جست‌وجوی استاد و پژوهشگر

Eili Tranheim Kaseمشاهده پروفایل

دانشیار

• Pharmacology
• Physiology
• Type 2 Diabetes
• +۵ مورد دیگر

Eili Tranheim Kase is a Professor and current Associate Professor at the University of Oslo , affiliated with the Department of Pharmacology and Pharmaceutical Biosciences . Her research focuses on energy metabolism in human skeletal muscle cells, particularly its role in the pathophysiology of Type 2 diabetes and obesity . She actively teaches pharmacology, physiology, and pharmacotherapy at both bachelor's and master's levels. Education: Cand.pharm. (2002), University of Oslo PhD (2007), University of Oslo Her research explores mechanisms like the LXR pathway , SENP2 regulation , and AMPK function in metabolic disorders, with recent work on myotube models for drug testing and 3D culture systems . Key article trends include lipid-glucose interactions , exercise mimetics , and nutraceutical effects on muscle metabolism. Scientific Awards: Fulbright Research Scholar (2022/2023) She supervises master's and PhD students and collaborates with Professor Christopher Glass at UCSD. Her work is part of the MetHealth research group, which investigates metabolic regulation in health and disease.

• Protein Homeostasis
• RNA Quality Control
• Post-transcriptional Gene Regulation
• +۳ مورد دیگر

Wali Karzai is a Professor and Chair in the Department of Biochemistry and Cell Biology at Stony Brook University. His research focuses on understanding mechanisms of protein and RNA homeostasis in bacteria, particularly through studies of tmRNA-mediated trans-translation, nonstop mRNA decay, and directed proteolysis. He leads an active lab with graduate students, postdocs, and undergraduates. Key research areas include: (1) Adaptor-guided proteolysis by AAA+ proteases like Lon, (2) Ribosome-associated quality control of nascent polypeptides, and (3) mRNA decoding and decay pathways. His work combines protein biochemistry, structural biology, and functional genomics. Notable contribution: Identified the role of SmpB protein in tmRNA binding and ribosome rescue. Investigated the virulence role of tmRNA systems in pathogens like Yersinia and Francisella. Recipient of the 2003 Pew Biomedical Scholars award. Current projects explore Lon protease substrate recognition, RNase R targeting mechanisms, and physiological significance of tmRNA systems in bacterial pathogenesis.

• Type 1 Diabetes
• Endocrinology
• Clinical Chemistry
• +۵ مورد دیگر

Annelien Van Dalem serves as a Clinical Professor in the Department of Clinical Biology within the Faculty of Medicine and Pharmacy at Vrije Universiteit Brussel. Her clinical practice is based at University Hospital Brussels (UZB) where she maintains dual expertise in Pharmaceutical and Pharmacological Sciences alongside Clinical Biology. With an ORCID identifier (0000-0003-2304-5298) and active research profile through 2025, she represents a key figure in diabetes research and clinical laboratory medicine at this Belgian academic institution. Dr. Van Dalem's research program centers on Type 1 Diabetes Mellitus with 100% research footprint concentration according to institutional metrics. Her work specifically investigates autoantibodies (64% research footprint), C-Peptide dynamics (64%), and therapeutic responses to agents like otelixizumab (49%). Additional expertise includes Zinc Transporter 8 (30%), Ion-Selective Electrode technology (24%), and Glucose monitoring systems (22%). Her laboratory focuses on early biological markers for diabetes prediction, complications assessment, and contribution to prevention trial design through epidemiological approaches. Analysis of her publication record reveals a clear research trajectory spanning clinical chemistry methodology and diabetes pathophysiology. Recent work demonstrates increasing focus on continuous glucose monitoring technologies and therapeutic response prediction, while maintaining strong contributions to analytical interference issues in laboratory medicine. Her collaborative network includes major diabetes research groups across Belgium with significant work on otelixizumab trials and beta cell function preservation. Scientific recognition includes: Award 'Bank J. Van Breda & C°' (2011) Dr. Van Dalem actively supervises graduate research, most recently co-advising Janssens, A.'s 2024 Master's thesis on maglumi X3 platform validation for multiple analytes. Her institutional activities show extensive participation in professional development through 66 recorded events (2017-2025), including 32 conference participations and 29 workshop engagements. Current activities focus on AI applications in clinical biology, viral hepatitis diagnostics, HLA typing, and multiple myeloma diagnostics. Her laboratory maintains dual research streams: one focused on diabetes biomarker discovery and validation, and another addressing analytical challenges in clinical chemistry including biotin interference and ion-selective electrode measurement accuracy. Recent collaborative work extends into cardiovascular outcomes research as evidenced by the 2025 FFRCT registry analysis.

