جست‌وجوی استاد و پژوهشگر

Chelsie L. Brewerمشاهده پروفایل

استادیار

• Neuroscience
• Pain Research
• Neurobiology
• +۳ مورد دیگر

Chelsie L. Brewer is a faculty member at the University of Cincinnati , holding an Assistant Professor position. She earned her PhD in Neuroscience from the University of Cincinnati (2019), completed a Postdoctoral Fellowship in Anesthesiology at Stanford University (2025), and holds a BSc in Psychology from Northern Kentucky University (2015) with minors in Biology and Chemistry. Research Focus: Dr. Brewer's work explores the intersection of neurobiology , pain research , and neurodegenerative diseases , with a particular emphasis on how neonatal injury affects spinal cord circuits and chronic pain development . Her studies also investigate neuronal senescence in the dorsal root ganglia related to aging and injury, as well as dynorphin circuits in somatosensation. Grants: Dr. Brewer is the Principal Investigator on a NIAMS R00 grant (#R00AR083486) (2025-2028) titled "Novel models to study dorsal root ganglion neurons in knee osteoarthritis pain" , a federal-level project funded by the National Institute of Arthritis, Musculoskeletal and Skin Disease. Labs & Teams: She leads the Brewer Lab , focusing on neuroplasticity , neonatal injury effects , and novel pain models . Collaborators include Dr. Julie Kauer, Dr. Mark Baccei, and Dr. Luis de Lecea.

Hilary Marusakمشاهده پروفایل

دانشیار

• Childhood trauma and brain development
• Pediatric anxiety disorders
• Posttraumatic stress disorder (PTSD)
• +۷ مورد دیگر

Hilary Marusak is a tenured Associate Professor of Psychiatry and Behavioral Neurosciences at Wayne State University School of Medicine. She serves as the Director of the Division of Cannabinoids in Neurodevelopment (CANDID) and the Trauma History Investigation of Neurodevelopment in Kids (THINK) Lab. Her research focuses on childhood trauma, stress, and their impact on brain development in children and adolescents, with particular emphasis on pediatric anxiety disorders, depression, and PTSD. Dr. Marusak's educational background includes a dissertation titled "Childhood Trauma and Emotion Processing Neurocircuitry" under the supervision of Dr. Moriah Thomason. Her research employs various neuroscientific techniques including fMRI, psychophysiology (EEG/ERP, EDA, EMG), behavior, and intervention studies. Her research interests span several interconnected domains: The impact of stress and trauma during childhood on brain development Pediatric anxiety disorders, depression, and PTSD The endocannabinoid system and its relationship to mental health Effects of cannabis and cannabinoids on the developing brain Behavioral and pharmacological interventions targeting the endocannabinoid system Air pollution and its effects on adolescent brain development Dr. Marusak's recent publications reveal a strong focus on the intersection of trauma exposure, endocannabinoid signaling, and neural circuitry in youth. Her work increasingly examines how environmental factors like air pollution and cannabis exposure affect developing brains, with particular attention to fear processing, anxiety, and stress response systems. She has made significant contributions to understanding how the endocannabinoid system modulates emotional processing in children and adolescents. Among her notable achievements: Named a 2024 Rising Star in Mental Health Research Winner of the Rosalind Franklin Society Special Award in Science for endocannabinoid research Principal investigator or co-PI of studies funded by NIH, One Mind, and Michigan Cannabis Regulatory Agency Dr. Marusak is actively involved in science communication as the co-founder of Science Policy Network-Detroit and host of the BrainSTEM podcast. She teaches courses including Fundamentals of Neuroimaging and Science Advocacy and Public Engagement, demonstrating her commitment to training the next generation of scientists while engaging with the public about neuroscience.

