جستجوی استاد راهنمای دانشگاهی

Harris H. Wang is an Associate Professor in the Department of Systems Biology and Department of Pathology and Cell Biology at Columbia University's Vagelos College of Physicians and Surgeons, where he also serves as Interim Chair of Systems Biology. He is affiliated with the Center for Computational Biology and Bioinformatics (C2B2) and the Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS). B.S., Physics and Mathematics, MIT Ph.D., Biophysics, Harvard University Dr. Wang's research lies at the intersection of systems and synthetic biology, focusing on developing foundational technologies for genome engineering, microbiome manipulation, and synthetic genomics. His lab pioneers methods such as MAGE, MAGIC, CAST, and CAMII to enable high-throughput genetic manipulation, in situ microbiome engineering, and AI-driven microbial culturomics. Key research themes include understanding microbial community dynamics, engineering cellular memory systems, designing biocontained genetic circuits, and applying synthetic biology to human health challenges in personalized medicine and infectious disease. His recent publications reveal a strong trend in spatial and functional metagenomics, CRISPR-based microbiome editing, and synthetic biology tools for data storage and genetic stability. The articles span high-impact journals like Nature , Science , and Nature Biotechnology , reflecting his leadership in developing scalable, programmable biological systems. Scientific Awards: NIH Director’s Early Independence Award Forbes 30 Under 30 in Science Sloan Research Fellowship NSF CAREER Award ONR Young Investigator Award Burroughs Wellcome Fund PATH Award Schaefer Scholar Blavatnik National Award Vilcek Prize PECASE Dr. Wang has advised numerous PhD and postdoctoral researchers, many of whom have gone on to independent scientific careers. His lab is supported by major grants from NIH, NSF, DARPA, DOE, and foundations including the Bill & Melinda Gates Foundation and CZ Biohub NY. He is actively involved in educational initiatives, including organizing Columbia’s iGEM team and the Cold Spring Harbor Laboratory Synthetic Biology course. The Wang Lab is based at the Columbia University Irving Medical Center and is part of national consortia such as the Engineering Biology Research Consortium (EBRC) and the Genome Project-Write (GP-Write) initiative. The lab develops and applies cutting-edge technologies in automation, machine learning, and synthetic biology to engineer microbiomes for applications in medicine, global health, and climate change.