• Microbiology
• Infectious Diseases
• Host-Pathogen Interactions
• +۶ مورد دیگر

Dr. Barbara Kazmierczak is a Professor of Medicine and Microbial Pathogenesis at Yale School of Medicine, with appointments in Infectious Diseases and Microbial Pathogenesis. She directs Yale's MD-PhD program and investigates bacterial pathogenesis mechanisms in Pseudomonas aeruginosa infections. Her work bridges clinical and basic science research through the American Society for Clinical Investigation and American Academy for Microbiology fellowships. Education: PhD (Rockefeller University, 1993), MD (Cornell University Medical College, 1994) Departments: Medicine (Infectious Diseases), Microbial Pathogenesis Leadership: MD-PhD Program Director, Vice Chair for Basic Research Her research program focuses on Pseudomonas aeruginosa virulence mechanisms, including Type 3 secretion systems, Type 4 pili, and polar flagellum dynamics during infection. She explores host responses like NLRC4 inflammasome activation and longitudinal microbiome-host interactions in cystic fibrosis infants. Her lab develops novel antimicrobial approaches through personalized bacteriophage therapy. Notable scientific awards include Burroughs-Wellcome Fund Investigator (2007), Donaghue Investigator (2002), and Hellman Family Fellow (2002). She holds leadership roles in educational initiatives including the Yale Biomed Amgen Scholars Program and Yale Combined Program in Biological Sciences. Dr. Kazmierczak's recent publications highlight advancements in phage therapy for multidrug-resistant Pseudomonas , bacterial surface characterization methods, and microbiome chemical interactions. Her work addresses critical gaps in antibiotic resistance mechanisms and physician-scientist training optimization. Lab affiliations: Whisk Lab Center for Pulmonary Injury, Inflammation, Repair and Therapeutics (CPIRT) Yale Center for Infectious Disease Modeling and Analysis

• Cancer Immunology
• Tumor Microenvironment
• MicroRNA Diagnostics
• +۴ مورد دیگر

Kathrin Tyryshkin serves as an Adjunct Assistant Professor at Queen's University, holding a Ph.D. earned in 2014. Her academic affiliation centers within medical research domains though specific school or departmental structure isn't explicitly documented in available materials. Her research spans Cancer Immunology , Tumor Microenvironment , and MicroRNA Diagnostics , with significant focus on bladder cancer mechanisms, macrophage-T cell interactions, and liquid biopsy development. Recent work demonstrates expertise in machine learning applications for molecular classification and STING pathway immunotherapies. Publications reveal consistent investigation into sex differences in cancer models and epigenetic regulation of immune responses. Analysis of her 15 most recent publications (2022-2025) shows dominant themes in Macrophage-mediated tumor immunity (4 papers) MicroRNA-based cancer diagnostics (3 papers) Sex/age-related immune variations in bladder cancer (3 papers) STING pathway therapeutics (2 papers) Machine learning for molecular classification (2 papers) indicating a trajectory toward computational oncology integrated with wet-lab immunology. Her advising activities and grant funding aren't documented in available materials. No scientific awards or fellowships are mentioned in the provided texts.

