemistry, genetics, and structural biology to elucidate how RNA molecules regulate critical biological processes. Teaching & Service: At the University of Geneva, he teaches Molecular Biology courses (BSc/MSc levels) and advises 5 PhD students and 4 postdocs. He chairs the ERC Consolidator Grant Review Panel and organizes major conferences like the PIWI/piRNAs Meeting and Swiss RNA Workshop. Pillai also serves on editorial boards for Nucleic Acids Research and RNA . Awards: ERC Consolidator Grant (2015) Best PhD Thesis Award (2003) RNA Society Scaringe Award (2005) Grants & Labs: Funded by ERC Starting and Consolidator Grants, his lab explores RNA modification networks in germ cells. Former trainees include Professors Simon Conn (Flinders University) and Hao Wu (CAS, China).

• Computational Genomics
• Gene Regulation
• RNA Biology
• +۴ مورد دیگر

Susanne Bornelöv is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on computational genomics and gene regulation, particularly exploring posttranscriptional mechanisms such as codon optimality-mediated mRNA decay and transposon silencing. She uses computational methods, ribosome profiling, and Drosophila models to study how codon usage, tRNA availability, and RNA modifications influence gene regulation and genome evolution. Her work integrates artificial intelligence (AI) and comparative genomics to model gene regulatory processes and design novel regulatory elements. Key research areas include piRNA clusters' roles in suppressing retroviruses, codon usage bias in pluripotent stem cells, and the interplay between mRNA methylation and protein synthesis. The Bornelöv Group collaborates widely, including with institutions like Cold Spring Harbor Laboratory, to advance understanding of fundamental gene expression principles. Publications highlight contributions to topics like deep learning in genomics, evolutionary conserved piRNA mechanisms, and transcriptional regulation. She leads a group open to interns, students, and researchers, fostering interdisciplinary approaches to address complex biological questions.

Ronald van Rijمشاهده پروفایل

استاد

• Antiviral research
• piRNA pathway
• Insect viruses
• +۷ مورد دیگر

Professor Ronald van Rij holds the position of Professor of Experimental Virology and Head of the Laboratory of Experimental Virology at Radboud University Medical Center in Nijmegen, Netherlands. He also serves as a Guest Professor at the University of Pavia, Italy. His research focuses on antiviral mechanisms in insects, particularly the roles of RNA interference (RNAi) and piRNA pathways in Drosophila melanogaster and Aedes aegypti mosquitoes. He has pioneered studies on viral defense in insects and vector competence, with translational work on antiviral compounds against pathogens like Zika and SARS-CoV-2 through the international 'COVID Moonshot' project. Education includes a PhD from the University of Amsterdam (2002) and postdoctoral fellowships at UCSF (USA) and the Hubrecht Institute (Netherlands). He has received prestigious grants such as ERC Consolidator and VICI awards, and was honored as Lecturer of the Year (2019) and PhD Supervisor of the Year (2017). Awards: ERC Proof of Concept Grant (2020), NWO VICI (2017), ERC Consolidator (2014), NWO VIDI (2008), EMBO Fellowship (2002). Teaching: Coordinates courses on virology, non-coding RNA, and innate immunity at Radboud University. Labs: Manages a BSL-3 facility for studying vector-borne pathogens in mosquitoes. His work bridges basic science and translational medicine, with emphasis on small RNA pathways and arbovirus control.

