جست‌وجوی استاد و پژوهشگر

Yaojun Zhangمشاهده پروفایل

استادیار

• Biological Physics
• Biophysics
• Theoretical Physics
• +۳ مورد دیگر

Yaojun Zhang is an Assistant Professor in the Department of Physics & Astronomy and the Department of Biophysics at Johns Hopkins University. She earned her PhD in Physics from the University of California, San Diego (2015), followed by postdoctoral fellowships at the Princeton Center for Theoretical Science (2015-2018) and the Princeton Center for the Physics of Biological Function (2018-2021). Her research focuses on biological physics, particularly the complex behaviors of biomolecules and their assemblies across scales—from single-molecule folding to intracellular transport and biomolecular phase separation. She employs theoretical, mathematical, and computational tools to bridge biological questions with physical principles. Education PhD in Physics, University of California, San Diego (2015) Postdoctoral Fellowships: Princeton University (2015-2021) Research Interests Her group studies biomolecular condensates and liquid-liquid phase separation, exploring how microscopic interactions determine macroscopic properties of cellular compartments. Key areas include: Biomolecular condensate formation and dynamics Phase separation in cellular environments Interactions between biomolecules and cellular components Biophysics of intracellular transport Collaborations & Tools Zhang collaborates with experimentalists to validate theoretical models and develops frameworks for understanding condensate functions, such as surface tension, stoichiometry, and phase diagrams. Her work addresses challenges like condensate stability, molecular exclusion, and biological function regulation. Labs & Resources She leads the Zhang Lab , which integrates experimental and computational approaches. Her team’s research is supported by resources at the Bloomberg Center for Physics and Astronomy.

• Drug Delivery
• Nanomedicine
• Biopharmaceutics
• +۷ مورد دیگر

Dr. Shyh-Dar Li is a Professor and Tong Louie Chair in Pharmaceutical Sciences at the University of British Columbia's Faculty of Pharmaceutical Sciences, where he also serves as Chair of Nanomedicine and Chemical Biology. With a BSc in pharmacy from National Taiwan University (1998) and PhD in pharmaceutical sciences from UNC Chapel Hill (2008), followed by postdoctoral training at UC San Diego's Moores Cancer Center (2009), Dr. Li has established himself as a leading researcher in advanced drug delivery systems. His research focuses on developing innovative nanomedicine platforms for targeted delivery of biological therapeutics including peptides, proteins, antibodies, and nucleic acids. Dr. Li's laboratory has pioneered several novel drug delivery approaches, particularly in lipid-based nanoparticles, phospholipid-free vesicles, and polymer systems for cancer immunotherapy, pain management, and protein delivery. His work bridges fundamental nanotechnology with translational applications for difficult-to-treat diseases. Analysis of his recent publications reveals a strong emphasis on tumor microenvironment modulation, endosomal escape mechanisms for nucleic acid delivery, and non-invasive delivery routes for protein therapeutics. His research demonstrates increasing sophistication in nanocarrier engineering, with recent work incorporating machine learning approaches to optimize nanoparticle design and expanding into immunomodulatory therapies that harness the body's immune system to fight cancer. Scientific Recognition: 2014 AFPC New Investigator Award 2013 AAPS New Investigator Award in Pharmaceutics and Pharmaceutical Technologies 2013 CIHR New Investigator Award 2013 CSPS Early Career Award 2012 Prostate Cancer Foundation Young Investigator Award Dr. Li's research program has been consistently supported by major Canadian funding agencies including CIHR, NSERC, and MITACS. He actively collaborates across disciplines and accepts graduate students into his research program, focusing on cutting-edge approaches to overcome biological barriers in drug delivery. His laboratory, the Laboratory of Targeted Drug Delivery and Nanomedicine, serves as a hub for innovation in pharmaceutical nanotechnology.

