جست‌وجوی استاد و پژوهشگر

• Drug Delivery
• Nanomedicine
• Biopharmaceutics
• +۷ مورد دیگر

Dr. Shyh-Dar Li is a Professor and Tong Louie Chair in Pharmaceutical Sciences at the University of British Columbia's Faculty of Pharmaceutical Sciences, where he also serves as Chair of Nanomedicine and Chemical Biology. With a BSc in pharmacy from National Taiwan University (1998) and PhD in pharmaceutical sciences from UNC Chapel Hill (2008), followed by postdoctoral training at UC San Diego's Moores Cancer Center (2009), Dr. Li has established himself as a leading researcher in advanced drug delivery systems. His research focuses on developing innovative nanomedicine platforms for targeted delivery of biological therapeutics including peptides, proteins, antibodies, and nucleic acids. Dr. Li's laboratory has pioneered several novel drug delivery approaches, particularly in lipid-based nanoparticles, phospholipid-free vesicles, and polymer systems for cancer immunotherapy, pain management, and protein delivery. His work bridges fundamental nanotechnology with translational applications for difficult-to-treat diseases. Analysis of his recent publications reveals a strong emphasis on tumor microenvironment modulation, endosomal escape mechanisms for nucleic acid delivery, and non-invasive delivery routes for protein therapeutics. His research demonstrates increasing sophistication in nanocarrier engineering, with recent work incorporating machine learning approaches to optimize nanoparticle design and expanding into immunomodulatory therapies that harness the body's immune system to fight cancer. Scientific Recognition: 2014 AFPC New Investigator Award 2013 AAPS New Investigator Award in Pharmaceutics and Pharmaceutical Technologies 2013 CIHR New Investigator Award 2013 CSPS Early Career Award 2012 Prostate Cancer Foundation Young Investigator Award Dr. Li's research program has been consistently supported by major Canadian funding agencies including CIHR, NSERC, and MITACS. He actively collaborates across disciplines and accepts graduate students into his research program, focusing on cutting-edge approaches to overcome biological barriers in drug delivery. His laboratory, the Laboratory of Targeted Drug Delivery and Nanomedicine, serves as a hub for innovation in pharmaceutical nanotechnology.

Vadim Cherezovمشاهده پروفایل

استاد

• Membrane Protein Structure and Function
• G Protein-Coupled Receptors (GPCRs)
• Lipid-Protein Interactions
• +۳ مورد دیگر

Vadim Cherezov, the Ester Dornsife Chair in Biological Sciences and Professor at the University of Southern California (USC), leads groundbreaking research in membrane protein structure and function. Affiliated with the Bridge Institute, Department of Chemistry, and Michelson Center for Convergent Bioscience, his work focuses on GPCRs, ion channels, and transporters—critical targets for drug discovery. His team leverages advanced techniques like Lipidic Cubic Phase (LCP) and Serial Femtosecond Crystallography (SFX) at XFEL facilities to solve high-resolution structures under physiological conditions. Institutional Affiliations: Bridge Institute, USC Michelson Center, Department of Chemistry, Department of Pharmacology and Pharmaceutical Sciences. Key Collaborations: Katritch Lab, Kuhn Lab, NIH, European XFEL. His research explores the role of lipids in modulating GPCR function, addressing diseases like Alzheimer’s, diabetes, and cancer. By solving the structure of the A 2A adenosine receptor via sulfur SAD phasing at XFEL, Cherezov’s lab demonstrated de novo phasing without heavy atoms. This breakthrough enables structural studies of previously intractable membrane proteins. Scientific Awards & Grants: NIH R01 GM108635, U54 GM094618, U54 GM094599, R01 GM095583 Science Signaling Breakthroughs of the Year (2014) Cherezov mentors a dynamic team, including postdocs (e.g., Dong-Gyun Kim), graduate students (e.g., Behnaz Davoudinasab), and alumni (e.g., Benjamin Stauch at Eli Lilly, Nairie Michaelian at Genentech). His lab’s publications span Nature , Science , and Cell , with recent work on Science Advances (2025) addressing ABEL-FRET for GPCR dynamics.

