جست‌وجوی استاد و پژوهشگر

• Reproductive Biology
• Preterm Labor Mechanisms
• Uterine Contractility
• +۴ مورد دیگر

Heather Burkin, Ph.D., is an Associate Professor in the Department of Pharmacology at the University of Nevada, Reno, where she leads an active research program focused on the molecular mechanisms governing uterine contractility and the pathophysiology of preterm labor. Education B.A. in Biology, University of Colorado, Boulder Ph.D. in Animal Sciences (Reproductive Biology), University of Illinois, Urbana Research Interests Dr. Burkin’s laboratory investigates the cellular and molecular factors that regulate the onset of labor, with the overarching goal of reducing neonatal morbidity linked to spontaneous preterm birth. Using state-of-the-art tissue-engineering approaches, her team creates synthetic three-dimensional myometrial tissue models that replicate both normal and pathological pregnancy conditions. Central to her work is the study of matrix metalloproteinases—particularly MMP-2 and MMP-9—and their roles in modulating uterine contractility via remodeling of the extracellular matrix and intracellular signaling cascades. Additional foci include the impact of maternal obesity on long-term childhood respiratory outcomes and the nitric-oxide-mediated pathways that govern myometrial quiescence and activation. Publication Trends Across her extensive publication record, a clear trajectory emerges: from early molecular characterizations of gamete recognition and integrin biology to a concentrated emphasis on the biochemical underpinnings of preterm labor. Recent works highlight translational strategies—pharmacological inhibition of MMP-9, prostaglandin-driven contractility testing in engineered tissues, and epidemiological analyses linking maternal BMI to childhood asthma—demonstrating an integrative approach that bridges bench discoveries to potential clinical interventions. Scientific Awards No specific awards or honors are listed in the provided text. Current Funding & Collaborative Networks The text does not enumerate active grant numbers or named trainees; however, the sustained output in high-impact journals and the development of sophisticated tissue-engineering platforms suggest robust extramural funding and interdisciplinary collaborations across reproductive biology, pharmacology, and biomedical engineering. Laboratory & Facilities Dr. Burkin directs a laboratory equipped for integrative reproductive sciences, integrating cell-culture suites, biomechanical stretch systems, mass-spectrometry proteomics, and 3-D bioprinting capabilities to create and validate synthetic myometrial constructs.

• Cardiac Physiology
• Vascular Biology
• Autonomic Nervous System
• +۳ مورد دیگر

Nathan Grainger serves as a Research Assistant Professor in the Department of Physiology and Cell Biology at the University of Nevada, Reno, where his laboratory investigates fundamental mechanisms of pacemaker function in cardiac and urinary systems. His academic credentials include a B.Sc. in Neuroscience from the University of Manchester, United Kingdom, and a Ph.D. in Cellular and Molecular Pharmacology and Physiology from the University of Nevada, Reno. Dr. Grainger's primary research explores the autonomic regulation of sinoatrial node vasculature, energy metabolism in pacemaker cells, and pathophysiological mechanisms in heart failure. His work bridges cardiac electrophysiology and vascular biology, with significant focus on microvascular rarefaction, mitochondrial-sarcoplasmic reticulum interactions, and regional heterogeneity in nodal tissue. Additionally, he investigates peristaltic pacemaker mechanisms in the renal pelvis, examining ion channel dynamics and interstitial cell function. Analysis of his 15 most recent publications reveals a cohesive research trajectory centered on pacemaker dysfunction across organ systems. His cardiac studies predominantly address sinoatrial node vulnerability in heart failure (including HFpEF), while urological work emphasizes Ca 2+ -activated chloride channels and T-type calcium channels in urinary tract pacemaking. This dual focus demonstrates how cellular energy regulation and vascular control mechanisms underlie rhythmicity in both heart and urinary systems. Dr. Grainger leads an active research laboratory utilizing advanced techniques including vibratome sectioning for live imaging of intact pacemaker regions, molecular channel analysis, and metabolic studies. His team develops innovative approaches to isolate and characterize pacemaker tissues while investigating translational implications for heart failure and urinary motility disorders.

