Kay Severin is a full professor at the Laboratory of Supramolecular Chemistry (LCS) within École Polytechnique Fédérale de Lausanne (EPFL) , Switzerland. His research focuses on the design and reactivity of metal-ligand assemblies, including coordination cages, metalloligands, and supramolecular receptors. He has pioneered the use of metalloligands for constructing heterometallic architectures and developed systems for anion extraction and stimuli-responsive hydrogels. Key funder: Swiss National Science Foundation (FNS) Collaborative work with Rosario Scopelliti and Farzaneh Fadaei Tirani Research Interests: Severin's work spans supramolecular chemistry, organometallic synthesis, and functional materials. Recent projects include: Dynamic palladium-based hydrogels with anion-responsive crosslinks Gold(I)-driven nano-onion structures via π-stacking Triazene-derived ligands for Sandmeyer-type reactions Metalloligand assembly of Fe/Pd/Au heterotrimetallic cages Publication Trends: Over 300 publications since 1994, with recent emphasis on: Coordination-driven self-assembly (2024: 6 articles) Triazene and diazoolefin reactivity (2025: 4 articles) Metal-ligand interactions in nanogels and vesicles (2024-2025: 3 articles) Environmental applications in anion extraction (2025: 1 article)
Henry Liang, Ph.D., is a Professor in the Department of Cell Physiology and Molecular Biophysics at Texas Tech University Health Sciences Center (TTUHSC), with adjunct appointments in Chemical Engineering and Chemistry at Texas Tech University. His lab focuses on bridging biology with synthetic systems through membrane biophysics and bioengineering. Research Interests: Dr. Liang's work spans membrane protein reconstitution, nanodisc technology, antimicrobial nanoparticles, blood-brain barrier targeting, and immunotherapy platforms. Key areas include: Design of synthetic proteomembranes for protein function studies Development of environmentally responsive nanoantibiotics Nanoparticle-based theranostic systems for cancer Light-driven energy transduction in biohybrid materials Publication Trends: His 15 most recent articles (2011-2023) demonstrate consistent focus on nanotechnology solutions for biomedical challenges, with evolving emphasis on antimicrobial nanostructures (35%), membrane protein platforms (30%), cancer nanomedicine (20%), and sustainable nanomaterials (15%). Methodological strengths include polymer synthesis, X-ray scattering, and biomimetic system design. Training: The Liang Lab actively recruits graduate students and postdoctoral researchers for projects in membrane biophysics and bioengineering. Current research infrastructure includes capabilities for synchrotron small-angle X-ray scattering, molecular dynamics simulations, and nanomaterial characterization.
Ying Ge is a Professor at the University of Wisconsin–Madison, jointly appointed in the Department of Cell and Regenerative Biology and the Department of Chemistry. Her research integrates chemistry, biology, and medicine, focusing on advanced mass spectrometry-based proteomic and metabolomic technologies to address cardiovascular diseases. Education: B.S., Peking University (1997) Ph.D., Cornell University (2002) Ying Ge's work centers on developing ultra high-resolution mass spectrometry platforms for top-down proteomics and metabolomics, applied to systems biology studies of heart failure and regenerative medicine. Key projects include myofilament protein modification mapping, stem cell therapy evaluation, and biomarker discovery for cardiac conditions. The 15 most recent articles highlight her lab's methodological innovations (e.g., photocleavable surfactants, native mass spectrometry) and biological discoveries in AMPK structural heterogeneity, RBM20-mediated cardiotoxicity, and sarcomere-metabolism cross-talk during regeneration. These publications span proteomics, metabolomics, structural biology, and clinical applications.
