جست‌وجوی استاد و پژوهشگر

Helen Fosterمشاهده پروفایل

پژوهشگر

• Genome organisation
• Cellular and organismal ageing
• Development and differentiation
• +۵ مورد دیگر

Dr. Helen Foster is a researcher affiliated with the University of Hertfordshire , working within the School of Life and Medical Sciences and the Department of Clinical, Pharmaceutical and Biological Science . Her research focuses on genome organization, cellular aging, MTOR signaling, and endocrine-disrupting chemicals. Education : PhD in Genome Organisation (Brunel University, 2005), PGCert in Learning and Teaching in Higher Education (Brunel University, 2010) Helen employs techniques like fluorescence in situ hybridization (FISH) to study chromatin structure and nuclear architecture. Her work spans developmental biology, aging, and disease mechanisms, including studies on ovarian cancer and space radiation effects. Recent research highlights trends in microplastics in personal care products, autophagy inhibition under space conditions, and chromosome positioning in disease contexts. She collaborates internationally and contributes to open-access publications. Research Outputs : Over 24 publications, including articles on porcine development, mTOR signaling in pregnancy, and nuclear lamins in chromatin regulation.

Julien Duxinمشاهده پروفایل

دانشیار

• Genome Maintenance
• DNA Repair
• Mechanisms of DNA-Protein Crosslink Repair
• +۳ مورد دیگر

Julien Duxin is an Associate Professor and group leader at the Novo Nordisk Foundation Center for Protein Research (CPR), affiliated with the Faculty of Health and Medical Sciences at the University of Copenhagen, Denmark. He previously worked at Harvard Medical School (2012–2016) under Johannes C. Walter. Education: PhD in Biochemistry (2005–2011) from Washington University in St. Louis, advised by Sheila Stewart, and a BSc in Chemistry (2000–2004) from Missouri State University. His research focuses on genome maintenance and DNA repair , particularly mechanisms of DNA-protein crosslink (DPC) repair induced by chemotherapeutic agents. His lab developed the first in vitro system for DPC repair (2014) and investigates how repair processes integrate with DNA replication. Key collaborations involve proteins like SPRTN, RFWD3, and the proteasome. His publications (2012–2021) explore ubiquitin signaling , translesion synthesis , and replication-coupled proteolysis in DNA repair, with implications for cancer therapy. The lab's work bridges biochemistry , molecular biology , and clinical oncology , targeting novel chemotherapeutic strategies.

Niels Mailandمشاهده پروفایل

استاد

• Genome Stability
• Ubiquitin Signaling
• DNA Damage Response
• +۴ مورد دیگر

Niels Mailand is a Professor and Group Leader at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, specializing in ubiquitin and ubiquitin-like modifier signaling in genome stability. His work bridges cell biology, biochemistry, and proteomics to unravel mechanisms behind DNA damage responses and replication stress. Key Positions: 2009–Present: Professor and Group Leader at University of Copenhagen; 2005–2009: Senior Scientist at Danish Cancer Society; 2004–2005: Postdoctoral Fellow at Cancer Research UK Education: PhD (2003, University of Copenhagen); MSc in Biochemistry (1999, University of Copenhagen) Mailand's research focuses on post-translational modifications, particularly ubiquitin and SUMO pathways, to safeguard genome integrity in human cells. His group's work has identified novel proteins involved in DNA repair and elucidated the role of ubiquitin chain types in cellular responses. Recent publications highlight his exploration of understudied ubiquitin chains (K29, K27), ubiquitin-SUMO crosstalk in DNA repair, and stress response pathways. His 2025 Molecular Cell study on CRAMP1 demonstrates histone H1 biogenesis in topoisomerase II tolerance, while 2024 works probe SUMO-targeted ubiquitin ligases and epigenome regulation via SUV39H1. Scientific Awards: Silver Medal, Royal Danish Academy of Sciences and Letters (2013) EMBO Young Investigator (2013) Hardiman-Redon Prize (2005) Young Elite Researcher Award (2008) Collaborations: Extensive international partnerships in proteomics, DNA repair, and ubiquitin signaling.