Monica N. Fornierمشاهده پروفایل

پزشک-پژوهشگر

• Breast Cancer
• Medical Oncology
• Bone Health
• +۱ مورد دیگر

Monica N. Fornier is a physician scientist at Memorial Sloan Kettering Cancer Center (MSK) specializing in breast medical oncology . With a clinical focus on improving outcomes for breast cancer patients, she has particular expertise in bone health related to cancer therapies. Fluent in English, Italian, and French, Dr. Fornier treats international patients and contributes to multidisciplinary care teams. Education: MD from University of Milan (Italy), residency and fellowship at University Hospital of Milan and MSK Certifications: Board-certified in Internal Medicine and Medical Oncology (Europe) Her research spans neoadjuvant endocrine therapy , bone loss prevention in cancer patients, and HER2-positive breast cancer treatment beyond trastuzumab. Recent publications address ER+/HER2- breast cancer immune responses, alopecia management in survivors, and regulatory T cell mechanisms . Dr. Fornier has received multiple Castle Connolly Top Doctor awards (2023-2025) and participates in MSK clinical trials for novel cancer treatments.

Markus Heiligمشاهده پروفایل

استاد

• Addiction Neuroscience
• Alcohol Dependence
• Neuropharmacology
• +۴ مورد دیگر

Markus Heilig is a Professor of Psychiatry and Head of the Department of Biomedical and Clinical Sciences (BKV) at Linköping University. He serves as Director of the Center for Social and Affective Neuroscience (CSAN), integrating basic and clinical neuroscience to address addictive and affective disorders. His work bridges neuropharmacology, molecular psychiatry, and clinical trials. Linköping University (Current) Center for Social and Affective Neuroscience (CSAN) (Director) Wallenberg Center for Molecular Medicine (Collaborator) His research focuses on alcohol dependence mechanisms, stress-neurotransmitter interactions (e.g., CRF, substance P, endocannabinoids), and personalized medicine approaches. Using animal models and human neuroimaging (fMRI), his lab explores epigenetic changes in frontal lobe and amygdala neurons that drive compulsive alcohol use. Recent publications highlight his work on endocannabinoid modulation for PTSD treatment, neural correlates of reward choices, and pharmacological interventions targeting GABA and opioid receptors. His studies often combine brain imaging, behavioral analysis, and pharmacology. Scientific awards include the 2019 Wallenberg Clinical Scholar grant and 2017 CAN/Nordic Drugs prizes. Heilig's research is supported by Vetenskapsrådet (SEK 57 million center funding) and international donations like the Andrew J. Bock Memorial Fund.

Xenophon Papademetrisمشاهده پروفایل

استاد

• Medical Image Analysis
• Machine Learning
• Biomedical Software Development
• +۷ مورد دیگر

Xenophon Papademetris is a Professor of Biomedical Informatics & Data Science and Radiology & Biomedical Imaging at Yale School of Medicine. He serves as Associate Director of Biomedical Imaging Data Sciences at Yale Biomedical Imaging Institute and directs the Medical Software and Medical Artificial Intelligence Certificate Program. PhD in Electrical and Information Sciences from Yale University (2000) BA from Cambridge University (1994) Postdoctoral Fellowship at Yale University (2002) His research focuses on medical image analysis, machine learning, and biomedical software development. He has developed tools like BioImage Suite Web and contributed to standards committees at the Association for the Advancement of Medical Instrumentation (AAMI). His work spans modalities including MRI, CT, PET, and optical imaging. Recent publications emphasize neuroimaging analysis, explainable AI in healthcare, and multimodal data integration across species. He leads NIH-funded research under the BRAIN Initiative (R24 MH114805) and has authored a textbook on Medical Software published by Cambridge University Press. IEEE Senior Member Yale Brown-Coxe Postdoctoral Fellowship Harding Bliss Prize for Excellence in Engineering He directs the BioImage Suite Project, creating web-based image analysis tools using JavaScript and WebAssembly. His teaching includes both academic courses and a Coursera program on Medical Software with over 14,000 enrollments.