• Atherosclerosis regression mechanisms
• Cardiovascular pharmacology
• Diabetes macrovascular complications
• +۴ مورد دیگر

Professor Orina Belton is a distinguished academic at University College Dublin (UCD), where she serves as Professor of Pharmacology in the School of Biomolecular and Biomedical Science. She has held this position since 2018, following progressive academic appointments at UCD including Associate Professor (2016-2018), Senior Lecturer (2014-2016), and Lecturer (2007-2013) in Pharmacology. Her research is conducted through the Conway Institute at UCD's Belfield campus in Dublin 4. Dr. Belton's educational background includes a BSc from NUI Galway and a PhD from University College Dublin. Her academic journey began with postgraduate studies at the Royal College of Surgeons in Ireland (RCSI) from 1995-1999, followed by postdoctoral research at RCSI from 1999-2003. Professor Belton's research program focuses on two primary areas of cardiovascular disease. Her main research interest investigates the fundamental mechanisms governing atherosclerosis regression, utilizing a novel model involving conjugated linoleic acid (CLA) in apoE knockout mice. She employs comprehensive "omic" approaches to identify key genes and pathways involved in plaque regression. Her secondary research area examines macrovascular complications of diabetes, particularly how hypoglycemic drugs affect cardiovascular disease progression in type 2 diabetes patients. This work combines clinical data with molecular analysis of patient plaques and human macrophages. Analysis of Professor Belton's recent publications reveals a strong focus on inflammation resolution in cardiovascular disease, with particular emphasis on macrophage biology, microRNA regulation, and novel therapeutic approaches for atherosclerosis. Her work demonstrates increasing sophistication in molecular techniques, moving from phenotypic observations to network analysis and identification of central regulatory genes. The research bridges basic science with clinical applications, often utilizing both murine models and human tissue samples to validate findings. SMMS Teacher of the Year Award (2015) SMMS Teacher of the Year Award (2014) SMMS Teacher of the Year Award (2011) Professor Belton actively supervises PhD students and has coordinated numerous advanced pharmacology modules including Research Skills, Research Techniques, Advanced Cardiovascular Pharmacology, and Drug Action in Body Systems. Her research has been supported by multiple funding agencies including Science Foundation Ireland, Enterprise Ireland, Health Research Board, European Federation for the Study of Diabetes, and Wellcome Trust. Current and past grants include work on macrophage accumulation in adipose tissue and the Functional Food Centre project. Her laboratory work centers on mechanisms of atherosclerosis regression, with particular focus on how conjugated linoleic acid modulates monocyte/macrophage function. The research team employs a range of techniques from in vivo models to cellular and molecular analysis, including proteomics, RNA-seq, and functional assays examining monocyte-endothelial interactions, integrin regulation, adhesion, migration, and foam cell formation.

• Inflammatory bowel disease
• Eosinophilic esophagitis
• Fibroblast biology
• +۴ مورد دیگر

Dr Mario Manresa is an Assistant Professor (Ad Astra Fellow) in the School of Biomolecular and Biomedical Science at University College Dublin , working from the Conway Institute. He also served as Principal Investigator in the UCD School of Medicine (2022) and held post-doctoral positions at UC San Diego and Harvard Medical School. His research programme dissects how intestinal fibroblasts transition from homeostatic to inflammatory phenotypes and how these cells dialog with innate immune cells in chronic inflammatory disorders such as inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE). Education & Training PhD – University College Dublin Post-doctoral Fellowship – University of California San Diego, Pediatrics (2018–2021) Post-doctoral Fellowship – Harvard Medical School, Brigham and Women’s Hospital, Pathology (2017–2018) Post-doctoral Fellowship – University College Dublin, Medicine (2016–2017) Research Interests Dr Manresa’s laboratory employs primary human cell culture, co-culture systems, flow cytometry and transcriptomics to understand: molecular drivers (TNF-superfamily cytokines such as TWEAK and LIGHT) that switch fibroblasts toward pathogenic phenotypes; micro-environmental modulators (hypoxia, extracellular matrix composition) shaping fibroblast behaviour; therapeutic restoration of WNT pathway homeostasis to resolve inflammation; interactions between inflammatory fibroblasts and monocytes/macrophages that perpetuate mucosal inflammation. Grant Support & Collaborations UCD Conway Institute Director’s Strategic Award – Ad Astra & Emerging Investigators (2022–2024) Enterprise Ireland / UCD Project Grant – pancreatic cancer-on-chip model of immune cell infiltration (2023–2025) Teaching & Mentoring He coordinates two undergraduate modules—“Cell Signalling” and “Molecular Basis of Disease”—and currently supervises PhD theses, having mentored post-doctoral researcher Carlos Matellan Martin. Professional Service Dr Manresa serves as a peer reviewer for Digestive Diseases Week and is multilingual (English, Spanish, Italian), facilitating international collaboration.