• Systems Biology
• Synthetic Biology
• Genome Engineering
• +۱۷ مورد دیگر

Marc V Fuccillo is an Associate Professor of Neuroscience at the Perelman School of Medicine, University of Pennsylvania, where he leads a research laboratory focused on understanding the neural circuit mechanisms underlying behavioral control. His work bridges molecular, synaptic, and behavioral approaches to investigate how striatal circuits regulate mouse behavior from simple motor patterns to complex goal-directed actions. Fuccillo holds dual appointments in the Neuroscience and Cell and Molecular Biology Graduate Groups at Penn and maintains an active laboratory investigating the synaptic and circuit basis of neuropsychiatric disorders. Education: B.A. in Molecular and Cellular Biology and Music Performance (Violin) from Brown University (1998) Ph.D. in Developmental Genetics from New York University School of Medicine (2007) M.D. from New York University School of Medicine (2008) Fuccillo's research centers on the synaptic and circuit mechanisms of behavioral control, with particular emphasis on striatal circuits. His laboratory employs a range of technologies including mouse genetics, in vitro electrophysiology, in vivo imaging, and quantitative behavioral analysis to explore how neural circuits of the striatum regulate behavior and how disruptions in these circuits contribute to neuropsychiatric disorders. His work has particularly focused on autism-associated abnormalities in behavioral control, examining how synaptic adhesion molecules like neuroligins and neurexins shape circuit function and behavior, with significant findings regarding D1 dopamine receptor positive medium spiny neurons in the nucleus accumbens. Analysis of Fuccillo's recent publications reveals a strong focus on striatal circuit function across multiple dimensions. His work spans molecular neuroscience (examining synaptic adhesion molecules), cellular physiology (studying specific neuron types in striatal circuits), systems neuroscience (mapping circuit connectivity), and behavioral neuroscience (quantifying motor learning and decision-making). A unifying theme is how disruptions in specific molecular pathways lead to circuit-level abnormalities that manifest as behavioral phenotypes relevant to neuropsychiatric disorders, with particular attention to autism, OCD, and schizophrenia models. Scientific Recognition: Publications in high-impact journals including Nature Neuroscience, Current Biology, Cell Reports, and Neuron Research supported by multiple NIH grants including NIMH F32, NIMH K01, and HHMI Gilliam Fellowship awards for lab members Fuccillo actively mentors a diverse group of trainees including postdoctoral fellows, graduate students, and undergraduates. His laboratory has produced numerous successful alumni who have gone on to faculty positions, medical residencies, and graduate programs at prestigious institutions. His mentoring approach emphasizes technical skill development across multiple neuroscience disciplines while fostering independent scientific thinking. Current research in his lab is supported by NIH funding focused on understanding the molecular architecture of striatal circuits and their role in behavioral control, with three major research directions exploring molecular logic of striatal circuits, circuit mechanisms of behavioral control, and striatal dysfunction in neuropsychiatric disease models. The Fuccillo Laboratory operates within the Department of Neuroscience at the University of Pennsylvania, with access to state-of-the-art facilities for molecular, electrophysiological, imaging, and behavioral neuroscience research. The lab maintains active collaborations with other neuroscience research groups at Penn and beyond, creating a rich intellectual environment for studying the neural basis of behavior. Current research directions include investigating whether there is a molecular logic to striatal circuit composition, how striatal circuits shape behavioral control, and what mouse models of autism, schizophrenia, and OCD can reveal about striatal circuit dysfunction in disease pathophysiology.

• Synaptic transmission
• striatal circuits
• inhibition
• +۹ مورد دیگر

Michael U. Gutmann is a Senior Lecturer in Machine Learning at the School of Informatics, University of Edinburgh, and a member of the Institute for Adaptive and Neural Computation. His research lies at the intersection of machine learning, statistics, and scientific applications, with a focus on developing inference methods for complex and implicit models. Education: PhD in Computational Neuroscience, University of Tokyo MSc in Engineering and Applied Mathematics, Swiss Federal Institute of Technology (ETH) Zurich MSc, Ecole Centrale Paris His primary research interests include Bayesian inference, likelihood-free inference, optimal experimental design, unsupervised learning, and applications in computational biology and neuroscience. He is best known for introducing Noise-Contrastive Estimation (NCE), a foundational technique for training unnormalized statistical models. His recent work spans variational inference, density ratio estimation, flow models for missing data, and AI-driven experimental design in behavioral and biological sciences. His publications, including in NeurIPS , ICML , JMLR , and eLife , demonstrate a strong emphasis on methodological innovation for scientific discovery. He has contributed to open-source tools such as ELFI (Engine for Likelihood-Free Inference) and developed practical implementations of robust inference algorithms. Scientific Awards: No specific awards listed in the provided texts. Michael Gutmann actively supervises students and collaborates with leading researchers in machine learning and computational biology. He has secured research funding from EPSRC and BBSRC for projects in generative modeling and infectious disease epidemiology. He teaches advanced courses such as Probabilistic Modelling and Reasoning and Data Mining, reflecting his deep engagement with both theoretical and applied aspects of machine learning. Labs and Research Groups: Institute for Adaptive and Neural Computation (ANC), University of Edinburgh Former affiliations with Department of Mathematics and Statistics and Department of Computer Science at the University of Helsinki and Aalto University

• Machine Learning
• Bayesian Inference
• Likelihood-Free Inference
• +۹ مورد دیگر