Ashleigh Griffinمشاهده پروفایل

استاد

• Evolutionary Biology
• Social Evolution
• Bacterial Cooperation
• +۲ مورد دیگر

Professor Ashleigh Griffin holds the position of Professor of Evolutionary Biology at the University of Oxford. Her research examines fundamental questions about cooperative behavior evolution across biological systems, from microbial communities to vertebrate societies. Research integrates theoretical frameworks with experimental approaches to understand how cooperation evolves despite inherent conflicts. Current projects investigate: 1) Bacterial social evolution applied to antibiotic resistance and infection dynamics 2) Cooperative breeding systems in birds under environmental variability 3) Conflict resolution mechanisms enabling evolutionary transitions to multicellularity. Laboratory work utilizes Pseudomonas aeruginosa models while field studies analyze cooperative bird species. Publications demonstrate consistent innovation in social evolution theory, spanning microbial cooperation, vertebrate behavioral ecology, and clinical applications. Recent articles reflect expanded focus on environmental variability's role in cooperation, evolutionary medicine approaches to infection treatment, and developmental innovations reducing cellular conflicts. Honors include the 2008 UNESCO/L'Oréal Fellowship for Women in Science, recognizing exceptional contributions to evolutionary biology research.

Karl Kadlerمشاهده پروفایل

استاد

• Extracellular Matrix Biology
• Collagen Fibrillogenesis
• Circadian Rhythms
• +۷ مورد دیگر

Karl Kadler is a Professor of Biochemistry at the University of Manchester in the UK, serving as Director of both the Wellcome Trust Centre for Cell-Matrix Research and the Cellular & Developmental Systems Domain within the Faculty of Biology, Medicine and Health. He holds a PhD in Medical Biophysics from the University of Manchester (1984) and a BSc (Hons) in Biochemistry from the University of Salford (1980). His research focuses on collagen fibril assembly mechanisms, extracellular matrix biology, and the role of circadian rhythms in tissue maintenance. Kadler pioneered the use of serial block face-scanning electron microscopy (SBF-SEM) in the UK and discovered fibripositors—actin-based plasma membrane structures critical for collagen fibril formation and mechanosensing. His work bridges molecular biology, biochemistry, and advanced imaging to study diseases like osteogenesis imperfecta and Ehlers-Danlos syndrome. Research interests include circadian regulation of collagen homeostasis, extracellular matrix turnover dynamics, and the interplay between mechanical forces and cellular processes. Recent studies highlight circadian-driven protective mechanisms for collagen and macrophage-fibroblast interactions in fibrosis. Kadler’s expertise aligns with UN Sustainable Development Goals related to health and innovation. He has received the prestigious 2016 Fell-Muir Prize for contributions to extracellular matrix research and manages large-scale interdisciplinary projects including the NIHR Manchester Biomedical Research Centre and the Centre for Biological Timing. His work has produced over 124 publications and 3 notable datasets, demonstrating methodological innovations in collagen imaging and circadian biology.

Weikang Caiمشاهده پروفایل

دانشیار

• Diabetes Research
• Neurodegenerative Diseases
• Insulin Signaling
• +۴ مورد دیگر

Weikang Cai, PhD, is an Associate Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky. He is affiliated with the Sanders-Brown Center on Aging. His research focuses on the intersection of diabetes, insulin resistance, and neurological disorders, particularly Alzheimer's disease and major depression. Dr. Cai's work emphasizes astrocyte function, insulin signaling pathways, and their roles in metabolic regulation and neurobehavioral outcomes. He has pioneered studies on astrocyte-derived ATP signaling's impact on amyloid pathology and dopamine circuits linked to mood disorders. Education includes a BS from Nanjing University (China), PhD from University of Kentucky College of Medicine, and postdoctoral training at the Joslin Diabetes Center, Harvard Medical School. His lab employs interdisciplinary approaches including biochemistry, molecular biology, and systems biology to address comorbidities between metabolic and neurological conditions. Key research themes include: 1) Astrocytes in brain metabolism and diabetes, 2) ATP signaling in Alzheimer's amyloid pathology, and 3) Astrocyte roles in dopamine circuits and depression. His publications span 2011-2025, reflecting sustained contributions to metabolic-neurological interface research. Publications consistently highlight novel insights into insulin signaling mechanisms, astrocyte biology, and translational strategies for treating metabolic-neurological comorbidities. His work bridges basic science and clinical relevance, addressing major public health challenges like Alzheimer's and diabetes-related complications.