Marco Martinaمشاهده پروفایل

استاد

• Cellular Neurophysiology
• Ion Channels
• Pain Research
• +۷ مورد دیگر

Marco Martina, MD, MSc, PhD is a Professor of Neuroscience and Psychiatry and Behavioral Sciences at Northwestern University Feinberg School of Medicine. His research is supported by multiple institutional affiliations including the Center for Autism and Neurodevelopment, Center for Translational Pain Research, Denning Ataxia Center, Northwestern University Clinical and Translational Sciences Institute (NUCATS), Northwestern University Institute of Neuroscience (NUIN), and Simpson Querrey Institute for Epigenetics. Dr. Martina received his MD from University of Trieste, Italy (1990), MS from International School for Advances Studies, Trieste (1992), and PhD from the same institution (1995). He completed postdoctoral training at University of Freiburg, Germany in Biophysics and Physiology (2000). His research focuses on two main areas: cellular neurophysiology with emphasis on action potential generation and dendritic signal integration, and the role of ion channels in neurological diseases, particularly in pain mechanisms and epilepsy. His work has revealed important insights into the TRPC3 channel's role in ataxia, the mechanisms of febrile seizures, and GABA signaling abnormalities in neuropathic pain and schizophrenia. Dr. Martina's laboratory investigates how neuronal hyperexcitability contributes to pathological conditions, with particular interest in the prefrontal cortex's role in pain perception and cognitive implications. His recent publications demonstrate continued productivity in understanding neural mechanisms of pain, ataxia, and hippocampal circuitry, with a strong emphasis on translational applications. His work shows consistent focus on ion channel physiology and its implications for neurological disorders. NARSAD Young Investigator Award, NARSAD (2008) Dr. Martina serves in significant professional capacities including as Reviewing Editor for Frontiers in Pain Research, Associate Editor for Frontiers in Synaptic Neuroscience and Frontiers in Cellular Neuroscience, and Editorial Board Member for The Cerebellum. He maintains active membership in major professional organizations including the International Association for the Study of Pain, International Brain Research Organization, and Society for Neuroscience. His research has been supported by NIH/NINDS grants including NS064091 and NS073768, Epilepsy Foundation, and Ann & Robert H. Lurie Children's Hospital of Chicago. His laboratory work spans multiple research teams focused on cellular neurophysiology, pain mechanisms, and neurodegenerative disorders, with particular emphasis on understanding selective neuronal vulnerability in conditions like ataxia.

• Biomechanics
• Exercise Physiology
• Neuromuscular System
• +۳ مورد دیگر

Dale Cannavan is a Professor of Exercise Science and Chair of the HHP Department at Seattle Pacific University (SPU). With a PhD in biomechanics/exercise physiology from Brunel University (UK), he joined SPU in 2010 after seven years at Brunel University and a career as a physical training instructor in the British Army. Dr. Cannavan holds affiliations with the National Strength and Conditioning Association (NSCA), American College of Sports Medicine (ACSM), and European College of Sports Science (ECSS). BSc, University of Surry, UK (2001) MSc, Brunel University, UK (2004) PhD, Brunel University, UK (2008) Dr. Cannavan’s research focuses on neuromuscular plasticity in response to diverse training modalities, with a particular emphasis on plantar flexors, leg stiffness during running, and muscle architecture adaptations. His work bridges biomechanics, exercise physiology, and rehabilitation, exploring mechanisms of range of motion improvement, reciprocal inhibition, and force production dynamics. At SPU, he teaches courses in Exercise Physiology, Biomechanics, and Applied Exercise Science. His publications reveal a strong focus on stretching protocols, muscle-tendon interactions, and neuromuscular adaptations. Recurring themes include the effects of static and PNF stretching on flexibility, leg stiffness modeling in running economy, and the interplay between contraction modes (concentric/eccentric) and muscle architecture changes. He has also co-authored a book chapter on strength-testing for the British Association of Sport and Exercise Sciences. Dr. Cannavan applies his expertise through affiliations with organizations like the British Olympic Medical Center, Washington State Patrol SWAT, and UK Real-Tennis Elite Squad. His practical experience includes owning a personal training business in London and serving as a Washington state director for the NSCA.