C. Perry Chou is a full professor in the Chemical Engineering Department at the University of Waterloo, with a cross-appointment in Biology. He holds a BSc and MSc from National Taiwan University and a PhD from Rice University, all in Chemical Engineering. His research focuses on integrating biochemical, genetic, and metabolic engineering strategies to enhance biomanufacturing using microbial cell factories. Key areas include recombinant protein production, microbial biotechnology, and biofuel development. Education: PhD in Chemical Engineering, Rice University (1995) MSc in Chemical Engineering, National Taiwan University (1987) BSc in Chemical Engineering, National Taiwan University (1984) Research Interests: Dr. Chou’s work spans biochemical engineering, bioprocessing, and metabolic engineering. He develops strategies for microbial strain construction, fermentation optimization, and bioproduct purification. His research bridges fundamental biological sciences with applied engineering to advance biomanufacturing. Publications: His 90+ peer-reviewed articles highlight contributions to strain engineering, CRISPR-Cas9 tools, and microbial production of chemicals like 5-aminolevulinic acid and propionate. Recent trends emphasize nanomaterial applications (e.g., graphene oxide) and sustainable biofuel pathways. Awards: Canada Research Chair (Canada) 1000-talent Award (China) Advising & Grants: Dr. Chou actively mentors graduate students and contributes to editorial roles at journals like Biotechnology Advances and Scientific Reports . He teaches courses such as CHE 161 (Engineering Biology) and CHE 562 (Advanced Bioprocess Engineering). Labs/Teams: Collaborates with interdisciplinary teams to advance bioprocess development, though specific lab names are not explicitly mentioned in the text.

• biochemical engineering
• bioprocessing
• biomanufacturing
• +۷ مورد دیگر

Jonathan Conway is an Assistant Professor in the Department of Chemical and Biological Engineering at Princeton University and an associated faculty member of the High Meadows Environmental Institute (HMEI). He leads the Conway Lab, which focuses on engineering plant-microbe interactions for applications in bioagriculture, bioenergy, and biochemical industries. Education: B.S. Chemical Engineering, University of Notre Dame (2011) M.S. Chemical Engineering, North Carolina State University (2013) Ph.D. Chemical Engineering, North Carolina State University (2017) Postdoctoral Fellow, University of North Carolina Chapel Hill & Howard Hughes Medical Institute (2017-2021) Research Interests: The Conway Lab develops genetic engineering approaches for non-model bacteria at plant-microbe interfaces. Key research areas include: chemical signaling between plants and microbes, microbiome impacts on plant immunity, environmental stress responses in agricultural systems, and enzymatic degradation of lignocellulosic biomass using thermophilic bacteria. The lab employs bacterial genetics, systems biology, and biomolecular engineering to create technologies for sustainable bioindustries. Publication Trends: Recent work demonstrates strong emphasis on molecular mechanisms of plant-microbe communication (2020-2024), enzyme characterization in biomass degradation (2024-2025), and development of synthetic microbial communities for climate resilience (2024). Earlier research focused on extremophile enzymology and metabolic engineering (2012-2019). Student Advising: Currently mentors 4 graduate students and 8 undergraduates. Alumni include 9 former advisees who graduated between 2022-2024. The lab actively recruits students through Princeton's Chemical Engineering graduate program and undergraduate research initiatives. Laboratory: The Conway Lab develops microfluidic systems for root microbiome studies and genetic tools for engineering plant-associated bacteria. Current projects include designing thermophilic microbial consortia for consolidated bioprocessing and characterizing bacterial immune evasion strategies.