Vanessa Sperandioمشاهده پروفایل

استاد

• Microbial Pathogenesis
• Host-Pathogen Interactions
• Inter-Kingdom Signaling
• +۱۲ مورد دیگر

Vanessa Sperandio is a Professor and Chair of the Department of Medical Microbiology and Immunology at the University of Wisconsin–Madison, School of Medicine and Public Health. She leads a dynamic research lab focused on understanding how enteric pathogens sense and respond to chemical signals from the host and gut microbiota to regulate virulence and colonization. Her research centers on inter-kingdom chemical signaling, particularly the gut-brain axis, where bacterial pathogens like EHEC and Citrobacter rodentium detect host neurotransmitters (e.g., epinephrine, norepinephrine, serotonin) and microbiota-derived molecules (e.g., AI-3, indole, fucose, galacturonic acid, arginine) to modulate virulence. Key discoveries include identifying bacterial receptors such as QseC, CpxA, and FusK, which integrate host and microbial signals, revealing novel mechanisms of pathogenesis and potential anti-virulence therapeutic strategies. Her work also explores how drug use, such as cocaine, alters gut microbiota and host metabolism, influencing neurobehavioral responses. The recent publications highlight a strong focus on nutrient sensing (e.g., arginine, galacturonic acid), bacterial signal transduction, and the role of microbiota in modulating infection and behavior. Her research spans molecular microbiology, host-pathogen interactions, and neuroimmunology, with implications for infectious disease and addiction. Dr. Sperandio mentors a diverse team of postdoctoral fellows, PhD students, and undergraduates. Former lab members have advanced to faculty positions, indicating her strong mentorship. Her lab is equipped for molecular, cellular, and in vivo studies, supporting high-impact research. She has made significant contributions to understanding how pathogens exploit host and microbial signals, translating basic science into potential therapies. Her work bridges microbiology, neuroscience, and immunology, positioning her at the forefront of interdisciplinary research in host-microbe interactions.

Robert Reidمشاهده پروفایل

پژوهشگر ارشد

• Histone Deacetylation
• Immunology
• Drug Discovery
• +۴ مورد دیگر

Dr. Robert Reid is a Senior Postdoctoral Fellow at the Institute for Molecular Bioscience, University of Queensland. His research focuses on epigenetic regulation, immunology, and drug discovery, particularly targeting histone deacetylases (HDACs), complement proteins, and protease inhibitors. He has contributed to understanding HDAC7's role in immunometabolic pathways and macrophage function, with recent work emphasizing anti-inflammatory agents and antiparasitic drug development. Key research areas include the interplay between HDAC enzymes and cellular metabolism, bacterial virulence mechanisms, and the design of small-molecule inhibitors. His publications span over two decades, with notable contributions to malaria drug discovery and the structural biology of HIV protease inhibitors. Dr. Reid collaborates extensively with teams exploring macrophage biology, bacterial pathogenesis, and translational drug development. His work has advanced the understanding of how HDAC inhibitors modulate immune responses and metabolic pathways, with potential applications in treating inflammatory diseases, cancer, and infectious diseases. He holds patents related to HDAC inhibitors and complement receptor antagonists, reflecting his focus on translational research.