Dr. Sander J. Wezenberg is an Associate Professor at the Leiden Institute of Chemistry, Leiden University, where he leads an independent research group focused on developing stimuli-responsive molecular receptors and self-assembling materials. He was appointed Assistant Professor at the University of Groningen in 2017 and moved to Leiden University in 2019 to establish his research group, where he was promoted to Associate Professor in 2022. Dr. Wezenberg's educational background includes: Master's degree in Chemistry at the University of Nijmegen, conducting research in Prof. Roeland Nolte's group PhD in Supramolecular Chemistry at the Institute of Chemical Research of Catalonia (ICIQ) under Prof. Arjan Kleij (2011) Postdoctoral fellow with Prof. François Diederich at ETH Zurich Postdoctoral work with Prof. Ben Feringa at the University of Groningen His research focuses on using interdisciplinary approaches combining synthetic organic chemistry, supramolecular chemistry, and photochemistry to develop systems that can study and manipulate biological processes. Key research areas include: Photodynamic control of anion binding and lipid bilayer membrane transport Creation of polymeric and self-assembled materials with switchable functions Development of new diagnostic tools and therapeutic agents to improve human health Dr. Wezenberg's recent publications demonstrate strong trends in photoresponsive molecular systems for controlling anion transport and membrane properties. His work bridges chemistry, materials science, and biological applications, with particular emphasis on light-switchable molecular receptors and their applications in biological systems. Scientific awards and recognition: ERC Starting Grant (2018) Veni Grant from NWO (2014) Vidi Grant from NWO (2018) Member of the Young Academy of Europe (2020) Dr. Wezenberg actively mentors PhD and Master's students, with current advisees including Nol Duindam, Sabine Langens, Sofiia Emashova, Lin Xu, Dimitris Piperoudis, and Josien de Graaf. His research is supported by multiple funding sources including Leiden University, the European Research Council, the Dutch Research Council, and the China Scholarship Council. The Wezenberg Research Group is based at the Gorlaeus Laboratories in the new Gorlaeus Building at Leiden University, where they maintain a highly collaborative research environment focused on molecular switches, anion recognition, and dynamic supramolecular systems.
Xenophon Papademetris is a Professor of Biomedical Informatics & Data Science and Radiology & Biomedical Imaging at Yale School of Medicine. He serves as Associate Director of Biomedical Imaging Data Sciences at Yale Biomedical Imaging Institute and directs the Medical Software and Medical Artificial Intelligence Certificate Program. PhD in Electrical and Information Sciences from Yale University (2000) BA from Cambridge University (1994) Postdoctoral Fellowship at Yale University (2002) His research focuses on medical image analysis, machine learning, and biomedical software development. He has developed tools like BioImage Suite Web and contributed to standards committees at the Association for the Advancement of Medical Instrumentation (AAMI). His work spans modalities including MRI, CT, PET, and optical imaging. Recent publications emphasize neuroimaging analysis, explainable AI in healthcare, and multimodal data integration across species. He leads NIH-funded research under the BRAIN Initiative (R24 MH114805) and has authored a textbook on Medical Software published by Cambridge University Press. IEEE Senior Member Yale Brown-Coxe Postdoctoral Fellowship Harding Bliss Prize for Excellence in Engineering He directs the BioImage Suite Project, creating web-based image analysis tools using JavaScript and WebAssembly. His teaching includes both academic courses and a Coursera program on Medical Software with over 14,000 enrollments.
Professor Charlotte Deane is a leading academic in structural bioinformatics, holding the position of Professor at the University of Oxford's Department of Statistics and Executive Chair of the Engineering and Physical Sciences Research Council (EPSRC). She leads the Oxford Protein Informatics Group (OPIG), focusing on protein structure prediction, immunoinformatics, and AI-driven drug discovery. Her research integrates computational methods with biological insights, developing tools widely used in academia and industry. Prior roles include Head of the Department of Statistics, Deputy Head of the Mathematical, Physical and Life Sciences (MPLS) Division at Oxford, and Chief Scientist of Biologics AI at Exscientia. During the COVID-19 pandemic, she served on SAGE and as UKRI's COVID-19 Response Director. In 2022, she was awarded an MBE for her contributions to pandemic research. Her research group's work spans antibody design, T-cell receptor analysis, and small molecule discovery, with a focus on open-source software development. Current projects include advancing AI methods for protein structure prediction and therapeutic antibody engineering. Recent publications highlight innovations in computational drug design, antibody developability, and machine learning applications in structural biology.