• Plant-microbe interactions
• Biomolecular engineering
• Systems biology
• +۴ مورد دیگر

Silvia Santos is a Group Leader at the Francis Crick Institute, leading the Quantitative Stem Cell Biology Lab since January 2018. Her research focuses on understanding cell decision-making during transitions, specifically cell division and differentiation in early development using human embryonic stem cells. She combines experimental techniques with theoretical approaches, including advanced microscopy, genomics, and computational modeling. Education and Career: PhD in Molecular and Cell Biology from EMBL-Heidelberg (2008), followed by postdoctoral training at Stanford University (2009-2014). She held an MRC Career Development Award at Imperial College London (2014-2017) before joining the Crick. Her work emphasizes interdisciplinary methods to study cellular processes in health and disease. Research Interests: Spatial-temporal control in cell decisions, stem cell differentiation, cell cycle regulation, and modeling embryonic development. She advocates for women in science and mentorship programs for early-career researchers. Key Achievements: Recipient of Marie Curie E-Star, EMBO, and HFSP fellowships. Recognized with the BioModels’ Model of the Year 2023 for contributions to systems biology. Her lab develops models like gastruloids to study embryonic development. Grants and Mentorship: Supported by MRC and other grants. Committed to fostering excellence in training and mentorship, previously chairing mentorship initiatives at Imperial College London. Labs and Teams: Quantitative Stem Cell Biology Lab at the Crick, collaborating with interdisciplinary teams on projects involving proteomics, genomics, and high-throughput screening.

• Developmental Biology
• Cell Biology
• Cell Cycle & Chromosomes
• +۳ مورد دیگر

Dana Pe'er is a Professor and Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute (SKI) of Memorial Sloan Kettering Cancer Center. She is also an Investigator of the Howard Hughes Medical Institute and holds the Alan and Sandra Gerry Endowed Chair. Dr. Pe'er leads an interdisciplinary research group that combines advanced genomics approaches with machine learning to address fundamental questions in biomedical science, with particular focus on cancer biology, developmental biology, and immunology. Dr. Pe'er earned her PhD from Hebrew University in Jerusalem, Israel. Her academic journey includes a postdoctoral fellowship with George Church at Harvard Medical School. Before joining Memorial Sloan Kettering Cancer Center in 2016, she held faculty positions at Columbia University. Dr. Pe'er's research focuses on understanding cellular plasticity, the consequences of intra-tumor heterogeneity, cancer evolution and metastasis, and the mechanisms by which regulatory circuits go awry in disease. Her lab combines single-cell and spatial profiling technologies with machine learning approaches to investigate gene regulation, cellular plasticity, and cell-cell communication in the contexts of cancer, immunity, and development. They are particularly interested in how organisms develop from a single cell to generate diverse cell types, how epigenetic control rewires during development, and how cells communicate to execute multicellular responses. Analysis of Dr. Pe'er's recent publications reveals a strong focus on developing computational methods for single-cell and spatial genomics data analysis. Her work spans cancer types including pancreatic, prostate, colorectal, and breast cancer, with emphasis on tumor heterogeneity, metastasis mechanisms, and cellular plasticity. A significant portion of her research involves creating novel algorithms and tools like CellRank, REUNION, and SEACells that enable researchers to extract meaningful biological insights from complex genomic datasets. 2023 Class of 2023 Inductee - American Academy of Cancer Research (AACR) Academy 2023 Innovator Award - International Society for Computational Biology (ISCB) 2021 Fellow - International Society for Computational Biology (ISCB) Howard Hughes Medical Institute Investigator (2021) 2019 Ernst W. Bertner Memorial Award - University of Texas MD Anderson Cancer Center 2016 Lenfest Distinguished Faculty Award - Columbia University 2014 Director's Pioneer Award - National Institutes of Health 2014 Overton Prize - International Society for Computational Biology (ISCB) Dr. Pe'er is known for her dedicated mentorship approach, describing herself as "a mama bear" who cares deeply about her trainees while expecting independence, innovation, and hard work. She mentors numerous PhD students and postdocs in her lab. Her HHMI Investigator award provides approximately $9 million over seven years, enabling ambitious research directions. She also collaborates extensively with the Single-cell Analytics and Innovation Lab (SAIL) at MSK to generate new data from emerging technologies, working closely with wet-lab collaborators at MSK and beyond to apply computational methods to cutting-edge datasets across multiple disease areas. The Pe'er Lab is an interdisciplinary group of computational biologists with diverse backgrounds ranging from pure mathematics to clinical medicine. They work closely with wet-lab collaborators to apply their computational methods to cutting-edge datasets across cancer, immunology, and developmental biology. The lab is described as open, supportive, collaborative, and fun, with access to world-class facilities at the Sloan Kettering Institute. Dr. Pe'er's work continues to push the boundaries of computational biology and cancer research, with the ultimate goal of developing more effective, personalized therapies for cancer patients.