• Virology
• Immunology
• Microbiology
• +۹ مورد دیگر

Ana Fernandez-Sesma is a Professor in the Department of Microbiology and the Division of Infectious Diseases within the Department of Medicine at the Icahn School of Medicine at Mount Sinai. Her research focuses on understanding how human pathogens, particularly dengue and influenza viruses, interact with and evade the human innate immune system. She leads a dynamic laboratory that investigates viral immune evasion mechanisms in primary human immune cells, including dendritic cells and macrophages. Her research interests include: Viral immune evasion strategies Innate immunity to flaviviruses (especially dengue virus) Influenza virus-host interactions Recombinant virus generation Viral adaptation in human and mosquito cells Host-pathogen interactions in viral infections The laboratory's recent publications reflect a strong emphasis on molecular virology and immunology, particularly the mechanisms by which viral proteins such as NS2B/3, NS5, and NS1 interfere with host signaling pathways like STING, RIG-I, and NF-κB to suppress interferon production and promote viral replication. Her work also explores vaccine development and cross-reactive immunity between related viruses like dengue and Zika. Scientific awards include: Best Faculty Mentor to Postdoctoral Fellows, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai (2013) Ana Fernandez-Sesma has mentored a number of junior scientists, including postdoctoral fellows (Ana Maestre, Rafael Fenutria-Aumesquet, Paula Lopez-Monteagudo), junior faculty (Irene Ramos, Sebastian Aguirre), and graduate students (Edwin Carbajal, Jessica Pintado-Silva, Tong-Tong Zhu, Gabe Webb). Her lab has received funding from sources such as DARPA for collaborative projects on viral adaptation. She is actively involved in the Multi-Disciplinary Training Area in Immunology and Microbiology at Mount Sinai and contributes to graduate education and training. She also oversees research personnel such as Dabeiba Bernal-Rubio and Uma Potla, and has trained past members including Rebecca Hamlin, Kevin Maringer, and Timothy Savage. Her lab maintains a strong presence in the scientific community, with ongoing research into the fundamental biology of emerging viral pathogens and their interactions with the human immune system.

• Asthma research
• Airway inflammation
• Eosinophilia
• +۶ مورد دیگر

Dr. Roma Sehmi is a Professor in the Department of Medicine at McMaster University's Faculty of Health Sciences. Her research focuses on mechanisms of airway inflammation in asthma, with particular emphasis on hemopoietic processes in the development of airway eosinophilia and the role of innate lymphoid cells in driving asthma exacerbations. Dr. Sehmi received her PhD from the Royal Brompton National Heart and Lung Institute, Imperial College (London, UK) and completed post-doctoral fellowship training at Cambridge University, UK and McMaster University. Her educational background has provided a strong foundation for her research in respiratory immunology and inflammation. Dr. Sehmi's research interests center on understanding cellular mechanisms in asthma and allergic diseases. She has developed methodologies to enumerate and phenotype rare cells in cord blood, bone marrow, blood and airway secretions to understand cell migration during asthmatic responses. Her current work investigates alarmin and neuro-immune pathways regulating pathobiological interactions in asthma and chronic obstructive pulmonary disease. She examines sputum, blood and bone marrow aspirates to understand cross-compartmental effects following allergen exposure and the mechanistic effects of novel biologic therapies. Dr. Sehmi's work has received funding from national and provincial granting agencies, and she holds several investigator-initiated grants. She has published over 100 peer-reviewed articles with more than 6100 citations and an h-index of 42 according to Google Scholar. Her research shows a consistent focus on cellular immunology of asthma, with recent work expanding into biologic therapies, innate lymphoid cells, and connections between respiratory and skin manifestations of allergic disease. Ontario Lung Association award for research excellence Fellow of the American Academy of Allergy, Asthma and Immunology (AAAAI) Inducted member of the Collegium Internationale Allergologicum (CIA) Dr. Sehmi is an active mentor, training graduate and post-doctoral fellows while serving as an area coordinator in the Health Science Graduate program at McMaster University. She teaches undergraduate and graduate courses including "Pathophysiology of Lung Diseases - Asthma and COPD" and "Health Science Communication." As a member of the Clinical Investigator Collaborative, she accelerates testing of investigational medications through Phase IIa-IIb proof-of-concept studies in asthma. Her laboratory work focuses on cellular mechanisms of airway inflammation, with particular expertise in rare cell enumeration and phenotyping across multiple compartments (blood, bone marrow, airways). Her team investigates how cellular responses differ between various inflammatory phenotypes of respiratory disease.

