جست‌وجوی استاد و پژوهشگر

Peter Bayerمشاهده پروفایل

استاد

• Protein-Protein Interactions
• Nuclear Magnetic Resonance (NMR) Spectroscopy
• Posttranslational Modification Processes
• +۴ مورد دیگر

Prof. Peter Bayer is a Professor at the University of Duisburg-Essen, leading the Structural and Medicinal Biochemistry department within the Faculty of Biology. His research focuses on elucidating protein-protein and protein-ligand interactions using biochemical, biophysical, and NMR spectroscopy techniques. Key areas include structural biology of enzymes, posttranslational modification processes, and the development of supramolecular ligands for biomedical applications. Research interests prominently feature protein structure determination, biophysical characterization of parvulins, and nanotechnology-based approaches for targeted drug delivery. Bayer’s work often integrates ultrasmall nanoparticles (e.g., gold, silver, platinum) with functionalized ligands to study protein interactions and antimicrobial activity. Publications span structural biology, nanomaterials, and enzymology, emphasizing molecular tweezers for enzyme inhibition and nanoparticle surface engineering. Collaborations with teams like those of Prof. Schrader and Dr. Beuck highlight interdisciplinary projects in drug design and biophysical chemistry.

• Selective Autophagy
• Ubiquitin Systems
• Proteasome Regulation
• +۴ مورد دیگر

Luca Ferrari is a Researcher at the Department of Biochemistry and Cell Biology, University of Vienna, affiliated with the Max Perutz Labs. He leads the Vienna International Postdoctoral Program - Fellowship project (2020-2024) focused on autophagy mechanisms in neurodegeneration. His research integrates synthetic biology, proteomics, and cellular models to study ubiquitin systems, protein aggregation, and selective autophagy pathways. Education: PhD from Max Perutz Labs, dual Dottore di Ricerca (Dott. mag.). Research Focus: Selective autophagy receptors, ubiquitin chain engineering, aggrephagy mechanisms in neurodegeneration, and proteostasis networks. Key topics include TAX1BP1/p62/NBR1 cargo receptors, ubiquitin chain synthesis, and evasion strategies of pathological proteins like Tau. Grants: Principal investigator of the Vienna International Postdoctoral Program funded project exploring autophagy's role in neurodegenerative diseases. Activities: Presented 4 poster sessions on ubiquitin chain engineering at international conferences (2024). Collaborates with institutions like Medizinische Universität Wien and Österreichische Akademie der Wissenschaften. Labs: Works within the Max Perutz Labs, a joint research center between the University of Vienna and the Medical University of Vienna.

Akihiko Ozawaمشاهده پروفایل

عضو هیئت علمی

• Neuroscience
• Pain Research
• Neuropharmacology
• +۳ مورد دیگر

Akihiko Ozawa is a Research Associate Professor in the Department of Biomedical Science at Florida Atlantic University's Charles E. Schmidt College of Medicine. His work focuses on opioid receptor systems, pain regulation, and neural circuit mechanisms, utilizing multidisciplinary approaches including mouse genetics and neuropharmacology. Ph.D. (Ehime University, 2003) M.S. (Ehime University, 2000) B.S. (Ehime University, 1998) Dr. Ozawa’s research explores opioid receptor regulation of acute, chronic, and migraine pain , with emphasis on neural circuits and nociception-behavior interactions . He pioneered the use of NOP-eGFP knock-in mice for receptor localization studies and contributed to understanding neurochemical pathways in pain and addiction. His 15 most recent publications span neuroscience, pain research, and pharmacology , addressing topics like opioid receptor plasticity , chemogenetic circuit mapping , and novel analgesic targets . Collaborative work includes nAChR antagonists for nicotine addiction and prohormone-derived peptides for cardiovascular regulation. Grants from NIH and the Department of Defense support his studies on IL-1 in pain regulation , NOP receptor agonists , and neural circuits in sensory-affective pain . He has served as PI and co-investigator on multiple NIH-funded projects.

• Proteomics
• Mass Spectrometry
• Biochemistry
• +۳ مورد دیگر

Karl Mechtler has led the Protein Chemistry Facility at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria since 1989. As Head of Facility, he directs research operations focused on advanced mass spectrometry applications in molecular and cellular biology. His facility provides critical infrastructure for proteomic analysis while conducting innovative research in protein chemistry methodologies. Mechtler's core research interests center on: Developing high-sensitivity mass spectrometry techniques Advancing crosslinking approaches for structural proteomics Optimizing single-cell proteomic workflows Analyzing posttranslational modifications Creating bioinformatic solutions for proteome analysis Improving quantitative accuracy in multiplexed proteomics Recent publications demonstrate his lab's focus on pushing technical boundaries in proteomics, with 2024-2025 research featuring innovations in Orbitrap Astral applications, FAIMS technology for peptide coverage, AI-driven data analysis, and novel crosslinking strategies. These methodological advances enable new biological insights into areas ranging from chromatin dynamics to neurological disorders. His research is supported by active grants including: 'Delineating the crossover control networks in plants' (German Research Foundation, ongoing since 2014) 'SFB F3402-B03: Chromosome dynamics' (Austrian Science Fund FWF) Mechtler leads the Protein Chemistry Facility at IMP, which maintains an active web presence detailing its research focus and capabilities. The lab specializes in developing cutting-edge mass spectrometry solutions for challenging biological questions.