Dinshaw Patelمشاهده پروفایل

استاد

• Structural Biology
• Biochemistry
• CRISPR-Cas Systems
• +۷ مورد دیگر

Dinshaw Patel is a Professor at the Structural Biology Program of Memorial Sloan Kettering Cancer Center (MSKCC), holding the Abby Rockefeller Mauzé Chair in Experimental Therapeutics. He has affiliations with Columbia University, The Rockefeller University, and Weill Cornell Medicine through collaborative research projects. PhD in Photochemistry, New York University Postdoctoral training in Biochemistry and Biophysics 17 years at AT&T Bell Laboratories Professor at Columbia University-Health Sciences His research focuses on structural biology of macromolecular recognition systems, particularly CRISPR-Cas surveillance complexes, cGAS-STING pathways, Structure Maintenance of Chromosomes (Smc5/6, MRX) complexes, and epigenetic regulation via histone/DNA modifications. His work spans RNA-mediated processes (siRNA/piRNA pathways), molecular chaperones, and riboswitches/ribozymes. Recent projects include structural characterization of bacterial antiphage defense systems (Lamassu, Kiwa), small molecule inhibitors targeting SARS-CoV-2 RNA capping machinery, and complexes involved in leukemias/lymphomas. Publications highlight structural elucidation of CRISPR-Cas systems using cryo-EM and x-ray crystallography, DNA repair mechanisms, and RNA-protein interaction dynamics. Key collaborations include Luciano Marraffini (Rockefeller), Xiaolan Zhao (MSKCC), and Thomas Tuschl (Rockefeller). National Academy of Sciences member AAAS member AT&T Bell Labs Distinguished Technical Staff Award New York University Distinguished Alumnus Award FEZANA Excellence in Profession Award Lifetime Achievement, American Association of Indian Scientists in Cancer Research Students and trainees benefit from his expertise in structural biology techniques (NMR, crystallography, cryo-EM), biochemical assays, and biophysical approaches. His lab participates in the Tri-Institutional PhD Program in Chemical Biology and maintains affiliations with multiple institutions including Beijing Advanced Innovation Center for Structural Biology and ETH Zürich.

Jinchuan Xingمشاهده پروفایل

استاد

• Mobile Elements
• Human Genomic Variation
• Evolutionary Genetics
• +۱۴ مورد دیگر

Jinchuan Xing is a Professor at Rutgers, The State University of New Jersey, where he leads the Xing Lab of Genomics. His research focuses on human genomic variation, mobile DNA elements, evolutionary and population genetics, and their implications for human disease. He integrates computational and experimental methods to study genome-wide variation, with applications in disease gene identification and genomic technology development. His research interests include: Mobile DNA element biology Human demographic history and population diversity Disease gene identification using whole-exome and whole-genome sequencing High-altitude adaptation genetics Transposable element regulation and expression piRNA and small RNA pathways His recent publications highlight a strong trend in reproductive genomics, particularly in identifying genetic risk factors for embryo aneuploidy in IVF patients, using advanced sequencing technologies. Other work spans evolutionary genomics in diverse species (bats, moths, Drosophila), structural variation in neurodevelopmental disorders, and proteogenomic discovery. His lab actively develops and applies bioinformatic tools for variant analysis and gene prioritization. Scientific awards and honors are not explicitly mentioned in the provided text. Jinchuan Xing advises several graduate students, including Nan Wang, Siqi, Ellie Lu, and Tongji Xing. His lab has received significant funding, including an R01 grant from NICHD on aneuploidy risk, a grant from the Center for Human Evolutionary Studies, and a Life Sciences Alliance Pilot Seed Funding grant in collaboration with the Department of Statistics. These grants support research in fertility genomics, disease gene discovery, and genomic tool development. The Xing Lab of Genomics is an active research group conducting interdisciplinary studies combining genomics, bioinformatics, and molecular biology. The lab welcomes new members regularly, including master’s and PhD students, and collaborates across departments. Current projects include understanding the genetic basis of meiosis, fertility, and high-altitude adaptation, as well as developing Markovian gene networks for disease gene discovery.

Jean (Jiayu) Wenمشاهده پروفایل

دانشیار

• RNA Biology
• Computational Biology
• MicroRNA Regulation
• +۵ مورد دیگر

Associate Professor Jean (Jiayu) Wen holds positions at The Australian National University (ANU), including Group Leader of The Wen Group, ARC Future Fellow, and Deputy Director of The Shine-Dalgarno Centre for RNA Innovation. She specializes in computational and molecular biology, focusing on RNA regulation, gene expression, and cancer genomics. Her affiliations include ANU’s Division of Genome Sciences and Cancer, and the Centre for Computational Biomedical Sciences. Education: BEng in Electronic Engineering (Beijing), MSc in Computer Science (Lakehead University), PhD in Computational Biology (ANU). Postdoctoral training at Copenhagen University and Memorial Sloan-Kettering Cancer Center. Research interests span RNA structures, microRNA biogenesis, transcriptome dynamics, and epigenetic regulation. Her work addresses intragenomic conflicts, cancer mechanisms, and neural development. Notable projects include RNA-based machine learning models for RNA-RNA interactions and immune cell differentiation studies. Publications highlight contributions to RNA interference pathways, tumor development, and Drosophila genetics. Awards include the ARC Future Fellowship. She leads interdisciplinary teams advancing computational and experimental approaches in genomics and systems biology.