Ron Drorمشاهده پروفایل

استاد

• Computational Biology
• Machine Learning
• Molecular Dynamics Simulation
• +۶ مورد دیگر

Ron Dror is the Cheriton Family Professor of Computer Science at the Stanford Artificial Intelligence Lab , with courtesy appointments in Structural Biology and Molecular & Cellular Physiology . He also holds affiliations with Bio-X, the Institute for Human-Centered Artificial Intelligence (HAI), the Institute for Computational and Mathematical Engineering (ICME), Sarafan ChEM-H, and the Wu Tsai Neurosciences Institute. Education: PhD in Electrical Engineering and Computer Science, MIT MPhil in Biological Sciences, University of Cambridge (Churchill Scholar) BS in Mathematics and Electrical & Computer Engineering, Rice University (summa cum laude) Ron leads a multidisciplinary research group that combines molecular simulation and machine learning to study biomolecular structure, dynamics, and function. His work focuses on developing computational methods to accelerate drug discovery by predicting molecular interactions and designing more effective therapeutics. Current projects include the PENSA software library for analyzing biomolecular ensembles and FRAME framework for structure-based ligand design. His research has produced groundbreaking work on G-protein-coupled receptors (GPCRs) , RNA structure prediction , and mitochondrial transport mechanisms . Key publications highlight applications of geometric deep learning and molecular dynamics simulations in structural biology. Scientific Awards: Cheriton Family Professorship (2023) Two Gordon Bell Prizes (2014, 2009) Best Paper Awards at NeurIPS (2021), IPDPS (2013), SC11 (2011), SC09 (2009), SC06 (2006) Science Magazine Top 10 Breakthrough (2010) Fulbright Scholarship , NSF Fellowship , DoD Fellowship , Whitaker Foundation Fellowship Ron has advised numerous doctoral and master’s students including EJ Fine , Masha Karelina , and Briana Sobecks . His lab collaborates with experimentalists across academia and industry, applying computational methods to diverse biomedical problems such as RNA structure prediction , GPCR signaling , and mitochondrial metabolism .

Outi Salo-Ahenمشاهده پروفایل

مدرس ارشد

• Pharmaceutical Chemistry
• Molecular Modeling
• Drug Design
• +۵ مورد دیگر

Senior Lecturer Outi Salo-Ahen is affiliated with Åbo Akademi University's Faculty of Natural Sciences and Engineering , Department of Pharmacy. Her research focuses on computational pharmacology, drug design, and pharmaceutical chemistry, particularly targeting chemokine receptors (CCR5/CXCR4) and transient receptor potential channels (TRPA1) for therapeutic applications. Doctor of Pharmacy (2006, University of Kuopio/UEF) MSc in Pharmaceutical Chemistry (2001, UEF) BSc in Pharmacy (1999, UEF) University Pedagogy Modules 1-5 (2012-2015) Her work contributes to UN Sustainable Development Goals through education and pharmaceutical innovation . Recent research trends include: Antimicrobial resistance solutions TRPA1 channel modulation Nanotechnology-enabled drug delivery Multi-target HIV-1 inhibitors 3D printing of biocompatible materials Computational analysis of nucleic acid frameworks She actively supervises doctoral projects, serves on assessment panels, and leads collaborations like Nordic Pharmaceutical Translation and Innovation. Her 60+ publications demonstrate expertise in molecular modeling and drug discovery.

Donald Rioمشاهده پروفایل

استاد

• Nucleic Acid Transactions
• Transposable Elements
• RNA Binding Proteins
• +۳ مورد دیگر