• Biochemistry
• Pharmaceutical Sciences
• Cancer Research
• +۳ مورد دیگر

Nuria Martínez Sáez is a researcher at the University of Navarra , affiliated with the Faculty of Pharmacy and Nutrition and the Cancer Center Clínica Universidad de Navarra (CCUN) . Her academic work focuses on Pharmaceutical Sciences and Biochemistry , particularly in the design of mucin-based cancer vaccines and protein modification techniques . Current position: Researcher Department: Pharmaceutical Sciences Research group: Selenium derivatives for cancer, trypanosomes, and other pathologies Her research explores innovative approaches to enhance protein stability and activity through chemical modifications, with significant contributions to understanding glycosylation patterns in cancer antigens. Recent publications highlight her work on oxetane grafts , isobutylene stapling , and lectin recognition of glycopeptides , demonstrating expertise in organic synthesis and molecular immunology. Her doctoral thesis at the Universidad de La Rioja (2013) investigated rational design of mucin derivatives as cancer vaccines, supervised by Dr. Jesús Manuel Peregrina García and Dr. Francisco Corzana López. She actively develops methodologies for site-selective protein modifications that impact drug delivery and biopharmaceutical applications.

• Bioanalytical Tools
• Biophysical Techniques
• Cancer Cell Signaling
• +۷ مورد دیگر

Minjoung Kyoung is an Associate Professor in the Department of Chemistry & Biochemistry at the University of Maryland, Baltimore County (UMBC), where she leads interdisciplinary research at the chemistry-biology-physics interface. Her work focuses on developing advanced bioanalytical tools to study 4D (spatiotemporal) interactions between signaling and metabolic pathways in cancer cells, including Advanced nano-reaction chambers for transient protein-protein interactions Super-resolution imaging techniques for live-cell biological networks . Her research has been recognized through grants such as the NIGMS R01 Award (2019) and prior fellowships including the Dalalian Fellowship and SPIE Research Excellence Travel Award . She trains students in cutting-edge microscopy, nano-fabrication, and biomolecular interaction analysis, with former advisees like PhD candidate Erin Kennedy and graduate student Tao Zhang . Her publications, including in eLife and Nature Protocols , highlight mechanistic insights into calcium-triggered fusion, neurodegenerative protein interactions, and metabolic enzyme clustering. Recent projects aim to construct the first 4D map of cellular metabolic networks, bridging optical and biochemical approaches to anticipate disease mechanisms.

Joo Youn Parkمشاهده پروفایل

استادیار

• Bacterial Pathogenesis
• Vaccine Development
• Microbiology
• +۳ مورد دیگر

Dr. Joo Youn Park serves as a Research Assistant Professor in the Department of Basic Sciences at Mississippi State University's College of Veterinary Medicine (MSU-CVM), where she has been a faculty member since 2018 after joining as a Research Associate in 2011. Her dual expertise in veterinary medicine and microbiology drives interdisciplinary research at the intersection of infectious disease and biomedical innovation. Her educational journey includes: M.S. and D.V.M. from Seoul National University, Seoul, Korea Ph.D. in Microbiology and Immunology from Washington State University (2009) Post-doctoral training at the University of Idaho Dr. Park's research centers on Staphylococcus aureus pathogenesis mechanisms and vaccine development , with significant contributions to osteomyelitis modeling , bacteriophage therapy , and CRISPR-Cas9 applications against antibiotic-resistant infections. Her work bridges molecular microbiology, immunology, and translational veterinary medicine through advanced in vivo models and novel antimicrobial strategies. Analysis of her 11 publications (2015-2021) reveals consistent focus on bacterial virulence mechanisms and therapeutic innovation , evolving from foundational studies on carbohydrate-virulence relationships to cutting-edge CRISPR-engineered phage treatments. Her research spans infectious disease, orthopedics, veterinary immunology, and cancer biology, demonstrating exceptional versatility in addressing complex biomedical challenges. Her scientific recognition includes: A publication ranked in the Top 100 in Microbiology for 2017 (Nature Microbiology Collections) An Article of Significance selection by the Journal of Bacteriology (2017) While specific advising details are unavailable, Dr. Park's active research program suggests significant mentorship through MSU-CVM's Summer Research Experience and student symposiums. Her work receives support through institutional frameworks including the Center for Environmental Health Science and Global Center for Aquatic Health and Food Security. Dr. Park maintains laboratory operations within MSU-CVM's Department of Basic Sciences, collaborating with the Center for Environmental Health Science on pathogen-host interaction studies and contributing to the Global Center for Aquatic Health and Food Security's antimicrobial resistance initiatives through her Staphylococcus aureus research.