• Cancer Biology
• Mathematical and Computational Modeling
• Bioinformatics
• +۷ مورد دیگر

Vibhu Sahni, Ph.D., is an Assistant Professor of Neuroscience and Lab Director of the Laboratory for Cell Fate Specification and Circuit Development at the Burke Neurological Institute, an affiliate of Weill Cornell Medicine. His research focuses on understanding molecular mechanisms underlying corticospinal circuit development and regeneration, particularly after injuries like spinal cord injury or stroke. His work integrates developmental neuroscience principles to identify strategies for repairing neural circuits involved in motor control. Research interests include axon guidance, segment-specific neural circuit formation, and the molecular basis of neural regeneration decline during development. Key projects investigate how genes like Cbln1 direct axon targeting to thoraco-lumbar regions and why long-distance regenerative ability varies across spinal segments. Recent publications highlight discoveries in segmental axon targeting specificity and the dynamic loss of regenerative capacity in corticospinal neurons. His lab employs advanced techniques such as single-cell RNA sequencing, in vivo electroporation, and microsurgical lesion models to study these processes. Current grants include funding from the Craig H. Neilsen Foundation and Wings for Life Spinal Cord Research Foundation to advance molecular strategies for corticospinal circuit repair.

• Neuroscience
• Neuroregeneration
• Motor Circuit Development
• +۳ مورد دیگر

Li Tang is an Associate Professor with tenure at École polytechnique fédérale de Lausanne (EPFL), affiliated with the Institute of Bioengineering (IBI) and the Institute of Materials Science and Engineering (IMX) within the School of Engineering (STI). She leads the Laboratory of Biomaterials for Immunoengineering, focusing on developing innovative strategies at the intersection of immunology, materials science, and cancer therapy. Her work bridges fundamental research and clinical translation, with multiple ongoing clinical trials based on CAR-T cell therapies developed in her lab. B.S. in Chemistry, Peking University (2003–2007) Ph.D. in Materials Science and Engineering, University of Illinois at Urbana-Champaign (2007–2012) Postdoctoral Fellow, MIT (2013–2016) Her research lies at the forefront of immunoengineering, integrating chemical, metabolic, and mechanical approaches to modulate immune responses. Key areas include cancer immunotherapy, immune metabolism, mechano-immunology, and biomaterials. She investigates how physical and biochemical cues can reprogram T cells, overcome exhaustion, and enhance tumor targeting. Her work emphasizes multidimensional immunity-disease interactions, aiming to develop safer and more effective therapies for cancer and autoimmune diseases. The recent publications highlight a strong trend in engineering immune cells (especially CAR-T) for enhanced durability and function, using advanced biomaterials and metabolic reprogramming. There is a clear focus on overcoming challenges in solid tumors, modulating the tumor microenvironment, and translating findings into clinical applications. The use of nanoparticle delivery, single-cell analysis, and biomechanical cues are recurring themes across her work. Notable scientific awards include: Friedrich Miescher Award (2025) ERC Starting Grant (2018) MIT TR35 Innovators Under 35 (China Region, 2020) Nano Research Young Innovator Award (2018) Biomaterials Science Emerging Investigator (2019) Materials Horizons Emerging Investigator (2020) Li Tang actively mentors PhD students across multiple doctoral programs (EDBB, EDMS, EDMX) and has advised numerous graduates who have gone on to prestigious postdoctoral and faculty positions. She is involved in significant research grants, including an Innosuisse project with Novochizol SA, and her lab is supported by competitive funding. She teaches core courses such as Immunoengineering and Next-Generation Biomaterials, shaping the next generation of scientists. Her lab fosters interdisciplinary collaboration and innovation, with active projects in chemical, metabolic, and mechanical immunoengineering, as well as CAR-T cell development. She is the Principal Investigator of the Tang Lab, which includes postdoctoral fellows, PhD students, and technical staff. The lab is actively recruiting and has a strong publication and clinical translation record. Tang Lab is also involved in multiple MA/BA training projects and promotes student engagement in cutting-edge research. The lab’s discoveries are being translated into clinical trials, reflecting a strong commitment to translational science.