Rodolfo J. Floresمشاهده پروفایل

استادیار

• Behavioral Neuroscience
• Neuromodulators
• Prefrontal Cortex Function
• +۳ مورد دیگر

Dr. Rodolfo J. Flores serves as an Assistant Professor in the Department of Psychology within the College of Liberal Arts at the University of Texas at El Paso (UTEP). His primary research investigates neuromodulator function in the prefrontal cortex, with emphasis on acetylcholine and dynorphin systems during motivational conflict, stress responses, and addiction pathways. He employs advanced optogenetic and biosensor technologies to dissect neural circuitry underlying psychiatric conditions. Dr. Flores earned his Ph.D. in Social Cognitive and Neuroscience from UTEP in 2019, followed by postdoctoral training at the National Institute of Mental Health (NIMH). His work bridges molecular neuroscience with behavioral outcomes, focusing on how stress and substance exposure alter prefrontal cortical function. His research portfolio demonstrates consistent high-impact publication in top neuroscience journals including Nature Neuroscience , Neuron , and Psychoneuroendocrinology . Current work examines opioid neuropeptide dynamics, nicotine-alcohol interactions, and sex-specific hormonal influences on addiction behaviors. Methodologically, he specializes in genetically encoded biosensors and circuit-level manipulations to study threat processing and reward pathways. Dr. Flores teaches graduate and undergraduate courses including PSYC 4341 (Motivation & Emotion), thesis/dissertation supervision (PSYC 5395/6395), and research applications courses. His lab actively trains students through undergraduate research (RSRC 4033) and independent study opportunities (PSYC 4352).

Kanwaljeet S. Anandمشاهده پروفایل

استاد

• Pediatric Pain and Stress Neurobiology
• Neonatal and Fetal Pain Assessment
• Biomarker Development
• +۳ مورد دیگر

Dr. Kanwaljeet S. Anand is a dual-appointed Professor of Pediatrics (Pediatric Critical Care) and Anesthesiology, Perioperative & Pain Medicine at Stanford University School of Medicine. As director of the Pain/Stress Neurobiology Lab and Jackson Vaughan Critical Care Research Fund, he serves as Editor-in-Chief of Pediatric Research and maintains active membership in Bio-X, MCHRI, and Wu Tsai Neurosciences Institute. Rhodes Scholar with D.Phil from University of Oxford Harvard postdoctoral fellowship and Boston Children's Hospital residency Founded Harmony Health Clinic - Arkansas' largest charitable medical-dental facility A translational researcher with 30+ years of impact, Dr. Anand established the first scientific framework for infant pain perception and developed novel pain assessment methodologies. Current research focuses on: Hair biomarker analysis for stress and social affiliation (cortisol/oxytocin) Machine learning systems for objective pain detection in non-verbal infants Biopsychosocial interventions for stress reduction in disadvantaged youth Neurotoxicity mechanisms of sedatives in developing brains Global NICU opioid usage patterns through the NeoOpioid Consortium His work has yielded over 260 publications and significant advances in: Pediatric pain management protocols Neonatal stress biomarker development Critical care neurobiology insights Community health initiatives AI-driven clinical decision support systems Scientific Recognition 9th Annual 'In Praise of Medicine' Public Address, Erasmus University (2014) Nightingale Excellence Award (2016) Honorary Doctorate from University of Örebro (2019) NIH SBIB-H82 Study Section Chair (2018) Multiple IASP and American Pain Society awards Swedish Academy of Medicine's Nils Rosén von Rosenstein Award (2009) St. Jude Endowed Chairholder (2010) As mentor to Med Scholar Anjali Gupta and advisor to numerous professional bodies, Dr. Anand maintains active clinical leadership in Pediatric Intensive Care while advancing computational approaches to pain detection through collaborations with Stanford's AI researchers.

Tyler Johnsonمشاهده پروفایل

دانشیار

• Natural Products Chemistry
• Bioorganic Chemistry
• Medicinal Chemistry
• +۲ مورد دیگر

Tyler Johnson, PhD, is an Associate Professor in the Department of Natural Sciences and Mathematics at Dominican University of California's School of Health and Natural Sciences. His expertise lies in Natural Products Chemistry , Bioorganic Chemistry , and Medicinal Chemistry , with a focus on biomedical applications. Johnson's research emphasizes discovering therapeutic lead compounds and molecular probes from marine and terrestrial natural products. His research team investigates chemotypes like mycothiazole , zampanolide , fijianolide , and latrunculin from Indo-Pacific marine sponges. These compounds exhibit potent cytotoxicity (IC50 1~5 nM) against cancer cell lines through mechanisms including microfilament disruption , mitochondrial complex I inhibition , and microtubule stabilization . Current work explores mycothiazole as a molecular probe for mitochondrial aging. Key publications span 2024-2002, covering topics from sponge-derived anticancer agents to inflammation modulation and environmental toxicology. Johnson's laboratory engages in large-scale natural product isolation, spectroscopic validation, and semi-synthetic medicinal chemistry to optimize therapeutic leads. His work integrates undergraduate and graduate students into interdisciplinary biomedical research.