Mee Ling Munierمشاهده پروفایل

مدرس ارشد

• Immunology
• Cellular Immunology
• Vaccination
• +۶ مورد دیگر

Dr. Mee Ling Munier is a Senior Lecturer and Group Leader at the Kirby Institute within the University of New South Wales (UNSW) . Her work focuses on characterizing immune responses to vaccination and infection , particularly in human lymph nodes and peripheral blood. She leads the Vaccine Immunogenomics group within the Immunovirology and Pathogenesis Program (IVPP) , utilizing fine needle biopsy (FNB) techniques to study post-vaccination immune dynamics. UNSW Medicine & Health Kirby Institute Vaccine Immunogenomics Group

Maria Christophorouمشاهده پروفایل

استادیار

• Epigenetics
• Protein Citrullination
• Post-translational Modifications
• +۴ مورد دیگر

Maria Christophorou is a Tenure Track Group Leader at the Cambridge Stem Cell Institute and the Epigenetics Department at the Babraham Institute, University of Cambridge. She leads the Christophorou Group which focuses on understanding how developmental cues and cellular stresses are translated into epigenetic changes through the biochemical regulation of epigenetic factors, with particular emphasis on PADI enzymes and protein citrullination. Her research integrates biochemistry, cell and molecular biology, genomic and epigenetic approaches, and mouse model systems to investigate the mechanisms that modulate epigenetic regulators in health and disease. Dr. Christophorou's research expertise centers on protein citrullination, a post-translational modification that converts arginine residues to citrulline. Her work explores how peptidylarginine deiminases (PADI enzymes) regulate chromatin structure, pluripotency, and cellular responses to stress. She has made significant contributions to understanding the role of PADI4 in stem cell biology, the evolutionary origins of citrullination, and the implications of dysregulated citrullination in autoimmunity, neurodegeneration, and cancer. Her interdisciplinary approach bridges molecular mechanisms with physiological outcomes, revealing how epigenetic regulation shapes cellular identity and function during development and disease. Her recent publications demonstrate a strong focus on developing tools to study PADI enzymes, creating comprehensive maps of citrullination sites across the proteome, and investigating the evolutionary history of citrullination. The research shows progression from fundamental mechanistic studies toward translational applications, particularly in understanding how citrullination contributes to autoimmune diseases like rheumatoid arthritis and potential therapeutic targeting of PADI enzymes. Sir Henry Dale Fellow (Wellcome Trust and Royal Society) Wellcome-Beit Prize recipient EMBO Long-Term Postdoctoral Fellowship HFSP Long-Term Postdoctoral Fellowship Chancellor's Fellowship at University of Edinburgh Dr. Christophorou actively mentors PhD students, postdoctoral researchers, and visiting scientists in her laboratory. Her group has secured significant funding including the Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society, supporting research into the biochemical regulation of epigenetic factors. She has successfully guided multiple students through PhD completion, with alumni now in positions at research institutions including the MRC Human Genetics Unit, Oxford University, and industry roles. The Christophorou Group operates within the Epigenetics Programme at the Babraham Institute and maintains strong connections with the Cambridge Stem Cell Institute. The laboratory employs a multidisciplinary team of researchers with expertise spanning biochemistry, proteomics, cell biology, and computational analysis to investigate the complex roles of protein citrullination in cellular physiology and disease mechanisms.