Phillip D. Zamoreمشاهده پروفایل

استاد

• RNA Interference
• Small RNA Biology
• piRNA Pathways
• +۳ مورد دیگر

Phillip D. Zamore serves as Chair and Professor of the RNA Therapeutics Institute at the University of Massachusetts Chan Medical School School of Medicine and is an Investigator of the Howard Hughes Medical Institute. He holds the Gretchen Stone Cook Professorship in Biomedical Sciences and leads pioneering research in RNA biology. Dr. Zamore earned his A.B. (1986) and Ph.D. (1992) in Biochemistry and Molecular Biology from Harvard University, followed by postdoctoral training at The Whitehead Institute for Biomedical Research. His research focuses on small RNA silencing pathways including RNA interference (RNAi), microRNA, and PIWI-interacting RNA (piRNA) mechanisms across eukaryotic and prokaryotic systems. Key investigations explore how Argonaute proteins achieve sequence-specific regulation of transcription and translation, with emphasis on piRNA biogenesis in germ cells and bacterial Argonaute functions. Analysis of his recent publications reveals dominant themes in transposon silencing, piRNA pathway evolution, RNA therapeutic development, and molecular mechanisms of gene regulation. His work bridges fundamental biochemistry with clinical applications, particularly in RNA-based therapies for genetic disorders. Notable scientific honors include: Chancellor’s Medal for Excellence in Scholarship (2015) Dean's Award for Research Mentoring (2011) Fellow of the National Academy of Inventors (2014) Election to the American Academy of Arts & Sciences, National Academy of Sciences, and National Academy of Medicine (2023) Dr. Zamore has co-founded multiple biotechnology companies including Alnylam Pharmaceuticals (2002), which developed the FDA-approved RNAi therapeutic ONPATTRO for hereditary transthyretin-mediated amyloidosis, and Voyager Therapeutics (2014). His laboratory has trained dozens of researchers now leading institutions worldwide, with over 150 publications and 119 patents reflecting his translational impact. Current research leverages biochemical and genetic approaches to develop RNA-guided therapies for diseases like Huntington's. The Zamore Laboratory operates within the RNA Therapeutics Institute at UMass Chan Medical School, utilizing advanced genomic, biochemical, and imaging technologies to study small RNA pathways in model organisms including Drosophila, mice, and bacterial systems.

Robert Reenanمشاهده پروفایل

استاد

• Aging
• ALS
• Alzheimer's Disease
• +۱۰ مورد دیگر

Dr. Robert Reenan is a Professor of Biology at Brown University, affiliated with the Department of Molecular Biology, Cell Biology, and Biochemistry. His research spans evolutionary genetics, RNA editing, and neurogenetics, focusing on how genomes regulate rapid signaling in the brain through mechanisms like RNA editing and comparative genomics. He has contributed extensively to understanding RNA editing’s role in diseases such as ALS, Alzheimer’s, and epilepsy. Education: PhD in Genetics (Harvard Medical School, 1991), AB in Biology (University of Missouri, 1984) Research Interests: Dr. Reenan investigates RNA editing, ion channels, neurogenetics, and their implications in aging, neurological disorders, and evolutionary adaptation. His work reveals how RNA editing modulates gene function in Drosophila, impacting diseases like ALS and epilepsy. Grants & Collaborations: He has secured major grants from the ALS Association, NIH (NINDS), Ellison Medical Foundation, and NSF. Collaborations include partnerships with researchers like Stephen Helfand, Gary Wessel, and Louis Lapierre. Teaching: Dr. Reenan teaches courses in genetics, molecular genetics, neurogenetics, and scientific communication.

Sebastian Falkمشاهده پروفایل

دانشیار

• RNA Processing
• RNA Surveillance
• Small Non-coding RNA Biology
• +۳ مورد دیگر

Sebastian Falk is an Associate Professor at the Max Perutz Labs, part of the University of Vienna, within the Department of Structural and Computational Biology. His research focuses on the biogenesis and action of small RNAs, particularly piRNAs, employing structural biology and biochemical approaches to elucidate molecular mechanisms. He received the prestigious EMBO Young Investigator award in 2022. His lab investigates RNA surveillance pathways, mRNA splicing, and the interplay between RNA processing and degradation. Key projects include studying the MTR4-NRDE2-CCDC174 complex and piRNA processing factors in C. elegans. Falk has organized major symposia on RNA biology and contributed to high-impact publications in journals like Nature and Nucleic Acids Research . EMBO Young Investigator (2022) Grants: 'Characterization of piRNA processing factors in C. elegans' (2023-2026)