• Neuroscience
• Synaptic Transmission
• Synaptic Plasticity
• +۴ مورد دیگر

Professor John O'Connor is a leading academic in the School of Biomolecular and Biomedical Science at University College Dublin , with a distinguished career spanning over three decades. His research focuses on synaptic transmission and plasticity in the central nervous system, neuroimmunology , and smooth muscle physiology , particularly in human uterine tissue. Academic Leadership : Served as Head of Teaching & Learning (2019-2023) and Associate Dean for Widening Participation (2012-2019). Teaching Philosophy : Advocates for blended and interactive teaching with humor and engagement, coordinating modules like Higher Cortical Function and Synaptic Plasticity since 2020. Research Highlights : Neuroprotection : Investigates prolyl hydroxylase domain inhibitors (PHDIs) and their role in stroke therapy , Parkinson's disease , and amyotrophic lateral sclerosis . Demonstrated PHDI-mediated synaptic transmission recovery post-hypoxia and HIF-independent mechanisms in neuroprotection. Neuroimmunology : Pioneered studies on tumor necrosis factor-alpha (TNF-α) modulation of long-term potentiation (LTP) during hypoxia and its implications for memory formation and neuroinflammatory disorders . Fast Cyclic Voltammetry : Advanced real-time monitoring of dopamine release in striatum and nucleus accumbens , exploring interactions with MDMA , nicotine , and dopamine D1 receptor ligands . Human Myometrium Studies : Collaborates with Coombe Women's Hospital on ergometrine mechanisms , prostaglandin effects , and antioxidant protection against toxicant-induced contractility inhibition. Scientific Recognition : Recipient of the Conway Silver Medal (2010), Teaching Excellence Award (2016), and Conway Fellow (2007). Active reviewer for journals like Neuropharmacology and Scientific Reports .

Michael E. Giangمشاهده پروفایل

استادیار

• Pediatric Critical Care
• ECMO Complications
• Pulmonary Vascular Physiology
• +۳ مورد دیگر

Michael E. Giang, MD serves as Assistant Professor in the Department of Pediatrics within the Pediatric Intensive Care Division at Loma Linda University School of Medicine. His clinical and research focus centers on physiological complications in critically ill pediatric patients requiring advanced life support. Research Focus Dr. Giang's work investigates ECMO-associated complications including intra-abdominal hypertension and abdominal compartment syndrome, alongside pulmonary vascular responses to chronic hypoxia using translational ovine models. His research bridges clinical observations with mechanistic studies of vascular contractility and organ dysfunction. Publication Trends Analysis of his publications reveals consistent investigation of mechanical circulatory support complications (2019) and foundational work on hypoxia-induced vascular changes (2014-2016). This demonstrates an evolving trajectory from basic physiological mechanisms toward clinical ECMO complications in pediatric critical care. Research Support Principal Investigator: Effects of extracorporeal membrane oxygenation on intra-abdominal pressure and acute kidney injury (LLU Dept. of Pediatrics, 10/2020-10/2021, Completed)