Nicolas Thomä is a Full Professor and head of the Thomä Lab at the École Polytechnique Fédérale de Lausanne (EPFL), where he holds the Paternot Chair in Cancer Research. He is affiliated with the School of Life Sciences (SV) and the Institute of Chemical and Biological Technology (ISREC), leading the UPTHOMAE research unit. His work bridges structural biology, chemical biology, and cancer research, with a focus on transcriptional regulation and targeted protein degradation. His research interests center on chromatin biology and the molecular mechanisms by which transcription factors access gene promoters within chromatin. He investigates how multi-protein complexes regulate gene expression, particularly focusing on the role of E3 ubiquitin ligases and molecular glues in targeted protein degradation. His lab combines structural techniques (including cryo-EM), biochemical assays, and functional genomics to unravel how small molecules can rewire protein interactions and induce degradation of disease-relevant proteins, especially transcription factors involved in cancer. The recent publications of his lab demonstrate a strong trajectory in understanding the structural basis of transcription factor binding to nucleosomes (e.g., OCT4-SOX2, MYC-MAX, CLOCK-BMAL1) and the mechanism of action of molecular glues like thalidomide. These studies highlight a shift toward therapeutic innovation through chemical biology, aiming to develop novel strategies for targeting 'undruggable' proteins in human diseases. Scientific Awards No specific awards listed in the provided text. Advising and Grants Thomä actively supervises a team of PhD students and postdoctoral researchers, including David Domjan, Laurin Tim Kanis, Alessandro Minafra, and Pierre Alexander Miranda Herrera. His lab is supported by institutional funding from EPFL and likely external grants related to cancer research, structural biology, and chemical biology, though specific grants are not mentioned. The lab’s interdisciplinary approach suggests collaboration with pharmaceutical and biotech partners. Labs and Teams The Thomä Lab, based at EPFL’s SV building, includes a multidisciplinary team of scientists, technical specialists, and administrative support. Key members include Fiona Bello (Technical Specialist), Regina Baur, Alexandra Bendel, Manuel Carminati, and others. The lab is structured around two main research pillars: Transcription Factors in Chromatin Biology and Ubiquitin Biology and Molecular Glues, reflecting its dual focus on fundamental mechanisms and therapeutic applications.
Chiu Ping Cheng is a Professor in the Department of Biology at the University of Minnesota, USA, specializing in Molecular Biology and Plant-Microbe Interactions . With over two decades of research on Ralstonia solanacearum and its interactions with solanaceous crops, Dr. Cheng has pioneered studies on plant defense mechanisms against bacterial wilt, regulatory gene functions, and biocontrol agent applications. Current research: Plant-pathogen interactions Special techniques: Genomic screening, bacteriophage-derived proteins Key pathogens: Ralstonia solanacearum, Pectobacterium carotovorum His recent publications (2024) explore tomato cultivar resistance variation , NADPH oxidase-effector interactions , and phenylpropanoid metabolism in wild mungbean . Though no formal scientific awards are listed, his work has been featured in leading journals like Plant Cell & Environment and New Phytologist . Dr. Cheng operates from the Life Science Building R942 laboratory.
Tyler Johnson, PhD, is an Associate Professor in the Department of Natural Sciences and Mathematics at Dominican University of California's School of Health and Natural Sciences. His expertise lies in Natural Products Chemistry , Bioorganic Chemistry , and Medicinal Chemistry , with a focus on biomedical applications. Johnson's research emphasizes discovering therapeutic lead compounds and molecular probes from marine and terrestrial natural products. His research team investigates chemotypes like mycothiazole , zampanolide , fijianolide , and latrunculin from Indo-Pacific marine sponges. These compounds exhibit potent cytotoxicity (IC50 1~5 nM) against cancer cell lines through mechanisms including microfilament disruption , mitochondrial complex I inhibition , and microtubule stabilization . Current work explores mycothiazole as a molecular probe for mitochondrial aging. Key publications span 2024-2002, covering topics from sponge-derived anticancer agents to inflammation modulation and environmental toxicology. Johnson's laboratory engages in large-scale natural product isolation, spectroscopic validation, and semi-synthetic medicinal chemistry to optimize therapeutic leads. His work integrates undergraduate and graduate students into interdisciplinary biomedical research.