Parisa Hosseinzadehمشاهده پروفایل

استادیار

• Protein Design
• Computational Biochemistry
• Biosensors
• +۳ مورد دیگر

Parisa Hosseinzadeh is an Assistant Professor in the Department of Bioengineering at the University of Oregon. Her research focuses on computational protein design and structure-guided rational protein/peptide engineering, with applications in enzyme design, biosensors, and biomedical solutions. She holds a B.Sc. from the University of Tehran, a Ph.D. from the University of Illinois (advisor: Yi Lu), and a postdoc at the University of Washington in David Baker's lab. Her lab emphasizes interdisciplinary approaches at the intersection of computer science, chemistry, and biology, prioritizing diversity and inclusion in STEM. Key projects include designing cyclic peptides as enzyme inhibitors, developing methods for tuning redox potentials in metalloproteins, and creating tools to combat biomedical challenges. Lab members include postdocs, graduate students (e.g., Noora Azadvari, Andrew Powers), and undergraduates. Notable achievements include NSF grants, the Baxter Foundation Award, and the Hans Horse Meyer Award. The lab also emphasizes mentorship, collaborative culture, and outreach initiatives.

Sonia Mayoralمشاهده پروفایل

استادیار

• Glial Cell Biology
• Myelin
• Neuron-Glia Interactions
• +۳ مورد دیگر

Sonia Mayoral is the Robert J. and Nancy D. Carney Assistant Professor of Neuroscience at Brown University. Her research focuses on studying cell-cell interactions in the brain, particularly the development and function of oligodendrocytes – glial cells critical for myelin formation. She explores how these cells contribute to myelination, remyelination processes, and their roles in neurological disorders like multiple sclerosis. Her work integrates cellular neuroscience, immunology, and drug screening methodologies. Research interests include glial cell biology, neuron-glial interactions, and the molecular mechanisms governing myelin repair. She investigates how environmental cues and signaling pathways regulate oligodendrocyte differentiation and function. Notable projects involve developing high-throughput screening platforms for MS therapeutics and studying sex-specific responses to neurodegenerative challenges. Her lab’s recent work includes clinical trials (Re-WRAP) evaluating Bazedoxifene for remyelination in women, and fundamental studies on regulatory T cell roles in myelin regeneration. She also examines how mechanical stimulation and epigenetic changes influence oligodendrocyte behavior. Her research bridges basic science and translational efforts, aiming to advance treatments for myelin-related disorders. Dr. Mayoral’s lab is active at Brown University, with a dedicated website detailing ongoing projects and collaborations. While no specific grants or students are listed here, her work reflects a strong focus on interdisciplinary approaches to neurodegenerative disease mechanisms.

Rosalyn Moranمشاهده پروفایل

استاد

• Computational Neuroscience
• Computational Psychiatry
• Neurodegenerative Diseases
• +۵ مورد دیگر