Derek Kendigمشاهده پروفایل

دانشیار

• Physiology
• Nutrition
• Gastrointestinal Motility
• +۵ مورد دیگر

Derek Kendig is an Associate Professor in the Department of Biology at Loyola University Maryland. His research focuses on gastrointestinal (GI) physiology, particularly the mechanisms by which nutrients influence GI motility patterns and smooth muscle function. He employs techniques like video recording, computer analysis, and spatiotemporal mapping to study nutrient effects on motility in the stomach, small intestine, and colon. Specialization: Gastrointestinal Physiology and Nutrition Email: dmkendig@loyola.edu Dr. Kendig's work examines intracellular signaling pathways in GI smooth muscle and hypothesizes that nutrients activate mucosal receptors, which communicate with smooth muscle via the enteric nervous system. His methods are also applicable to studying smooth muscle in the urinary bladder and blood vessels. Scientific awards or educational details are not mentioned in the provided text. Recent publications highlight his research on nutrient receptors (e.g., umami), signaling molecules like hydrogen sulfide, and the role of kinases in GI motility. His work spans both tissue-level contractility and organ-level motility patterns, emphasizing the interplay between luminal nutrients and physiological responses.

Daniel Beardمشاهده پروفایل

استاد

• Systems Physiology
• Computational Biology
• Cardiovascular Modeling
• +۳ مورد دیگر

Daniel Beard, Ph.D. is a Professor in the Department of Molecular & Integrative Biology at the University of Michigan Medical School. His research focuses on systems engineering approaches to physiological systems, with particular emphasis on metabolic systems, cardiovascular mechanics, blood-flow regulation, and renal solute transport. His research interests span Systems Physiology , Computational Biology , and Quantitative Systems Pharmacology , with current work heavily concentrated on heart failure mechanisms, mitochondrial metabolism, and digital twin applications. His laboratory develops Physiology-driven computational models of cardiac function Machine learning frameworks for phenotyping heart failure Multiscale models of metabolic regulation Digital twin technologies for personalized cardiac care Analysis of his 15 most recent publications (2024-2025) reveals a dominant focus on heart failure with preserved ejection fraction (HFpEF), appearing in 7 of the 15 articles. Key thematic clusters include: Computational modeling of cardiac energetics and metabolism (12 articles) Digital twin development for clinical prediction (5 articles) Ion signaling in vascular regulation (4 articles) Machine learning applications in cardiovascular diagnostics (4 articles) His work demonstrates strong integration of theoretical modeling with experimental validation. No scientific awards are explicitly mentioned in the provided materials. Dr. Beard maintains an active research program with significant NIH funding implied through his publication topics, though specific grants are not detailed. His laboratory appears to train graduate students within the Molecular & Integrative Biology program, though no specific advisees are named in the materials. He leads a research team focused on computational physiology and maintains an active lab website.

• Molecular Genetics
• DNA Repair Mechanisms
• Vascular Biology
• +۳ مورد دیگر

Ingrid van der Pluijm is an Associate Professor at Erasmus MC , affiliated with the Department of Molecular Genetics. Her research spans DNA repair mechanisms, vascular biology, cardiovascular diseases, and aging, with recent work focusing on dietary restriction, cardiac fibulin-4, and stem cell-derived cardiomyocytes. Research Interests include DNA damage response in progeroid models, vascular smooth muscle cell dysfunction, and molecular pathways underlying heart failure. Her work intersects molecular genetics and translational medicine, utilizing mouse models to study aging-related pathologies. Scientific Contributions highlight her role in 66 research outputs, including studies on: Modulating the cGAS-STING pathway in vascular aging Cardiac fibulin-4 as a protective agent in heart failure Stem cell-derived cardiomyocyte differentiation protocols Social frailty indices in aging mice Current collaborations involve institutions like the University of Minnesota, C57BL/6 mouse models, and interdisciplinary teams in molecular imaging and cell biology.

• Bioinformatics
• Computational Biology
• Translational Bioinformatics
• +۴ مورد دیگر

Tong Zhou is an Associate Professor at the Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine. His research focuses on bioinformatics and computational biology, particularly translational bioinformatics and computational RNA biology. B.S., Biomedical Engineering, Southeast University, China M.S., Bioinformatics, Southeast University, China Ph.D., Bioinformatics, Southeast University, China Key research areas include: Development of computational tools for omics data analysis Investigation of noncanonical small noncoding RNAs (tsRNAs, rsRNAs) Environmental stressor/diet-induced RNA code and epigenetic inheritance RNA modifications and regulatory mechanisms Recent publications highlight his work on small RNAs in disease contexts (2022-2020), including SARS-CoV-2 inflammation, cardiac hypertrophy, and biomarkers in cancer/pulmonary diseases. His methodological contributions include AQUARIUM and PANDORA-seq algorithms for RNA analysis.