Kristian Almstrupمشاهده پروفایل

دانشیار

• Genetics
• Epigenetics
• Reproduction
• +۹ مورد دیگر

Kristian Almstrup serves as Associate Professor at the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and holds a Senior Scientist position at the Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet. His dual appointment bridges clinical practice and academic research in reproductive genetics. Dr. Almstrup's research primarily focuses on the intersection of genetic and epigenetic variation with reproductive endpoints, testicular gene expression, and sperm cell function. His work has pioneered understanding of piRNAs in human spermatogenesis, genetic variants causing non-obstructive azoospermia, and genetic factors associated with testicular germ cell cancer. His group employs cutting-edge techniques including single-cell/nuclei methods and spatial transcriptomics to study the complex cellular composition of testicular tissue. Analysis of Almstrup's 15 most recent publications reveals a consistent focus on male reproductive genetics, with particular emphasis on non-coding RNAs (especially piRNAs), genetic determinants of spermatogenic failure, and environmental factors in declining fertility. His research spans from basic molecular mechanisms to clinical applications, with several publications in high-impact journals including Nature, Nature Communications, and the New England Journal of Medicine. Dr. Almstrup actively contributes to medical education through teaching in the Medical Genetics course for Medicine and Molecular Biomedicine students, as well as organizing PhD courses in Genetics of Reproduction. His editorial work includes serving as Editor for Andrology, Scientific Reports, and Frontiers in Cell and Developmental Biology. The Almstrup Group, based at Rigshospitalet, maintains an active research program with current team members including Nina Mørup Nygaard, Sofia B. Winge, Gülizar Saritas, Ailsa Maria Main, and Maria Lykkegaard Nicolaisen. The group participates in several international consortia including GEMINI, IMiGC, and TECAC, focusing on male infertility and testicular cancer genetics.

Marjo den Broederمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Zebrafish Models
• Epigenetics
• +۷ مورد دیگر

Marjo den Broeder is a Researcher and Teacher in the Department of Biology at Utrecht University, Faculty of Science, specializing in Developmental Biology. She serves as the head of the Aquatic Facility, where she supports zebrafish-based research in toxicology, fundamental biology, and biomedical studies through expert guidance in experimental design and animal care. University: Utrecht University School: Faculty of Science Department: Department of Biology Position: Researcher and Teacher Role: Head of Aquatic Facility Her research focuses on developmental processes in zebrafish, particularly adipogenesis, lipid metabolism, epigenetic regulation, and the effects of environmental chemicals. She employs advanced techniques such as stimulated Raman scattering microscopy and collaborates widely on topics including obesity, circadian biology, and reproductive development. The recent publications highlight a strong trend in using zebrafish as a model organism to study metabolic diseases, epigenetic mechanisms, and environmental toxicology. Her work spans molecular embryology, signal transduction (e.g., Hedgehog pathway), and innovative imaging technologies. Interdisciplinary themes include photodynamic therapy for cancer and hormonal regulation of spermatogenesis. Marjo den Broeder has not been publicly recognized with scientific awards in the provided text. She actively contributes to research and mentoring within the Biology department, particularly through her leadership in the Aquatic Facility. While no formal grants are mentioned, her consistent publication record suggests active participation in funded research projects. Her collaborations with prominent scientists like Juliette Legler and Leonie Kamminga underscore her integration into the research community. As head of the Aquatic Facility, she leads a critical infrastructure unit that provides zebrafish husbandry and technical support to researchers across disciplines, ensuring high-quality standards in animal care and experimental methodology.