Robert Axtellمشاهده پروفایل

استاد

• Exercise Physiology
• Human Aging
• Physical Activity Interventions
• +۴ مورد دیگر

Robert Axtell is a Professor in the Exercise Science program under the Health & Movement Sciences department at Southern Connecticut State University. His academic work focuses on exercise physiology, aging, and physical activity interventions. He serves as Graduate Coordinator and has extensive experience in both teaching and research. Teaching Interests: Exercise Physiology, Human Anatomy & Physiology, Exercise & Aging Research Themes: Mobility disability prevention, autonomic function, athletic performance assessment His research spans over two decades, including collaborations with the LIFE study group and HL-PIVOT network. Recent publications examine pandemic-era physical activity support systems, CBD supplementation effects, and NCAA athlete performance metrics. Grants include studies on cardiovascular autonomic function in autistic children and nutritional interventions for glycemic control. Key presentations at American College of Sports Medicine meetings highlight work on: Muscular performance in collegiate athletes Glycemic response modulation Mobility disability prediction models Physical activity gamification

Penny Hudsonمشاهده پروفایل

مدرس ارشد

• Biomechanics
• Sport Biomechanics
• Human Sprinting Performance
• +۳ مورد دیگر

Dr Penny Hudson is a Senior Lecturer in Sport and Exercise Biomechanics at the University of Chichester, specializing in human sprinting performance and high-speed locomotion biomechanics. Her research bridges insights from cheetah biomechanics to human athletic performance, with active involvement as a trampoline gymnastics coach providing practical biomechanical support to athletes. Her educational background includes: BBSRC Funded PhD (2007-2011) from the University of London: 'The Structural and Functional Specialisations of Locomotion in the Cheetah (Acinonyx jubatus)' BSc (Hons) Bioveterinary Sciences (2004-2007) from the Royal Veterinary College Dr Hudson's research focuses on understanding the biomechanical limits of running speed through comparative analysis of cheetahs and humans. She investigates tissue mechanics, assistive device design, and movement optimization in sports contexts, particularly examining how insights from animal locomotion can enhance human sprinting performance. Her work integrates experimental biomechanics with practical athletic applications. Analysis of her 15 most recent publications (2011-2024) reveals three dominant research thrusts: (1) Sports biomechanics with emphasis on soccer kicking mechanics and energy transfer strategies; (2) Clinical biomechanics examining weight loss surgery outcomes and joint loading; and (3) Continued exploration of cheetah locomotion using advanced motion capture techniques. This trajectory shows evolution from pure animal biomechanics toward human performance applications while maintaining her foundational interest in high-speed movement. As Academic Advisor and module coordinator for Anatomy and Kinesiology (SPL103) and Tissue Mechanics and Assistive Devices (MSCBM02), she mentors students through independent projects. Her research has been supported by BBSRC funding during her PhD and DARPA funding during postdoctoral work at the Royal Veterinary College where she collaborated with Boston Dynamics on robotic design inspired by cheetah locomotion. Dr Hudson maintains active professional engagement through Society for Experimental Biology and Society for Integrative and Comparative Biology memberships, serves as Research Fellow for the Zoological Society of London, and provides journal reviewing services for Mammalian Biology. Her public outreach includes BBC News features, Science Museum exhibitions, and Channel 4's BAFTA-winning 'Inside Nature's Giants' series.

• Pharmacology
• Molecular Pharmacology
• Drug Design
• +۵ مورد دیگر

Anders A. Jensen is a Professor in the Department of Drug Design and Pharmacology at the University of Copenhagen's Faculty of Health and Medical Sciences, specializing in Molecular and Cellular Pharmacology. His research focuses on receptor pharmacology, particularly calcium-sensing receptors and serotonin 5-HT2A receptors, with significant contributions to understanding receptor modulation and drug development. Professor Jensen's research interests span molecular pharmacology, drug design, and receptor signaling mechanisms. His work particularly emphasizes calcium homeostasis disorders, allosteric modulation of receptors, and the development of novel compounds targeting serotonin receptors for neurological conditions. He has made significant contributions to understanding the structure-function relationships of G protein-coupled receptors and their implications for drug discovery. Analysis of his recent publications reveals a strong focus on receptor pharmacology with particular emphasis on calcium-sensing receptors and serotonin 5-HT2A receptors. His research spans both basic molecular mechanisms and translational applications, with work ranging from nanobody development to novel therapeutic compounds for pain management and depression. The publications demonstrate expertise in receptor kinetics, structure-activity relationships, and the molecular basis of receptor-related disorders. Professor Jensen maintains active research collaborations across multiple institutions and has founded and directs Drug Design and Pharmacology at Lophora (www.lophora.com), though this is noted as a separate activity from his university employment. His research output includes 194 publications with significant impact in pharmacology and related fields.