Professor Rosalyn Moran is a Professor of Computational Neuroscience and Deputy Director of King's Institute for Artificial Intelligence at King's College London. She holds roles in the Department of Neuroimaging and School of Neuroscience within the Institute of Psychiatry, Psychology & Neuroscience. Her research focuses on computational neuroscience, computational psychiatry, and neurology, particularly integrating brain connectivity with algorithmic principles like the free energy principle. She explores neurotransmitter roles in decision-making and disease modeling, with applications in artificial intelligence and neurodegenerative disorders. Moran serves as an editor for Neuroimage and collaborates with leading institutions. Key projects include global neuroimaging initiatives (UNITY) and low-field MRI advancements in low-resource settings. Her work bridges Bayesian inference, AI, and neurobiology, with recent emphasis on pediatric neuroimaging and treatment-resistant psychosis. Education & Research Interests Rosalyn Moran's research spans computational psychiatry, neuroimaging techniques, and AI applications in healthcare. Her lab investigates serotonin and dopamine signaling, brain connectivity patterns, and predictive coding frameworks. Notable contributions include modeling NMDA receptor dysfunction in encephalitis and developing super-resolution MRI methods for global health contexts. Grants & Collaborations Funded projects include MRC Human Functional Genomics (2024-2028), NIHR Maudsley BRC (2022-2027), and Gates Foundation initiatives for low-field MRI enhancement. Collaborators include Karl Friston (UCL), Read Montague (Virginia Tech), and Klaas Enno Stephan (University of Zurich). Recent events include presenting the Free Energy Principle's role in generative AI (May 2023). Labs & Teams Her lab focuses on computational psychiatry and AI-driven neuroimaging solutions, collaborating with the King’s Global Health Institute to advance medical imaging accessibility in low-income regions.

Kuo-Fen Leeمشاهده پروفایل

استاد

• Molecular Neurobiology
• Nerve Regrowth
• Spinal Cord Injury
• +۵ مورد دیگر

Kuo-Fen Lee, PhD is a Professor at the Salk Institute for Biological Studies, holding the prestigious Helen McLoraine Chair of Molecular Neurobiology. He leads the Clayton Foundation Laboratories for Peptide Biology, where his research focuses on nerve regeneration, spinal cord injury, and molecular mechanisms underlying neural development and neurodegenerative diseases. His work bridges basic neuroscience with potential therapeutic applications for conditions like ALS, paralysis, and Alzheimer's disease. Dr. Lee received his educational training from multiple prestigious institutions: a degree in Plant Pathology from National Taiwan University; an MS in Cancer Enzymology and Cell Differentiation from National Yang-Ming Medical College, Taiwan; a PhD in Endocrinology from Baylor College of Medicine, Houston; and completed his postdoctoral training at the Whitehead Institute for Biomedical Research. His primary research interests center on understanding why humans cannot regenerate damaged nerves while many other animals can. Dr. Lee has made significant discoveries regarding the p45 protein, which promotes nerve regrowth in mice but is absent in humans (who instead have p75, which inhibits nerve growth). His laboratory also studies neuregulin signaling, neuromuscular synapse formation, and the role of various proteins like nestin in neural development and maintenance. His work often employs mouse models to investigate spinal cord injury, pain pathways, and neurodegenerative conditions. Analysis of Dr. Lee's recent publications reveals a consistent focus on molecular neurobiology with particular emphasis on neural signaling pathways, synaptic maintenance, and nerve regeneration mechanisms. His research spans from basic molecular mechanisms to potential therapeutic applications, with increasing attention to pain pathways, Alzheimer's disease models, and the intersection of neuroscience with immunology and metabolism in recent years. As holder of the Helen McLoraine Chair of Molecular Neurobiology, Dr. Lee has received significant institutional recognition for his contributions to neuroscience. While specific awards aren't detailed in the provided text, his sustained funding and leadership position indicate substantial peer recognition in his field. Dr. Lee's research program involves extensive collaboration with other neuroscience laboratories, as evidenced by his numerous co-authored publications across various neuroscience subdisciplines. His work has been consistently funded, allowing for the maintenance of an active research laboratory focused on nerve regeneration and molecular neurobiology. The Clayton Foundation Laboratories for Peptide Biology serves as the primary research environment for Dr. Lee's team, where they investigate molecular mechanisms of nerve development, regeneration, and degeneration using advanced genetic, molecular, and cellular approaches. The laboratory maintains active research programs in multiple areas of neural signaling and development.