Gregory J. Hannonمشاهده پروفایل

استاد

• Small RNA Biology
• RNA Interference
• Cancer Biology
• +۷ مورد دیگر

Gregory J. Hannon is a distinguished Professor at Cold Spring Harbor Laboratory (CSHL) and an Investigator of the Howard Hughes Medical Institute, renowned as one of the world's foremost authorities on small RNA biology and RNA interference. His research has significantly advanced our understanding of gene regulation mechanisms with profound implications for cancer treatment and genome stability. Hannon's educational background includes training that led to his current position as a leading molecular biologist. His research focuses on the biological roles of small RNAs and the mechanisms by which they operate, with particular emphasis on germ cells (which have the most elaborate set of small RNA pathways) and cancer biology (especially breast and pancreatic cancer). His laboratory's groundbreaking work has identified and characterized major biogenesis and effector complexes for small interfering RNAs and microRNAs, including Dicer, RISC, and elements of the Microprocessor. More recently, his team has made significant discoveries regarding piwi-interacting RNAs (piRNAs) and their role in defending the genome from mobile genetic elements. Among his most significant publications are studies on the structure of human Argonaute protein, mechanisms of transposon defense in germ cells, and how breast tissue 'remembers' a first pregnancy through epigenetic changes. His research has consistently appeared in top-tier journals, with several publications recognized by Science as 'Breakthrough of the Year.' Elected to National Academy of Sciences (2012) NIH MERIT Award from National Institute of General Medical Sciences (2013) National Academy of Sciences Award in Molecular Biology (2007) Geoffrey Marshall Mentoring Award from Northeastern Association of Graduate Schools (2011) Howard Hughes Medical Institute Investigator Hannon has mentored 12 postdoctoral fellows and 17 graduate students, with exceptional outcomes including multiple prestigious awards for his trainees. Over 60% of his 200+ publications include graduate student co-authorship. His laboratory has developed innovative technologies including RNAi libraries targeting entire genomes and methods used in Neanderthal genome sequencing. He also serves as director of the Cancer Research UK Cambridge Institute, demonstrating his international leadership in cancer research.

• Cell Biology
• Molecular Biology
• Embryology
• +۹ مورد دیگر

Masaki Shirayama is an Assistant Professor at the UMass Chan Medical School , affiliated with the RNA Therapeutics Institute under the T.H. Chan School of Medicine . His research focuses on Cell Biology , Molecular Biology , and Developmental Biology , with a specialization in C. elegans genetics and RNA regulatory mechanisms. Education : PhD in Biology from the University of Tokyo , Japan. Shirayama's work explores the roles of Argonaute proteins , piRNAs , and epigenetic signals in germline gene expression and RNA interference . He investigates asymmetric cell division , chromosome segregation , and Wnt signaling pathways using Caenorhabditis elegans as a model organism. His publications (15 most recent) highlight themes in RNA regulation , epigenetic inheritance , germline genome surveillance , and developmental gene networks . Key subfields include piRNA function , Argonaute pathways , cytokinesis , cell polarity , and RNA-binding protein interactions . Shirayama collaborates with researchers such as Craig Mello , Darryl Conte , and Zhiping Weng within the RNA Therapeutics Institute. His work spans genetics , embryology , and molecular mechanisms of gene regulation.

Russell Finleyمشاهده پروفایل

استاد

• Regulatory networks
• Cell cycle regulation
• Drosophila development
• +۳ مورد دیگر

Russell Finley is a Professor at Wayne State University, with joint appointments in the Departments of Molecular Medicine and Genetics and Biochemistry, Microbiology, and Immunology. He serves as Division Director for Education and Graduate Officer in CMMG and is a member of the Karmanos Cancer Institute. His research focuses on regulatory networks controlling cell proliferation, using high-throughput technologies like yeast two-hybrid systems and RNAi screens. PhD in Molecular Biology from SUNY Upstate Medical University (1990) Postdoctoral training at Harvard Medical School and Massachusetts General Hospital (1990-1995) Research keywords include protein interaction networks, Drosophila development, cancer biology, and systems biology. His 2024-2010 publications highlight work on cell cycle regulators, pathogen interactions, and bioinformatics methodologies. He teaches advanced courses in cancer biology, molecular genetics, and systems biology.

• Genetics
• Epigenetics
• Germline Development
• +۷ مورد دیگر

Valerie Reinke is the Harvey and Kate Cushing Professor of Genetics and Chair of the Department of Genetics at Yale School of Medicine. A leading expert in Caenorhabditis elegans germline gene regulation, her work explores epigenetic mechanisms, piRNA biogenesis, and tissue-specific transcriptional networks using cutting-edge genomic and molecular approaches. B.S. in Genetics (University of Illinois, 1990) Ph.D. in Biomedical Sciences (University of Texas Health Sciences Center, 1996) Postdoctoral work on C. elegans genomics at Stanford University (1996-2000) Her research addresses fundamental questions about genome organization, chromatin dynamics, and trans-generational epigenetic inheritance. Key projects include: Mechanisms of temporally regulated piRNA clusters Chromatin-based regulation of germline-to-embryo transitions Evolutionary conservation of histone modification patterns Her lab's work has broad implications for human health, spanning cancer biology, neurodegenerative diseases, and male infertility. Collaborations include researchers from the Center for RNA Science and Medicine, Yale Stem Cell Center, and international institutions.