Liana G. Apostolovaمشاهده پروفایل

استاد

• Alzheimer's Disease
• Early-onset Alzheimer's Disease
• Neuroimaging
• +۵ مورد دیگر

Liana G. Apostolova, MD, MS is an Indiana University Distinguished Professor and the Barbara and Peer Baekgaard Professor in Alzheimer's Disease Research at IU School of Medicine. She holds professorial appointments in Neurology, Radiology & Imaging Sciences, and Medical & Molecular Genetics, and serves as Associate Dean of Alzheimer's Disease Research. Dr. Apostolova directs the Clinical Core of the Indiana Alzheimer's Disease Research Center and leads the national Longitudinal Early-Onset AD Study (LEADS). Her research focuses on early-onset Alzheimer's disease, the characterization of early symptomatic and presymptomatic stages of Alzheimer's Disease, and the development and validation of sensitive imaging and genetic biomarkers. She has been instrumental in advancing neuroimaging techniques for early detection and monitoring of disease progression, with particular expertise in structural MRI and PET imaging biomarkers. Analysis of her recent publications reveals a strong emphasis on biomarker development, genetic risk factors, and therapeutic interventions for Alzheimer's disease. Her work spans from basic neuroimaging research to large-scale clinical trials, with significant contributions to understanding disease mechanisms and developing clinical applications. She has published extensively in top-tier journals including Nature, JAMA, and NEJM. Dr. Apostolova has received numerous research awards (though specific awards aren't detailed in the provided materials) and serves as Editor for Alzheimer's and Dementia: Disease Assessment and Monitoring journal. She is recognized as a leading expert in Alzheimer's disease research, particularly in the field of early-onset cases. As a dedicated mentor, she has guided numerous undergraduate, graduate, and post-graduate students as well as junior faculty researchers. Her lab includes multiple PhD students, research specialists, and analysts working collaboratively on various aspects of Alzheimer's disease research. She has secured substantial funding from NIH, foundations, and industry partners to support her research initiatives. The Apostolova Lab is affiliated with the Indiana Alzheimer Disease Center and the Center for Neuroimaging, utilizing data from major studies including LEADS, ADNI, and ImaGene. Her team comprises both current members and past researchers who have contributed to advancing our understanding of Alzheimer's disease biomarkers and pathophysiology.

Peter Toddمشاهده پروفایل

استاد

• Nucleotide repeat expansions
• Neurological disease mechanisms
• RAN translation
• +۵ مورد دیگر

Peter Todd, M.D., Ph.D., serves as the Bucky and Patti Harris Professor of Neurology at the University of Michigan Medical School , where he leads a research program focused on nucleotide repeat expansion disorders. His laboratory investigates how unstable DNA repeats cause neurological diseases through RNA-mediated toxicity and aberrant translation mechanisms, with particular emphasis on RAN translation in conditions including Fragile X-associated tremor/ataxia syndrome (FXTAS), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), ataxia, and CANVAS. Dr. Todd's research explores how repetitive genomic elements—constituting over half of human DNA—influence normal gene function and disease pathogenesis. His lab employs molecular genetics, neurobiological tools, and long-read sequencing approaches to study how RNA repeats sequester proteins and initiate non-canonical translation of toxic proteins without AUG start codons. Recent work has expanded into defining the native roles of repetitive elements in mRNA transcription and translation, with implications for common disease genetics. Analysis of Todd's 15 most recent publications (2023-2025) reveals a strong focus on mechanistic neurobiology of repeat expansion disorders , with recurring themes in RAN translation regulation, TDP-43 pathology, and advanced genomic detection methods. His work bridges fundamental molecular insights with clinical applications, evident in studies on biomarker development (e.g., skin FMRpolyG measurement) and diagnostic yield in ataxia clinics. As a physician-scientist, Todd emphasizes the bench-to-bedside research model, combining clinical neurology with molecular investigation. His lab actively recruits researchers through the University of Michigan's world-class institutional framework, supporting next-generation scientists through collaborative, interdisciplinary projects. The Todd Lab's mission explicitly includes developing therapeutics for repeat expansion disorders while fostering future scientific leaders.