E Matthew Morrisمشاهده پروفایل

استادیار

• Energy Metabolism
• Mitochondrial Physiology
• Metabolic Diseases
• +۵ مورد دیگر

E Matthew Morris is an Assistant Professor in the Department of Molecular and Integrative Physiology at the University of Kansas Medical Center . His research focuses on liver mitochondrial energy metabolism and its role in systemic metabolic health, particularly in obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Education : PhD in Nutrition and Exercise Physiology (2011) from the University of Missouri, Columbia Training : Postdoctoral Fellowships at the University of Missouri (2011-2015) and University of Kansas Medical Center (2015-2020) Morris explores how mitochondrial function in the liver interacts with neural pathways to regulate energy homeostasis and sex differences in diet-induced weight gain. His work also examines transcriptional control of mitochondrial lipid metabolism in the ventromedial hypothalamus. Key trends in his publications include sex-specific adaptations to high-fat diets, mitochondrial-lysosome interactions , and exercise-induced metabolic reprogramming . His studies often use rodent models to dissect mechanisms linking mitochondrial physiology to systemic disease. Scientific Awards : NIH Mentored K01 NIDDK award (2017) to study liver energy metabolism in acute high-fat/high-sucrose feeding Morris collaborates extensively with Dr. John Thyfault and investigates interventions like bile acid sequestrants, exercise training, and diet modifications. He leads his own laboratory as principal investigator since 2020, focusing on translational approaches to metabolic disease prevention.

• Plant Pathology
• Plant-Microbe Interactions
• Plant Phenotyping
• +۵ مورد دیگر

Dr. Valerian Meline is a Researcher in the Plant-Microbe Interactions group within the Department of Biology at the Faculty of Science, Utrecht University. His work focuses on understanding plant-pathogen interactions, particularly bacterial wilt disease in tomatoes, and developing advanced imaging techniques for plant phenotyping. Dr. Meline's research spans plant pathology, plant-microbe interactions, and plant phenotyping using cutting-edge imaging technologies. He investigates molecular and physiological defense mechanisms against pathogens like Ralstonia solanacearum and Xanthomonas , with emphasis on biotic-abiotic stress interplay. His methodology integrates X-ray computed tomography for root architecture analysis and chlorophyll fluorescence imaging for disease detection, revealing growth-defense trade-offs and stress tolerance mechanisms. Analysis of Dr. Meline's publication trends shows a clear evolution from chlorophyll fluorescence-based effector phenotyping (2016-2019) toward advanced 3D/4D root modeling and AI-driven disease progression assessment (2021-2023). Key advancements include volumetric segmentation algorithms, trehalose-mediated cross-tolerance discoveries, and genetic loci identification for bacterial resistance through image-based quantitative trait analysis. Dr. Meline operates within Utrecht University's Plant-Microbe Interactions research group, which employs multidisciplinary approaches combining molecular biology, genetics, and computational imaging to decode plant-microbe communication. The group's work targets sustainable crop protection strategies through fundamental insights into plant immunity and pathogen virulence mechanisms.

• Innate Immunity
• Microbial Pathogenesis
• Inflammasome Activation
• +۵ مورد دیگر

Dr. Dario S Zamboni is a Professor at the Ribeirão Preto Medical School, University of Sao Paulo (USP), where he leads the Innate Immunity and Microbial Pathogenesis laboratory. He earned his Ph.D. in Microbiology, Immunology, and Parasitology from the Federal University of São Paulo (UNIFESP) and completed postdoctoral training at Yale University School of Medicine (2003–2006). Key Research Areas: Innate Immunity, Inflammasome Activation, Host-Pathogen Interactions, Microbial Pathogenesis, Cell Death Regulation His recent publications focus on immune responses to bacterial and viral infections, including studies on Legionella pneumophila, Leishmania, and SARS-CoV-2. His work spans molecular mechanisms of inflammasome activation, immune evasion strategies, and the role of DNA sensors like AIM2 in inflammatory diseases. Despite active editorial contributions (e.g., Specialty Chief Editor for Parasite Immunology at Frontiers in Immunology), no scientific awards or students are explicitly listed here.