Prof. Stephan J. Sigrist is a Full Professor of Genetics at the Institute of Biology, Free University of Berlin. His lab focuses on synaptic active zone architecture, neuroplasticity, and aging-related neurodegeneration. He leads the Collaborative Research Center 958 on Membrane Scaffolding and co-directs NeuroCure, a DFG Cluster of Excellence at Charité. Education: PhD in Molecular Genetics (1997) and Habilitation (2005) from the University of Göttingen. Positions: Einstein Professor (2014–present), Spokesperson CRC 958 (2012–present), and Co-Director NeuroCure (2009–present). Research explores presynaptic mechanisms using Drosophila and mouse models, combined with STED microscopy. Key contributions include discoveries of Bruchpilot's role in active zones and spermidine's protective effects against age-related synapse decline. Grants: Over €6 million in funding, including DFG CRCs, Einstein Foundation, and ERC Advanced Grant (2025). Awards: Einstein Professorship, Best Habilitation Award, EMBO/HFSP Fellowships. Collaborations span structural biology (e.g., Stefan Hell), neurophysiology (David DiGregorio), and aging research (Frank Madeo).
Maria Chikina is an Assistant Professor at the University of Pittsburgh School of Medicine's Department of Computational and Systems Biology. She holds a PhD in Molecular Biology from Princeton University. Her research focuses on developing computational methods to analyze large-scale genomic datasets, bridging statistical rigor with biological insights to overcome experimental biases. Key research areas include latent variable modeling (e.g., PLIER, CellCODE), interpretable neural networks for sequence-to-function modeling, evolutionary rate analysis (RERconverge), and applications in tumor immunology, exercise genomics, and infectious disease (e.g., SARS-CoV-2). Her lab has developed tools like InstaPrism, NIFA, and L0 segmentation for data-driven biological discovery. Her work spans collaborations with institutions like UPMC (on tumor microenvironment) and the Molecular Transducers of Physical Activity Consortium (MoTraPAC). Notable projects include analyzing convergent evolution in marine mammals and subterranean species, and developing epigenetic biomarkers for disease states through the ECHO program. Lab members include PhD students (Rezwan Hosseini, Tugrul Balci) and postdocs (Tina Subic, Anish Sevekari). Past students Wynn Meyer now leads a group at Lehigh University. Her group emphasizes open-source tools (GitHub repository ChikinaLab) and interdisciplinary approaches to systems biology challenges.
Sarah Lummis is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on understanding the structure-function relationships of Cys-loop ligand-gated ion channels (pLGICs), which are critical for neurotransmission and targets for pharmaceuticals. Her work addresses how structural features of these receptors influence their function and drug interactions. Research interests include ion channel biology, molecular pharmacology, and structural biology. Key publications investigate residues affecting receptor activity in 5-HT3 receptors, glycine receptors, and the prokaryotic channel ELIC. Her studies contribute to drug development for neurological disorders like epilepsy and Alzheimer's disease. Contact: sl120sec@bioc.cam.ac.uk | Group accepts interns, students, and researchers. Located at the Hopkins Building, Downing Site, Cambridge.
