جست‌وجوی استاد و پژوهشگر

Patrick Bradleyمشاهده پروفایل

استادیار

• Human microbiome
• Bioinformatics
• Genomics
• +۴ مورد دیگر

Patrick Bradley is an Assistant Professor of Microbiology at The Ohio State University, affiliated with the College of Arts and Sciences. He is also part of the Infectious Diseases Institute and the Center of Microbiome Science. His research focuses on understanding human microbiota (particularly the gut and oral microbiomes) using computational and experimental approaches. Bradley earned his A.B. from Harvard University (2005), Ph.D. from Princeton University (2012), and completed a postdoctoral fellowship at the University of California, San Francisco (2013–2020). Education: A.B., Harvard University, 2005 Ph.D., Princeton University, 2012 Postdoc, University of California, San Francisco, 2013–2020 His research interests include microbial gene function prediction, gene regulation in adaptive environments, and the role of microbiomes in drug metabolism and disease. Current lab projects involve leveraging natural genetic variation to identify genes influencing microbial colonization, understanding regulatory mechanisms in microbial adaptation, and developing machine learning tools for functional annotation. Recent work highlights the disproportionate impact of genomic misassembly in metagenomic studies and the shared metabolic pathways between hosts and microbes in cancer drug processing. Bradley’s lab actively collaborates on projects such as PanSweep (a tool to detect pangenome contamination) and Phylogenize2 (for phylogeny-corrected gene association analysis). Advising and grants: Bradley mentors PhD students (Christian J. Quiles Pérez, Stephanie Majernik, Nghi Tran, Alexis Young) and has contributed to studies exploring microbiome-modulating therapies. The Bradley Lab is part of interdisciplinary initiatives at Ohio State, emphasizing translational research in microbiome science. Lab activities include developing computational tools for microbiome analysis and maintaining collaborations with institutions like the Center for Microbiome Science. The lab’s work has implications for precision medicine and understanding microbial contributions to human health.

Carsten Korthمشاهده پروفایل

استاد

• Neurodegenerative diseases
• Chronic mental illnesses
• Protein misassembly
• +۴ مورد دیگر

Prof. Dr. Carsten Korth is a faculty member at the Institute of Neuropathology , Heinrich Heine University Düsseldorf. His research focuses on aberrant proteostasis in chronic brain diseases, spanning neurodegenerative disorders (Alzheimer's, Parkinson's) and chronic mental illnesses like schizophrenia. Academic rank: Professor Location: Moorenstraße 5, Düsseldorf Research areas include: Virus-induced proteostasis dysfunction in neurodegenerative diseases Neurobiology of schizophrenia and affective disorders Development of conformation-sensitive diagnostics Translational biomarker discovery Neuronal aging mechanisms Recent publications highlight SARS-CoV-2 neurotropism, herpesvirus-Alzheimer's intersections, and immune gene networks in schizophrenia. Collaborative work spans bioRxiv , PNAS , and Molecular Psychiatry . Education and career milestones: MD thesis (1995), LMU Munich Postdoc, University of California San Francisco (1998-2001) Habilitation in Molecular Neuropathology (2003) Principal Investigator, Heinrich Heine University (since 2002)

• Structural Biology
• Biophysics
• Molecular Biophysics
• +۷ مورد دیگر

Javier Fernández Martínez is an Ikerbasque Research Professor at the Biofisika Institute, a joint research center of the Spanish National Research Council (CSIC) and the University of the Basque Country (EHU), located in Leioa, Spain. He leads the Integrative Structural and Functional Characterization of Macromolecular Assemblies Laboratory, where his work focuses on understanding the architecture and dynamics of large biological complexes. His research lies at the intersection of structural biology, biophysics, and molecular biochemistry. Using integrative approaches that combine experimental and computational techniques, he investigates the structure-function relationships of macromolecular assemblies essential for cellular processes. His work contributes to fundamental understanding in cell biology and has implications for disease mechanisms involving protein misassembly. The laboratory he directs emphasizes interdisciplinary methodologies, including cryo-electron microscopy, X-ray crystallography, and molecular modeling, to resolve complex biomolecular systems. While no specific publications or students are listed in the provided text, his leadership role suggests active involvement in training and collaborative science. Scientific Awards: No awards listed in the provided text. Advising and Grants: As a principal investigator at a major research institute, Dr. Fernández Martínez likely supervises PhD students and postdoctoral researchers and secures competitive research funding, although specific names and grants are not mentioned. His affiliation with Ikerbasque indicates he was selected through a rigorous international recruitment process, reflecting high scientific merit. Labs and Teams: He leads the Integrative Structural and Functional Characterization of Macromolecular Assemblies Laboratory at the Biofisika Institute, fostering collaboration across disciplines to tackle complex questions in structural biology.