Karen O'Malleyمشاهده پروفایل

استاد

• Neuroscience
• Molecular Neuroscience
• Cellular Neuroscience
• +۵ مورد دیگر

Karen O'Malley is a Professor of Neuroscience at Washington University School of Medicine. She leads the O'Malley laboratory which focuses on the molecular and cellular mechanisms underlying neurological and neuropsychiatric disorders. Dr. O'Malley received her BA with Honors from California State University of Sonoma in 1971, followed by an MS in Biology from Portland State University in 1973. She completed her PhD in Biological Sciences at the University of Texas in Austin in 1980. Her research primarily investigates signal transduction pathways mediated by metabotropic glutamate receptors such as mGluR5, which are widely expressed throughout the CNS and play critical roles in neuronal excitability, brain development, and learning and memory. Notably, her lab discovered that these receptors are not only expressed on the cell surface but also on nuclear membranes where they mediate unique signaling systems associated with synaptic plasticity. The lab has also maintained a longstanding interest in dopamine receptor structure and function, having been among the first to isolate D2-like genes (D2, D3, and D4) and demonstrate their unique signaling functions. Analysis of Dr. O'Malley's recent publications reveals a consistent focus on intracellular receptor signaling, particularly the role of metabotropic glutamate receptors in synaptic plasticity, neurological disorders, and pain pathways. Her work spans molecular neuroscience, cellular signaling, and translational research with implications for understanding and treating neurological conditions. Career Research Award for Women, National Science Foundation (1987) Stanley Foundation Investigator, National Alliance for the Mentally Ill (1989-1991) NARSAD Established Investigator Award (1995) Recognition for Excellence in Mentoring (2004) Outstanding Faculty Mentor Award (2005) First Annual AWN Service Award (2006) Outstanding Faculty Postdoctoral Mentor Award (2007) Distinguished Educator Postdoctoral Research Mentoring (2010) Physician and Scientist Leadership Certification (2012) Washington University School of Medicine Alumni Distinguished Faculty Award (2013) Dr. O'Malley has been recognized extensively for her mentoring excellence, receiving multiple awards for faculty mentoring at both the undergraduate and postdoctoral levels. Her laboratory has received consistent funding to support research on receptor signaling mechanisms and their implications for neurological disorders. The O'Malley lab employs advanced techniques including CRISPR to create transgenic animal models for studying receptor function in vivo. The O'Malley laboratory maintains a strong research program investigating the molecular and cellular bases of neurological disorders. The lab has developed specialized transgenic animal models, including lines expressing mGluR5 only on the cell surface and others expressing it only on the nucleus, to test the specific roles of intracellular mGluR5 in vivo. Current research directions include studying variable tandem repeats in the D4 gene associated with ADHD, ASD, and schizophrenia using humanized mouse models.

• Pharmacology
• Experimental Pharmacology
• Bone Diseases
• +۳ مورد دیگر

Chelsea Hopkins serves as a Postdoc and Guest Researcher in the Department of Drug Design and Pharmacology at the University of Copenhagen, specializing in translational and clinical pharmacology. She is actively involved in The Graduate Programme for In Vivo Pharmacology and Experimental Animals, conducting research on rare skeletal disorders and pain mechanisms. Her primary research focuses on fibrous dysplasia and McCune-Albright syndrome, with emphasis on disease pathogenesis, nociceptive pain pathways, and preclinical model development. She employs in vivo pharmacology techniques to investigate skeletal pain mechanisms and evaluate novel therapeutic interventions for rare bone diseases, bridging basic science and clinical applications. Analysis of her 2022-2025 publications reveals a concentrated trajectory in fibrous dysplasia research, evolving from systematic model reviews to mechanistic pain studies and therapeutic development. Her work demonstrates increasing translational sophistication, moving from disease characterization to targeted pain management strategies using peripherally restricted compounds. Dr. Hopkins maintains extensive international collaborations across North America and Europe, evidenced by co-authorship with leading researchers like Collins M.T. and Boyce A. Her participation in graduate training programs highlights her role in mentoring next-generation pharmacologists through The Graduate Programme for In Vivo Pharmacology and Experimental Animals.