• Immunoengineering
• Cancer Immunotherapy
• Immune Metabolism
• +۷ مورد دیگر

Hans Christopher Bernstein is a Professor at the Norwegian Fisheries College, UiT The Arctic University of Norway, and affiliated with the Arctic Centre for Sustainable Energy (ARC). His research focuses on biotechnology, microbial ecology, synthetic biology, and microalgal carbon capture and utilization. University: UiT The Arctic University of Norway School: Norwegian Fisheries College Research Group: Microalgae & Microbiomes Research Centers: Arctic Centre for Sustainable Energy (ARC) Bernstein’s work explores the intersection of biotechnology and microbial ecology, particularly in synthetic biology applications for carbon capture. His research includes modeling microbial processes, studying lipidome plasticity in Arctic diatoms, and developing engineered genetic circuits for microbial consortia. Key trends in his publications involve marine microbiome dynamics, cold seep ecosystems, and daylight-driven carbon exchange in structured microbial communities. Recent articles highlight advancements in microalgal biotechnology for industrial carbon capture, synthetic genetic circuits, and spatiotemporal metabolic network models. His work spans both theoretical modeling (e.g., neighbor-dependent interaction inference) and applied biotechnological solutions (e.g., EcoFABS fabricated ecosystems).

• Biotechnology
• Microbial Ecology
• Synthetic Biology
• +۳ مورد دیگر

Jessica E. Treisman is a Professor in the Department of Cell Biology and Department of Ophthalmology at NYU Grossman School of Medicine. Her research focuses on developmental genetics and molecular neuroscience, particularly in the context of visual system development and synapse formation in Drosophila . Research Interests: Cell fate determination, tissue morphogenesis, neural circuit assembly, and corneal lens development Contact: Jessica.Treisman@nyulangone.org | 212-263-1031 Lab: Treisman Lab, Skirball Institute, New York, NY Her work explores how intrinsic transcription factors and extrinsic signaling pathways interact to regulate cell differentiation and tissue organization in the Drosophila visual system, with implications for understanding human corneal development and neural connectivity disorders. Recent publications highlight her contributions to understanding: Molecular mechanisms of corneal lens curvature formation Regulation of synaptic targeting specificity Role of Sidekick in epithelial junction dynamics Transcriptional synergy between Glass and EGFR signaling The Treisman Lab employs interdisciplinary approaches in Drosophila genetics to uncover fundamental principles of cell signaling and neural circuit development, with potential applications in human vision research and developmental disorders.