• Medicinal Chemistry
• Synthetic Organic Chemistry
• Chemical Biology
• +۶ مورد دیگر

Jonathan Ellman is the Eugene Higgins Professor of Chemistry and Professor of Pharmacology at Yale University, with joint appointments in the Department of Chemistry and the Department of Pharmacology at the Yale School of Medicine. He is also affiliated with the Yale Cancer Center and the Developmental Therapeutics program. Education: PhD, Chemistry, Harvard University (1989) BS, Chemistry, MIT (1984) NSF Postdoctoral Fellow, University of California at Berkeley (1992) Dr. Ellman's research lies at the intersection of synthetic organic chemistry and biomedical science, focusing on the development of novel synthetic methodologies and their application to drug discovery. His work emphasizes catalysis, particularly in C–H activation and enantioselective synthesis, with a strong interest in sulfur-containing compounds such as sulfoximines and sulfilimines as bioactive motifs. His lab has pioneered methods for constructing complex amine and amide architectures with quaternary centers, which are valuable in medicinal chemistry. A recent focus includes targeting opioid receptors for pain therapeutics with reduced side effects. His research has led to over 350 publications and significant contributions to chemical biology and pharmaceutical sciences. His recent publications reveal a consistent focus on catalytic methodologies, sulfur chemistry, and computational drug design, particularly in targeting opioid receptors. Themes include enantioselective synthesis, C–H functionalization, and the exploration of underutilized heteroatom-containing functional groups in drug discovery. Scientific Awards and Honors: Member, American Academy of Arts and Sciences (2016) Yale Dylan Hixon ’88 Prize for Teaching Excellence in the Natural Sciences (2016) Herbert C. Brown Award for Creative Research in Synthetic Methods (2012) GlaxoSmithKline Chemistry Scholar Award (2010) Pedler Award, Royal Society of Chemistry (2010) Dr. Ellman has trained numerous researchers and maintains a highly collaborative research program, evidenced by frequent co-authorship with colleagues across Yale. His lab, accessible via ellman.chem.yale.edu , is part of Yale’s broader research ecosystem in chemical biology and therapeutics. He has received continuous grant support, particularly in the areas of synthetic methods development and translational chemical biology, although specific grants are not detailed in the text.

• Alcoholism
• Comorbidity
• Neurobiology
• +۵ مورد دیگر

Ismene Petrakis is a Professor of Psychiatry at Yale School of Medicine and Director of the Mental Health Service Line at VA Connecticut Healthcare System since 2010. She also leads the ACGME-accredited Addiction Psychiatry Residency program at Yale and serves as Principal Investigator for NIAAA- and NIDA-funded training grants . Her clinical and research focus bridges alcohol dependence , comorbid psychiatric disorders , and veterans' health . Research Pillars : Pharmacotherapies for dually diagnosed patients Neurobiological mechanisms of alcoholism PTSD-alcohol comorbidity Genetic risk in substance use Methodological Expertise : Multicenter clinical trials Neurotransmitter system analysis Population-based epidemiology Translational neuroscience Key Publications (2024-2025) : Investigations into GLP1R gene expression in kidney disease Dexmedetomidine for comorbid alcohol-PTSD Cognitive training combinations for alcohol use disorder PTSD treatment effects on neurobiological markers Chronic pain-alcohol use syndemic Collaborative Networks : Yale-Drug use, Addiction, and HIV prevention Research Scholars Neuroscience Research Training Program Collaboration with Department of Anesthesiology

• Positron Emission Tomography (PET) Imaging
• Neurochemistry
• Computational Neuroscience
• +۴ مورد دیگر

Professor Evan Morris is a faculty member at Yale School of Medicine in the Radiology and Biomedical Imaging department, with secondary appointments in Biomedical Engineering and Psychiatry. His work combines advanced kinetic modeling and dynamic PET imaging to visualize neurotransmitter dynamics in the brain. PhD in Chemical Engineering from Case Western Reserve University (1991) Postdoctoral fellowship at Massachusetts General Hospital (1995) Morris specializes in creating "dopamine movies" through PET imaging, revealing transient neurochemical fluctuations related to addiction, Parkinson's disease, and stress responses. His group develops novel parametric imaging methods for faster drug discovery and disease biomarker identification. Recent publications focus on: Nonsteady-state PET modeling Stress-induced opioid receptor connectivity Exercise effects on Parkinson's neuropathology EC50 image quantification Scientific recognitions include: Fulbright Senior Scholar (2015) Yale Graduate Mentor of the Year (2013) He serves as Principal Investigator for studies on nicotine addiction and collaborates across Yale's Morris Lab , PET Core , and Neural Disorders programs, advancing applications in Medical Imaging , Neurochemistry , and Biomedical Engineering .