Miao Zhangمشاهده پروفایل

دانشیار

• Ion Channels
• Structural Biology
• Electrophysiology
• +۵ مورد دیگر

Dr. Miao Zhang is an Associate Professor in the School of Pharmacy at Chapman University, specializing in ion channels, structural biology, electrophysiology, drug discovery, and movement disorders. His research focuses on understanding the structure and function of small-conductance Ca 2+ -activated K + (SK) channels and developing structure-aided drug discovery approaches for neurological and cardiovascular diseases. Hebei Medical University, Bachelor of Science Hebei Medical University, Master of Science Kyoto University, Ph.D. in Pharmaceutical Sciences (2007) Dr. Zhang's research program utilizes structural biology techniques to investigate ion channels as potential drug targets. His laboratory focuses on two primary research areas: (1) structure-aided drug discovery targeting SK2 channels for movement disorders including ataxia and essential tremor; and (2) structure-aided drug discovery targeting SK3 channels for vascular diseases. His work bridges molecular structure, channel function, and therapeutic applications, with particular emphasis on understanding how mutations and pharmacological modulators affect channel behavior. Analysis of Dr. Zhang's recent publications reveals a consistent focus on the structural determinants of potassium channel function, particularly the role of specific domains like the HA/HB helices and S4-S5 linker in channel gating and modulation. His research demonstrates how subtle structural changes can dramatically alter channel properties and how these insights can be leveraged for developing subtype-selective therapeutics. The publications span multiple disciplines including molecular pharmacology, structural biology, and disease modeling. Dr. Zhang is an active member of several professional organizations including the Biophysical Society, Society for Neuroscience, and American Heart Association, reflecting the interdisciplinary nature of his research. With over 20 peer-reviewed publications in high-impact journals such as Nature Chemical Biology, Science Advances, PNAS, and Nature Communications, Dr. Zhang has established himself as a significant contributor to the field of ion channel research and drug discovery. His work has been cited extensively, demonstrating its impact on understanding channel structure-function relationships and therapeutic targeting.

• Cardiovascular Physiology
• Hypertension
• Cell Signaling
• +۳ مورد دیگر

Madhu Anand-Srivastava serves as an Honorary Professor within the Department of Pharmacology and Physiology at the Faculty of Medicine, University of Montreal. Her research program investigates molecular mechanisms underlying cardiovascular pathologies, with particular emphasis on hypertension, vascular dysfunction, and diabetes through the lens of G protein signaling and oxidative stress pathways. Educational background: Ph.D. in Physiology from the University of Manitoba (1978) M.Sc. in Medical Biochemistry from Delhi University (1972) Her laboratory employs advanced molecular techniques including cell culture, Western blotting, gene knockdown via antisense/siRNA, and transmembrane signaling analysis to study vascular smooth muscle cell behavior. Current research focuses on natriuretic peptide receptor-C functions, angiotensin II signaling cascades, and ROS-mediated pathways in hypertension models. Key methodologies involve blood pressure measurement in genetic hypertensive rat strains and quantification of cellular proliferation/hypertrophy through isotopic incorporation assays. Analysis of her 2016-2018 publications reveals consistent investigation into Giα/Gqα protein dysregulation in vascular pathology. Her work demonstrates how natriuretic peptides and natural compounds like resveratrol attenuate pathological vascular remodeling through G protein modulation and oxidative stress reduction, with strong translational relevance for hypertension therapeutics. No specific scientific awards were documented in the source material. Dr. Anand-Srivastava actively mentors graduate researchers in cardiovascular pharmacology and maintains collaborative projects within the University Research Group on Medicine (GRUM). Her laboratory receives competitive grant funding supporting mechanistic studies on G protein-coupled receptor signaling in cardiovascular disease models. Current work continues to explore therapeutic targeting of oxidative stress pathways in hypertension.