Maartje Bastings is an Associate Professor at the École Polytechnique Fédérale de Lausanne (EPFL) , leading the Programmable Biomaterials Laboratory (PBL) within the School of Engineering (STI) . She holds additional affiliations with the Institute of Materials (IMX) , IBI-STI (Bioengineering), and supervises doctoral programs in Biotechnology and Biological Engineering ( EDBB-GE ) and Materials Science and Engineering ( EDMX-GE ). Her research focuses on DNA-based supramolecular materials engineered to achieve dynamic reciprocity —a two-way interaction between synthetic materials and biological systems. By leveraging DNA as a programmable scaffold, she investigates structural mechanics, valency control, and geometric constraints governing self-assembly and cell communication at bio-interfaces. Key applications include immune system modulation, diagnostics , and vaccine development . Analysis of her 15 most recent publications reveals a focus on multivalent interactions for T-cell activation, spatial patterning in immune signaling, and engineered coatings for DNA origami stability. Subfields span T cell receptor engineering , nanoscale protein dynamics , stimuli-responsive biomaterials , and bio-inspired therapeutic design . PhD Students: Chen Yuduo Hendrickx Pauline Bart M. Kononenko Artem Li Shujie Lou Yameng Meyer Pitt Narita Minako Rousseau Benjamin Bila Hale Caroprese Vincenzo Comberlato Alice Kurisinkal Eva Eugene Paloja Kaltrina Rodríguez Franco Hugo José Tekin Cem Wong Siu Ho Contact: maartje.bastings@epfl.ch
Fabian Pfrengle is a full Professor of Organic Chemistry at the Institute of Organic Chemistry , Department of Natural Sciences and Sustainable Resources , University of Natural Resources and Life Sciences Vienna (BOKU). He previously led research groups at the Max Planck Institute of Colloids and Interfaces (2013-2020) and worked at The Scripps Research Institute (2010-2013). Research Focus: His work bridges carbohydrate chemistry and plant biology , specializing in plant cell wall glycans and glycosyltransferases . He develops synthetic glycan arrays for enzyme characterization and investigates immune response triggering mechanisms in plants through oligosaccharide fragments . His projects include automated polysaccharide synthesis and liposome-based immune tolerance applications. Publication Trends: His 15 most recent articles emphasize chemical synthesis of sugar nucleotides , plant glycan arrays , and enzyme specificity analysis , reflecting his focus on carbohydrate engineering and plant immunity . Key subfields include UDP-sugar derivatization , Xylan structure-function relationships , and Glycosyltransferase profiling . Grants & Projects: Currently leads 5 major projects including Automated Algal Polysaccharide Synthesis (EU-funded, 2023-2028) and Synthetic Glycan Ligands for Plant Immune Receptors (FWF-funded, 2022-2026). His research also explores thrombocyte biology and Rhamnogalacturonan-II fragments with support from FWF and City of Vienna . Community Service: Serves on editorial boards ( Monatshefte für Chemie , 2021-present) and as reviewer for 12 journals including JACS Au , Nature Communications , and Angewandte Chemie . Member of professional societies: Gesellschaft Österreichischer Chemiker (2020), Deutscher Hochschulverband (2019), and Gesellschaft Deutscher Chemiker (2008).
William A. Goddard, III is the Charles and Mary Ferkel Professor of Chemistry, Materials Science, and Applied Physics at the California Institute of Technology. With a career spanning over five decades, he has held positions from Noyes Research Fellow (1964–66) to his current professorship since 2001. His educational background includes a B.S. from UCLA (1960) and a Ph.D. from Caltech (1965). Quantum chemistry and first-principles simulations Multiscale modeling (QM→MD→mesoscale) Catalysis and protein structure prediction Nanotechnology and bionanotechnology Energy storage (batteries, supercapacitors) Recent publications emphasize applications in metal-organic frameworks , electrocatalysis , and space manufacturing , reflecting his interdisciplinary approach. His work on G-protein coupled receptors and Li-S batteries demonstrates methodological innovation through quantum mechanics and machine learning . Horizon Prize , Royal Society of Chemistry Over 1548 total publications (1967–2022) As Director of Caltech's Material and Process Simulation Center , he leads development of software like ReaxFF for reactive dynamics. He teaches Ch 120 ab (Nature of the Chemical Bond) and Ch 121 ab (Atomic-Level Simulations), emphasizing hands-on computational applications for experimentalists and theorists.