• Microbial Genomics
• Parasitology
• Microbiology
• +۵ مورد دیگر

Justin Pachebat is a Senior Lecturer in Microbial Genomics at Aberystwyth University's Department of Life Sciences and School of Veterinary Science. He serves as an Admissions Tutor for multiple undergraduate biology schemes and as the Scheme Leader for the MRes in Parasite Control. Dr. Pachebat holds significant professional roles, including membership on the British Society for Parasitology Council (2015-present), serving as Honorary Treasurer (2018-2022), and currently providing maternity cover for this position. He is also a member of the UK Standards for Microbiology Investigations Steering Committee (2015-present) and previously served on the Microbiology Society's Eukaryotic Microbiology Committee (2010-2014). BSc in Microbiology (Bristol University) MSc & Diploma in Medical Microbiology (London School of Hygiene and Tropical Medicine) PhD in Merozoite Surface Protein 7 characterization (Medical Research Council National Institute for Medical Research) Postdoctoral research at MRC Laboratory of Molecular Biology (2000-2007) Postdoctoral research at University of Cambridge (2007-2009) Dr. Pachebat's research focuses on applying single molecule genomics and next generation sequencing technologies to characterize pathogens and study host-pathogen-microbiome interactions. His work spans diverse areas including Anopheles microbiome research, Plasmodium species characterization, Cryptosporidium genomics, Campylobacter bacteriophage studies, and microbiome analysis related to chronic diseases. His research has practical applications in developing novel diagnostics, control methods, and vaccines for pathogens affecting animals, humans, and plants. Analysis of Dr. Pachebat's publication record reveals a consistent focus on genomic approaches to solving microbial challenges across multiple domains. His work bridges fundamental genomic research with practical applications in disease diagnosis and control, spanning agricultural, veterinary, and human health contexts. The publications demonstrate expertise in both pathogen characterization and microbiome analysis, with particular strengths in protozoan parasites and bacterial pathogens. Council Member of the British Society for Parasitology (2016) Eukaryotic Microbiology Committee of the Society for General Microbiology (2013) Honorary Treasurer of the British Society for Parasitology (2019) Member of the UK Standards for Microbiology Investigations Steering Committee (2016) Dr. Pachebat has supervised numerous postgraduate students across various programs including PhD, MPhil, MRes, and MBiol degrees. His research has been supported by multiple grants from organizations including the Biotechnology and Biological Sciences Research Council, Health Protection Agency, and commercial partnerships. Key projects include the Rumen Systems Biology initiative, Virus discovery in undiagnosed gastroenteritis cases, and Characterisation of bacterial endophytes in C4 energy crops. He has organized significant academic events including the 2018 BSP Spring meeting at Aberystwyth University. Dr. Pachebat maintains extensive collaborations with researchers across multiple institutions including the London School of Hygiene and Tropical Medicine, Public Health England, Cambridge University, Royal Veterinary College, and various veterinary and medical research centers. His work contributes to UN Sustainable Development Goals related to health, food security, and environmental sustainability through research on disease control and microbial applications.

Brian C Freemanمشاهده پروفایل

استاد

• Chromatin Structure
• Genome Organization
• Genomics
• +۶ مورد دیگر

Brian C Freeman is a Professor in the Department of Cell and Developmental Biology at the University of Illinois. He holds the distinguished title of MCB Distinguished Professorial Scholar, reflecting his significant contributions to molecular and cellular biology research. Dr. Freeman's educational background includes: B.S. in Microbiology from the University of Michigan Ph.D. in Biochemistry and Biophysics from Northwestern University Postdoctoral training at the University of California-San Francisco His research focuses on understanding the dynamic protein environment within cells, particularly how molecular chaperones contribute to cellular homeostasis. Dr. Freeman's laboratory investigates three central nuclear processes: transcription, chromatin remodeling, and genome reorganization. His work explores how molecular chaperones like Hsp90 and Hsp70 facilitate protein dynamics, prevent misassembly of complexes, and ensure proper disassembly of utilized structures. This research has significant implications for understanding aging-related diseases, cancer, and metabolic disorders. Analysis of Dr. Freeman's recent publications reveals a strong focus on molecular chaperones, particularly Hsp90, and their role in protein homeostasis. His work spans multiple disciplines including biochemistry, molecular biology, and genetics, with applications to understanding disease mechanisms. The research demonstrates an interdisciplinary approach combining biochemical, genetic, and proteomic techniques to unravel complex cellular processes. Dr. Freeman has received numerous prestigious honors and awards: MCB Distinguished Professorial Scholar (2024) Fellow, American Association for the Advancement of Science (2021) Fellow, Cell Stress Society International (2020) TUM Ambassador, Technische Universität München (2015) Friedrich Wilhelm Bessel Research Award, Alexander von Humboldt Foundation (2010) Honorary Hans Fischer Senior Fellow, TUM-IAS (2010) Educator of the year, Alumni Association the University of Illinois (2009) Fellow, American Heart Association (2000-2002) Fellow, Leukemia and Lymphoma Society (1997-2000) Fellow, Leukemia Research Foundation (1996-1997) While specific details about current students and advising are not provided in the available information, Dr. Freeman's research program appears robust with 51 research outputs documented. His work has garnered significant attention, as evidenced by social media mentions and readership metrics across multiple platforms. The research program likely involves multiple graduate students, postdoctoral researchers, and collaborators working on various aspects of molecular chaperones and cellular homeostasis. Dr. Freeman leads a research laboratory focused on molecular chaperones and their role in maintaining cellular homeostasis. His team employs a variety of biochemical, genetic, and proteomic approaches to investigate how molecular chaperones like Hsp90 facilitate protein dynamics and prevent misassembly of complexes. The laboratory appears to have strong international collaborations, as evidenced by participation in symposia and research with scientists from various institutions worldwide.