• Atherosclerosis
• Cardiovascular Disease
• Macrophage Biology
• +۳ مورد دیگر

Professor Erik Biessen is a cardiovascular research scientist affiliated with the Institute for Molecular Cardiovascular Research (IMCAR). His work focuses on molecular mechanisms underlying atherosclerosis, macrophage biology, lipid metabolism, and inflammation. He leads studies on proteoglycan signaling, chemokine networks, and metabolic reprogramming in cardiovascular pathologies. Key Research Areas Atherosclerosis mechanisms and plaque vulnerability Macrophage heterogeneity in cardiovascular disease Lipidomics and uremic toxin interactions Role of microRNAs and metabolic networks Recent Article Trends Studies on cathepsin D inhibition in liver lipidomics (2025) MicroRNA-26b's protective role in MASH (2025) Investigations into glutamine metabolism's impact on plaque inflammation (2024) Chemokine CCL18's role in T-cell infiltration (2024)

• Critical Care Medicine
• Pulmonary Medicine
• Respiratory Medicine
• +۳ مورد دیگر

Dr. Karl A. Sanders is a Clinical Associate Professor of Medicine in the Department of Internal Medicine at the University of Utah School of Medicine, serving as Pulmonary and Critical Care Medicine Fellowship Training Program Director within the Division of Respiratory, Critical Care and Occupational Pulmonary Medicine. His clinical practice is exclusively based at the George E. Wahlen VA Medical Center where he manages critically ill patients in the medical ICU and outpatient pulmonary clinics. Dr. Sanders' educational background includes: Medical Degree (M.D.): University of Kansas Undergraduate Degree (B.A. in History): University of Kansas Residency in Internal Medicine: University of Minnesota Hospitals Fellowship in Pulmonary Medicine: University of Utah School of Medicine His research focuses on molecular mechanisms in pulmonary diseases, particularly oxidative stress pathways, mitochondrial dysfunction, and immune responses. Key investigations include RAGE signaling in lung injury and cancer metastasis, NADPH oxidase in oxygen sensing, and sex hormone effects on airway inflammation. His work bridges basic science with clinical applications for conditions like COPD, asthma, and pulmonary hypertension. Analysis of his publication record reveals consistent exploration of receptor-mediated pathways (RAGE, NOX4) in pulmonary pathophysiology, with recent emphasis on immunometabolism and hormonal influences. His collaborative studies frequently examine mitochondrial adaptations to environmental stressors like cigarette smoke and hypoxia. As Fellowship Training Program Director, Dr. Sanders oversees comprehensive education for future pulmonary/critical care specialists, actively mentoring medical students, residents, and fellows in clinical pulmonary medicine. His leadership coordinates the division's mission to develop clinicians, investigators, and educators in this specialty.

• Cardiology
• Heart Disease
• Vasoactive Substances
• +۸ مورد دیگر

Adel Schwertani is a Professor in the Department of Medicine, Faculty of Medicine and Health Sciences at McGill University, and a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) at the Glen site. He is affiliated with the Cardiovascular Health Across the Lifespan Program within the Centre for Translational Biology and works in the Department of Medicine, Division of Cardiology at the MUHC. Dr. Schwertani's research focuses on the role of vasoactive and structural proteins in the pathogenesis of cardiovascular diseases including atherosclerosis, myocardial infarction, aortic valve disease, and pulmonary hypertension. Along with his collaborators, he investigates the role of stem cells in cardiac regeneration and personalized drug testing. His laboratory recently identified a new mediator in the pathogenesis of thrombosis and is working with national and international collaborators to develop new therapeutic approaches for pulmonary emboli and deep vein thrombosis. His publication record demonstrates consistent contributions to understanding the molecular mechanisms of cardiovascular disease, particularly in the areas of aortic valve stenosis, lipoprotein(a) effects on cardiovascular tissues, and novel approaches to cardiac repair. His work bridges basic science with clinical applications, focusing on translating laboratory findings into potential therapeutic strategies for cardiovascular conditions. Dr. Schwertani actively collaborates with researchers across multiple institutions, as evidenced by his co-authorship on systematic reviews and meta-analyses of preclinical trials in cardiac regeneration. His research program appears to be well-integrated within the cardiovascular research community at McGill University and the RI-MUHC.