• Developmental genetics
• Cell signaling
• Synapse formation
• +۵ مورد دیگر

Jessica J. Walsh, PhD is an Assistant Professor in the Department of Pharmacology at the University of North Carolina at Chapel Hill School of Medicine and a member of the UNC Neuroscience Center. She leads the Walsh Lab, which focuses on understanding neural circuit mechanisms underlying motivated social behavior using a multi-level approach to elucidate the molecular and circuit mechanisms that govern social interactions and their alterations in disease states. Dr. Walsh earned her B.A. in Neuroscience & Behavior from Columbia University, where she began her research journey volunteering in Dr. Gerald Fischbach's laboratory. During her graduate work, she explored neural circuit mechanisms underlying social stress susceptibility at the Icahn School of Medicine at Mount Sinai under Dr. Ming-Hu Han. Prior to joining UNC, she completed her postdoctoral fellowship at Stanford University with Dr. Robert Malenka, investigating neural circuit mechanisms in genetic mouse models with social deficits. Her research focuses on neural circuit mechanisms underlying motivated behavior, neurodevelopmental and psychiatric disorders, and functional/anatomical brain mapping. The Walsh Lab specifically uses genetic mouse models to investigate how genetic mutations and experience lead to circuit adaptations that govern impaired behavior seen in autism spectrum disorders. They combine whole brain optical clearing methods, light sheet microscopy, in vivo imaging, and machine learning based behavioral analysis to elucidate neural adaptations responsible for motivated behavior. Her publication record demonstrates a strong focus on neural circuits related to social behavior, with particular emphasis on autism spectrum disorders, serotonin and dopamine signaling, and the neural basis of prosocial behaviors. She has published extensively in high-impact journals including Nature, Nature Neuroscience, PNAS, and Neuropsychopharmacology, with research spanning from molecular mechanisms to circuit-level analyses of behavior. Dr. Walsh mentors several trainees in her lab, including a postdoctoral fellow, multiple graduate students, and numerous undergraduate researchers. Her lab team includes researchers with diverse interests spanning from molecular biology to machine learning applications in neuroscience. The lab actively recruits postdocs and graduate students interested in joining their research on motivated behavior and psychiatric disorders. The Walsh Lab employs a comprehensive research approach including genetic manipulation, whole brain activity mapping, viral tracing, slice physiology, optogenetics, chemogenetics, fiber photometry, and machine learning based behavioral classification to gain a nuanced understanding of neural circuits involved in motivated social behavior.

• Neural Circuits
• Motivated Behavior
• Social Behavior
• +۴ مورد دیگر

Kuo-Fen Lee, PhD is a Professor at the Salk Institute for Biological Studies, holding the prestigious Helen McLoraine Chair of Molecular Neurobiology. He leads the Clayton Foundation Laboratories for Peptide Biology, where his research focuses on nerve regeneration, spinal cord injury, and molecular mechanisms underlying neural development and neurodegenerative diseases. His work bridges basic neuroscience with potential therapeutic applications for conditions like ALS, paralysis, and Alzheimer's disease. Dr. Lee received his educational training from multiple prestigious institutions: a degree in Plant Pathology from National Taiwan University; an MS in Cancer Enzymology and Cell Differentiation from National Yang-Ming Medical College, Taiwan; a PhD in Endocrinology from Baylor College of Medicine, Houston; and completed his postdoctoral training at the Whitehead Institute for Biomedical Research. His primary research interests center on understanding why humans cannot regenerate damaged nerves while many other animals can. Dr. Lee has made significant discoveries regarding the p45 protein, which promotes nerve regrowth in mice but is absent in humans (who instead have p75, which inhibits nerve growth). His laboratory also studies neuregulin signaling, neuromuscular synapse formation, and the role of various proteins like nestin in neural development and maintenance. His work often employs mouse models to investigate spinal cord injury, pain pathways, and neurodegenerative conditions. Analysis of Dr. Lee's recent publications reveals a consistent focus on molecular neurobiology with particular emphasis on neural signaling pathways, synaptic maintenance, and nerve regeneration mechanisms. His research spans from basic molecular mechanisms to potential therapeutic applications, with increasing attention to pain pathways, Alzheimer's disease models, and the intersection of neuroscience with immunology and metabolism in recent years. As holder of the Helen McLoraine Chair of Molecular Neurobiology, Dr. Lee has received significant institutional recognition for his contributions to neuroscience. While specific awards aren't detailed in the provided text, his sustained funding and leadership position indicate substantial peer recognition in his field. Dr. Lee's research program involves extensive collaboration with other neuroscience laboratories, as evidenced by his numerous co-authored publications across various neuroscience subdisciplines. His work has been consistently funded, allowing for the maintenance of an active research laboratory focused on nerve regeneration and molecular neurobiology. The Clayton Foundation Laboratories for Peptide Biology serves as the primary research environment for Dr. Lee's team, where they investigate molecular mechanisms of nerve development, regeneration, and degeneration using advanced genetic, molecular, and cellular approaches. The laboratory maintains active research programs in multiple areas of neural signaling and development.