• Neuroscience
• Motor Control
• Amyotrophic Lateral Sclerosis Research
• +۳ مورد دیگر

Claire Francesca Meehan is an Associate Professor in the Department of Neuroscience at the University of Copenhagen's Faculty of Health and Medical Sciences. Her research focuses on motor control mechanisms, particularly in the context of neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS). She leads the Meehan Lab, which investigates neural plasticity, spinal cord function, and neuromuscular disorders using advanced neurophysiological techniques. Dr. Meehan's primary research interests span several key areas in neuroscience: Mechanisms of motor neuron dysfunction in ALS Neural plasticity in spinal cord circuits Axon initial segment dynamics and function Cholinergic modulation of motor neurons Neuromuscular junction pathology Translational approaches to neuromuscular disorders Her recent publications (2020-2025) demonstrate a strong focus on understanding the cellular and molecular mechanisms underlying ALS progression, particularly examining TDP-43 pathology, axon initial segment plasticity, and C-bouton alterations. Her work bridges basic neuroscience with clinical applications, using both rodent models and human patient data to identify potential therapeutic targets for neurodegenerative diseases. The research shows progressive investigation from molecular mechanisms to potential therapeutic interventions. Dr. Meehan is actively involved in academic service, having contributed editorials on propriospinal neurons and their role in locomotion and spinal cord injury. Her research has been cited multiple times across various publications, indicating significant impact in the neuroscience community. She has also contributed to pain research through work on PDZ domain inhibitors for neuropathic pain treatment. She leads the Meehan Lab, which appears to focus on motor control neuroscience with particular emphasis on spinal cord circuitry and neuromuscular function. The lab utilizes a range of techniques including neurophysiology, molecular biology, and animal models to investigate mechanisms of motor neuron disease and potential therapeutic interventions.

Emma Matthewsمشاهده پروفایل

دانشیار

• Genetic Neuromuscular Disorders
• Channelopathies
• Myotonic Disorders
• +۵ مورد دیگر

Dr. Emma Matthews is a Reader in Neurology at City St George's, University of London and an Honorary Consultant Neurologist at St George's University Hospitals NHS Foundation Trust, specializing in neuromuscular disorders. She serves as the Neurology Lead for the SE Genomic Medicine Service Alliance and was appointed Genomics CAG Director at St George's in October 2023. The Atkinson-Morley Neuromuscular Centre, where she works, received a Neuromuscular Centre of Excellence Award from Muscular Dystrophy UK in 2024 for both clinical and research excellence. Dr. Matthews' research focuses on genetic neuromuscular disorders, with particular expertise in channelopathies and myotonic disorders, including severe pediatric presentations and the role of neuromuscular excitability genes in sudden death. She maintains extensive collaborations with the inherited cardiac conditions team led by Professor Behr and works with Dr. Dan Osborne on developing zebrafish models of muscle development and neuromuscular disorders. Her work bridges clinical practice and laboratory research, translating genetic findings into improved patient care. Her scholarly output includes over 100 peer-reviewed publications in high-impact journals such as The Lancet, JAMA, and Brain, along with 5 book chapters. Her recent work demonstrates a strong emphasis on clinical trials for channelopathy treatments, advanced diagnostic approaches using MRI and machine learning, and deep phenotyping of neuromuscular disorders. She has led several significant multicenter studies and contributed to international clinical guidelines for neuromuscular conditions. Neuromuscular Centre of Excellence Award (2024) from Muscular Dystrophy UK Genomics CAG Director appointment (October 2023) Leadership in the SE Genomic Medicine Service Alliance Principal investigator for multiple clinical trials in neuromuscular disorders Contributor to international clinical guidelines for channelopathies Dr. Matthews directs the short course in Practical Genomics and Genetic Testing for Non-Geneticists and teaches on the Clinical Neurosciences MSc and Genomic Medicine Neurogenetics Module at City St George's. She offers MSc project placements and mentors students interested in neuromuscular disorders and genomic medicine. Her educational contributions extend to developing innovative teaching approaches that bridge clinical neurology with emerging genomic technologies.