Amanda Garnerمشاهده پروفایل

استاد

• Medicinal Chemistry
• RNA Biology
• Cancer Therapeutics
• +۳ مورد دیگر

Amanda Garner is a Professor in the Department of Medicinal Chemistry at the University of Michigan , focusing on RNA biology and cancer therapeutics. Her work centers on targeting RNA-binding proteins (RBPs) and translation regulation mechanisms, particularly eIF4E, which plays a critical role in oncogenic protein synthesis. Research Themes: eIF4E inhibition, RNA-protein interactions, mRNA cap analogs, and translational control in cancer. Collaborations: Active partnerships with researchers like Emilio L Cárdenas, Jeanne Stuckey, and Vibha Lama. Recent studies explore CRISPR-based screening for RNA-protein interactions, second-generation prodrugs for cancer therapy, and neuroprotective roles of αA-crystallin. She also contributes to diversity initiatives in medicinal chemistry through the ACS Division.

• Hematology
• Lymphoma
• Immunology
• +۳ مورد دیگر

Dr. Francine Foss is a Professor of Medicine (Hematology) and Dermatology at Yale School of Medicine , where she serves as Director of the Multidisciplinary T-cell Lymphoma Program and Scientific Leader of the Lymphoma CRT at Yale Cancer Center. She is also a Co-Director of the Cutaneous Lymphoma Program with Dr. Michael Girardi and President of the United States Cutaneous Lymphoma Consortium . Dr. Foss specializes in the development and testing of therapies for T-cell lymphomas, with a focus on: FDA-approved biologic drugs (e.g., Interleukin-2-Diphtheria toxin fusion protein) Stem cell transplantation and graft-versus-host disease reduction National T-cell lymphoma registry (COMPLETE Registry) and international collaborations Molecular target identification in T-cell lymphomas Novel small molecule therapeutic development (PITCH program) Her research has led to NCI-sponsored clinical trials and global PETAL Consortium studies on relapsed/refractory lymphomas. She has published extensively on: Spatial multiomics in angioimmunoblastic lymphoma Prognostic scoring systems for T/NK-cell lymphomas Vaccine response in post-transplant patients Biopsy practice standardization for cutaneous lymphomas Dr. Foss collaborates with laboratories at Yale and leads the Smilow Cancer Center's T-cell Lymphoma clinical team , attracting global patients. Her work bridges clinical practice and translational research.

• Protein Quality Control
• Ubiquitination
• Neurodegenerative Diseases
• +۴ مورد دیگر

Jin-Gu Lee is an Assistant Professor at the University of Maryland School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences. His research focuses on protein quality control mechanisms, ubiquitination, neurodegenerative diseases, and APOL1-related kidney disease. He has published 33 peer-reviewed articles with over 1,300 non-self citations. B.S., Microbiology, Keimyung University (1999) M.S., College of Medicine, Keimyung University (2004) Ph.D., College of Medicine, Keimyung University (2006) Postdoctoral Fellow, Yeungnam University (2008–2013) Research Fellow, NIH (2013–2017) Dr. Lee investigates molecular pathways in protein quality control, particularly APOL1-related kidney disease in individuals with African ancestry. His work reveals that APOL1 risk alleles disrupt ER ion homeostasis, contributing to therapeutic strategies. He also studies maternal diabetes-induced embryonic anomalies using mouse models in Dr. Peixin Yang’s lab. His publications (2024–2013) span neuroscience, molecular biology, and virology, with recent work on α-synuclein secretion via mono-UFMylation (2024) and SARS-CoV-2 protein pathogenicity (2021–2022). Earlier studies (2013–2003) address ubiquitin dynamics, TLR signaling, and oxidative stress in cellular processes. Highlight from the issue, FEBS Lett. 581:787-793 (2007) Dr. Lee collaborates with Dr. Peixin Yang’s lab, utilizing Drosophila nephrocyte and mouse models to study renal and developmental pathologies. His work bridges biochemical mechanisms with translational applications, emphasizing protein degradation, signal transduction, and disease etiology.