• Molecular Neurobiology
• Nerve Regrowth
• Spinal Cord Injury
• +۵ مورد دیگر

Andrew J. Todd is a Professor and Honorary Fellow in the School of Psychology & Neuroscience at the University of Glasgow. His research focuses on neurochemistry and synaptic connections in the mammalian spinal cord, particularly the organization of neuronal circuits underlying pain and itch perception. He employs techniques like immunocytochemistry, confocal microscopy, and electron microscopy. Collaborations include researchers from institutions such as UCL, Saga University, and the University of Pittsburgh. His work is funded by the Wellcome Trust and BBSRC. Roles: Professor, Honorary Fellow Affiliations: School of Psychology & Neuroscience, University of Glasgow Research Interests Dr. Todd investigates spinal dorsal horn circuits, including projection neurons, interneurons, and synaptic plasticity. Key topics include: Neurochemical characterization of spinal neurons Role of neuropeptides like substance P and gastrin-releasing peptide Mechanisms of neuropathic pain and spinal circuit adaptations Functional roles of specific neuron populations in laminae I-III Articles Overview Recent work includes studies on spinal projection neuron markers (e.g., Tacr1, Gpr83), synaptic circuits involving GRP-expressing neurons, and interneuron subtypes' roles in pain/itch. Notable findings include the absence of neuronal loss in neuropathic pain models and the identification of novel spinal circuits. Grants & Funding Funded by the Wellcome Trust and BBSRC . Collaborations span international institutions, emphasizing spinal neurobiology and sensory processing.

• Neurochemistry
• Neuroscience
• Pain Research
• +۳ مورد دیگر

Kristen Pleil is an Associate Professor at Weill Cornell Medicine in the Graduate School of Medical Sciences, affiliated with the Department of Pharmacology and Neuroscience. She serves as Co-director of the NIGMS-sponsored Training in Pharmacological Sciences (TIPS) predoctoral T32 program. Academic Appointments: Assistant Professor (2016), Associate Professor (2021) Education: BA in Psychology (Emory University, 2005), PhD in Neuroscience (Duke University, 2010), Postdoc at University of North Carolina School of Medicine Research Focus: The Pleil lab investigates how sex and stress hormones regulate alcohol/substance use, stress responsivity, and affective behavior through neuropeptidergic brain circuits and hormone-neuropeptide signaling. Key projects include estrogen's role in alcohol drinking and anxiety, opioid receptor signaling in reward/aversion learning, and sex-dependent thalamic control of stress responses. The lab uses in vivo and ex vivo mouse models to study synaptic/epigenetic plasticity across developmental stages. Publications Trends: Her work spans molecular pharmacology, neurophysiology, and addiction research with a focus on sex differences in neuropsychiatric diseases. Articles cover topics like estrogen signaling in binge drinking, opioid-context memory, thalamic circuits in stress response, and optogenetic tools for receptor imaging. Scientific Awards: President’s Young Investigator Award, ISBRA (2013) Elizabeth Young New Investigator Award, OSSD (2015) K99/R00 Pathway to Independence Award, NIAAA (2015) Kellen Foundation Junior Faculty Fellowship (2016) NARSAD Young Investigator Award (2017) Early Career Investigator Award, NIDA-NIAAA (2017) Training and Collaborations: As Co-director of the TIPS T32 program, she mentors graduate students in pharmacological sciences. Her collaborations include researchers at UNC, Duke, and Weill Cornell, with grants from NIAAA, NIMH, and NIGMS.

• Neuroscience
• Pharmacology
• Neuropharmacology
• +۴ مورد دیگر