• Magnetic Resonance Imaging
• Neurostimulation
• Medical Imaging Technology
• +۳ مورد دیگر

Giorgio Bonmassar, Ph.D. serves as an Associate Professor of Radiology at Massachusetts General Hospital, where he leads research in medical imaging technology and neurostimulation techniques. His work focuses on developing innovative solutions for MRI compatibility, neural stimulation, and medical device safety, with particular emphasis on trans-spinal magnetic stimulation for pain management and ultra-focal brain stimulation technologies. Bonmassar's research interests center around biomedical engineering applications in medical imaging, with specific focus on MRI safety for patients with implants, development of novel neurostimulation devices, and integration of EEG with MRI technologies. His work bridges engineering principles with clinical applications, particularly in the areas of neuromodulation and pain management. He has developed specialized electrode designs, micro-coil systems for precise neural stimulation, and safety solutions for medical implants during MRI procedures. Analysis of his recent publications (2023-2025) reveals a strong emphasis on engineering solutions for medical imaging challenges, with recurring themes in trans-spinal magnetic stimulation for pain treatment, reduction of RF heating in medical implants during MRI, and development of advanced electrode systems for multimodal neuroimaging. His work demonstrates a progression toward increasingly precise and specialized neurostimulation technologies, with growing applications in both adult and pediatric populations. Bonmassar serves as Principal Investigator on multiple NIH-funded research projects, including: R18EB036591 (2024-2027): Transspinal Magnetic Stimulation for Neuropathic Pain Treatment R01NS128962 (2022-2027): Metamaterials Implants for MRI R01NS120594 (2021-2024): Simultaneous fMRI and Micro-Magnetic Nervous System Stimulation R01EB024343 (2017-2021): Dense Array Image Compatible EEG for Neonatal Care R01MH111875 (2016-2021): Micro-TMS Technology for Ultra-Focal Brain Stimulation His collaborative network spans multiple institutions and specialties, with frequent co-authorship with researchers in radiology, neuroscience, biomedical engineering, and cardiology. Bonmassar's work appears to be conducted through the Martinos Center for Biomedical Imaging at Massachusetts General Hospital, where he contributes to the development of advanced imaging and stimulation technologies.

Philip F. Copenhaverمشاهده پروفایل

استاد

• Developmental Neuroscience
• Neuronal Migration
• Alzheimer's Disease
• +۳ مورد دیگر

Philip F. Copenhaver is Professor of Cell, Developmental & Cancer Biology at Oregon Health & Science University (OHSU) School of Medicine, where he directs the Graduate Program in Cell and Developmental Biology (CDB) and the Development, Differentiation, and Disease (D3) track within the Program in Biomedical Sciences. He also serves as course director in the Neuroscience Graduate Program and primary instructor for human embryology in the medical school. His educational background includes B.S. and M.S. degrees from Stanford University (1979) and a Ph.D. in Zoology from the University of Washington (1985). Postdoctoral training followed at Washington University Medical School with Paul Taghert (1986-1989) and the University of Washington with William Moody (1989-1990). Dr. Copenhaver's research centers on neuronal migration mechanisms during embryogenesis, utilizing Manduca sexta as a primary model system. His laboratory investigates conserved signaling pathways including APP as an unconventional GPCR regulating neuronal motility via Gαo, GPI-linked ephrin reverse signaling through Src kinases, and isoform-specific functions of Fasciclin II in neural development. Current projects bridge Alzheimer's disease mechanisms with developmental neurobiology through collaborations with the Oregon Brain Bank and clinical researchers. Analysis of his 2021-2023 publications reveals three converging research trajectories: (1) APP-G protein signaling in neurodegeneration, (2) estrogen receptor modulation of amyloid toxicity, and (3) conserved mechanisms of neuronal guidance. His work uniquely integrates insect models with mammalian systems to identify evolutionarily preserved pathways relevant to both developmental disorders and Alzheimer's disease. Through the CDB and PBMS programs, Dr. Copenhaver mentors graduate students in developmental neurobiology and collaborates on translational projects involving drug screening for amyloid toxicity. His laboratory maintains specialized capabilities in Manduca embryology, Drosophila genetics, and mammalian neuron culture for cross-system validation of signaling mechanisms. The laboratory operates as an integrated neuroscience hub within OHSU's Department of Cell, Developmental & Cancer Biology, utilizing the Oregon Brain Bank for human tissue analysis and collaborating with pharmacologists to test ion channel blockers and novel compounds targeting membrane estrogen receptors. Current research focuses on defining APP's normal regulatory functions to identify new therapeutic approaches for Alzheimer's disease.