• Exercise Physiology
• Sports Science
• Nutrition and Exercise
• +۵ مورد دیگر

Jerónimo Aragón Vela is an Assistant Professor in the Department of Health Sciences at the Faculty of Health Sciences, University of Jaén, specializing in exercise physiology and sports science. His research investigates physiological responses to exercise, nutrition, and environmental stressors across diverse populations from children to athletes and older adults. He earned his doctorate from the University of Granada in 2017 with the thesis "Validation of α-actin as a marker of muscle damage in different sports," supervised by Dr. Luis Fontana Gallego and Dr. Jesús Rodríguez Huertas. His academic foundation combines rigorous experimental physiology with clinical applications. Research priorities include sexual dimorphism in exercise response, hypoxia adaptation mechanisms, mitochondrial function in metabolic disorders, and nutritional interventions for cardiovascular health. Recent work emphasizes sex-dependent physiological variations, marathon pacing dynamics, and molecular pathways in exercise recovery. His systematic reviews demonstrate methodological expertise in meta-analytical approaches to complex physiological questions. Current publications (2023-2025) reveal three dominant trends: 1) Sex-specific physiological responses to exercise timing and environmental stressors, 2) Nutritional modulation of metabolic and cardiovascular outcomes in diabetes and NAFLD, and 3) Translational applications of exercise physiology in aging populations and athletic performance. The integration of molecular biology with whole-body physiology characterizes his interdisciplinary approach. He actively supervises theses and contributes to academic curricula through teaching guides in animal physiology, nutrition therapy, and research ethics. His educational materials reflect commitment to evidence-based pedagogy in health sciences education.

Moniek de Maatمشاهده پروفایل

استاد

• Biochemistry of Haemostasis
• Thrombosis
• Fibrinogen Variants
• +۷ مورد دیگر

Prof. Moniek de Maat is a leading researcher in the Biochemistry of Haemostasis and Thrombosis at the Erasmus University Medical Center (Rotterdam, Netherlands) and a Visiting Professor at the University Hospital of South West Denmark. Her work focuses on fibrinogen variants , fibrin network architecture , and their roles in thrombosis , stroke outcomes , and coagulation disorders . Education: PhD in Biochemistry (1995, Erasmus University), Chemistry (Biochemistry) at Utrecht University (1987-1991). Career: Senior researcher at TNO (1991-1999, 1999-2003), Associate Professor (2003-2018), and Professor (2018-present) at Erasmus MC, Head of Hemostasis Lab (2008-2023). Research Focus: Her work explores how genetic and protein variation in fibrinogen affects clot stability , fibrinolysis , and thrombosis risk . She investigates biomarkers for acute ischemic stroke and NETosis (neutrophil extracellular traps) in cardiovascular and infectious diseases like COVID-19 . Her team studies fibrin network properties under flow and in biofilms , aiming to optimize patient treatment. Publication Trends: Recent articles (2023-2025) highlight her expertise in fibrinogen variants , NETs , and stroke biomarkers , with collaborations in diabetes , COVID-19 coagulopathy , and biofilm-related thrombosis . Key journals include J Thromb Haemost , Acta Biomater , and TH Open . Scientific Awards: Outstanding Investigator Award, International Fibrinogen Research Society (2010) Advising: She mentors PhD students (Aarazo Barakzie, Hande Eyisoylu) and postdocs (Charlene Jacqmarcq), with alumni (Tirsa Koopman). Her lab collaborates with departments in epidemiology , cardiology , pediatric hematology , microbiology , and neurology across institutions like TU Delft and MUMC+ .