• Neuroscience
• Stem Cell Biology
• Neurodegenerative Diseases
• +۵ مورد دیگر

Larry S. Sherman is a Professor in the Department of Pediatrics at Oregon Health & Science University (OHSU), where he leads the Sherman Lab. His research focuses on neural stem/progenitor cells, glial biology, and mechanisms of demyelination and remyelination in neurodegenerative diseases including multiple sclerosis (MS) and perinatal brain injury. The lab integrates molecular, biochemical, morphological, behavioral, and electrophysiological analyses to develop novel therapeutic strategies for nervous system repair. Dr. Sherman's primary research interests center on the glycosaminoglycan hyaluronan and its receptor CD44 in neural injury responses, the manipulation of extracellular matrix in neural stem cell niches to influence neurogenesis and learning, and the role of SWI/SNF chromatin remodeling factors in oligodendrocyte and neuronal differentiation. His work has revealed novel mechanisms of pain in schwannomatosis through SWI/SNF subunit regulation of sensory nerve signaling genes. The Sherman Lab extensively utilizes rodent and non-human primate models to study demyelinating diseases and identify therapeutic targets. Analysis of his recent publications (2018-2024) reveals strong emphasis on remyelination therapeutics, with significant focus on flavonoid compounds, hyaluronan metabolism inhibitors, and kynurenine pathway modulators. His work bridges basic chromatin remodeling mechanisms with translational applications in MS and perinatal brain injury, demonstrating consistent innovation in targeting extracellular matrix changes for neural repair. Key recurring themes include oligodendrocyte progenitor maturation, mitochondrial function in neuroprotection, and non-human primate modeling of human neurological disorders. The Sherman Lab operates as a multidisciplinary team at OHSU, utilizing advanced techniques including multispectral imaging for CD44 detection in aging brains, electrophysiological analyses of neural function, and sophisticated animal models ranging from murine EAE to Japanese macaque encephalomyelitis. Their research environment integrates basic molecular discovery with preclinical therapeutic development for neurodegenerative conditions.

Swetha Murthyمشاهده پروفایل

پژوهشگر

• Mechanotransduction
• Ion Channel Physiology
• Neuroscience
• +۳ مورد دیگر

Swetha Murthy is an Assistant Scientist at the Vollum Institute, Oregon Health & Science University (OHSU), leading the Murthy Lab focused on mechanotransduction and mechanically activated ion channels. Her research investigates how cells convert mechanical forces into biological signals through ion channels, with implications for touch sensation, pain, and cardiovascular regulation. Educational background: B.S. from Bangalore University, India Ph.D. in Biochemistry from State University of New York, Buffalo (2012) Postdoctoral training with Ardem Patapoutian at Scripps Research Murthy's research centers on defining molecular mechanisms of mechanotransduction, particularly through OSCA/TMEM63 ion channels. Her lab employs patch-clamp electrophysiology, calcium imaging, structural studies, and mouse genetics to investigate channel gating, biophysical properties, and physiological roles. Key interests include force-sensing mechanisms, channel diversity across species, and contributions to mammalian physiology including sensory processing and blood pressure regulation. Analysis of her 2018-2023 publications reveals consistent focus on structural and functional characterization of mechanosensitive channels, particularly TMEM63 family proteins. Her work demonstrates evolutionary conservation from plants to mammals, elucidates biophysical properties like gating thresholds, and establishes physiological relevance in sensory neurons. This research advances understanding of mechanobiology with potential applications for pain disorders and cardiovascular diseases. The Murthy Lab operates within OHSU's Vollum Institute, a premier neuroscience research environment with strengths in ion channel physiology and structural biology. The lab actively recruits postdoctoral fellows with expertise in electrophysiology, molecular biology, or mouse genetics to expand mechanotransduction research.