Donald Rio holds the Richard and Rhoda Goldman Distinguished Chair in the Biological Sciences and is a Professor of Biochemistry, Biophysics, and Structural Biology. He is affiliated with the Division of Biochemistry and Molecular Biology and the Center for Integrative Genetics. His lab focuses on nucleic acid transactions, including transposable element mobilization (P elements) and RNA binding protein mechanisms controlling alternative splicing. Research highlights include studies on THAP9 proteins in humans/zebrafish, cryo-EM structural analysis of transposase-DNA complexes, and splicing regulation in neurodegenerative diseases like ALS and Parkinson’s. His work combines biochemical, genetic, and computational approaches, including the development of the Junction Usage Model (JUM) for splicing analysis. Research interests span transposition mechanisms linked to HIV integration, immune system recombination, and evolutionary genome dynamics. His team investigates how RNA binding proteins like hnRNPA1 influence splicing in disease contexts, with projects involving CRISPR-based models and patient RNA-seq data analysis. Collaborations include studies on splicing accuracy across tissues and age, and the impact of splicing defects in neurodegenerative disorders. Key awards include the Goldman Chair. His lab’s contributions bridge fundamental molecular mechanisms with translational applications in genetic disease modeling and drug discovery. Recent work focuses on isogenic stem cell models (iSCORE-PD) for Parkinson’s research and structural biology insights into transposase function. Grants and projects involve NIH funding for ALS splicing studies and collaborations with institutions like the Buck Institute. His lab actively publishes in top journals such as Genome Research , PNAS , and Nature , with a strong emphasis on cryo-EM and bioinformatic methods.

Jerelle A. Josephمشاهده پروفایل

استادیار

• Biomolecular Condensates
• Phase Separation
• Computational Biology
• +۴ مورد دیگر

Jerelle A. Joseph is an Assistant Professor at Princeton University , affiliated with the Department of Chemical and Biological Engineering and the Omenn-Darling Bioengineering Institute . They also hold associated faculty roles in the Department of Chemistry , Andlinger Center for Energy and the Environment , Princeton Institute for Computational Science and Engineering , and the Biophysics Graduate Program . Research Interests : The Joseph Group investigates the physicochemical principles governing biomolecular condensate formation, dissolution, and misregulation . Their work focuses on phase separation mechanisms , computational modeling of protein-RNA interactions , and engineering condensates for biomedical and sustainability applications , including therapeutic targeting of neurodegenerative diseases and design of synthetic microreactors . Scientific Awards : NIGMS MIRA (R35) Award (2024) Biophysical Society Award Lecture (2024) Chan Zuckerberg Initiative Investigator (2023) Postdoctoral Award, Biophysical Society IDP Subgroup (2022) Rising Star in Soft and Biological Matter (University of Chicago, 2020) Advising : Dr. Joseph advises graduate students including Ananya Chakravarti , Dominic Curtis , and Pablo Garcia . The group develops chemically-specific coarse-grained models using molecular dynamics , Monte Carlo sampling , and machine learning to study condensate microstructure , aging dynamics , and surface electrostatics .

Oliver Seitzمشاهده پروفایل

استاد

• Chemical protein synthesis
• DNA/RNA-templated reactions
• Bioorganic synthesis
• +۶ مورد دیگر

Prof. Oliver Seitz leads the Bioorganic Synthesis research group at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Humboldt University of Berlin. His lab focuses on cutting-edge chemical biology approaches for protein/nucleic acid interrogation, with recent work advancing DNA/RNA-programmed assemblies for cellular imaging and therapeutic applications. Research spans chemical protein synthesis, glycoprotein/phosphoprotein engineering, and nucleic acid-templated reactions. Key innovations include Forced Intercalation (FIT) probes for wash-free RNA imaging, loss-of-affinity principles for catalytic efficiency, and peptide-PNA conjugates for targeted cellular delivery. The group actively develops tools for live-cell protein labeling and biomolecular spatial screening. Recent publications (2021-2024) emphasize fluorescence-based detection systems, catalytic templated reactions, and therapeutic peptide synthesis. Trends show increasing sophistication in multi-dye probes, glycan engineering, and RNA-triggered pro-drug activation. Scientific awards include: Max Bergmann Award (2019) Prof. Seitz actively advises doctoral students, with recent graduates Marvin Björn Stutz (2023, magna cum laude ), Dino Gluhacevic von Krüchten (2023, summa cum laude ), and Sophie Schöllkopf (2023, magna cum laude ). Current PhD candidates include Ekaterina Kazakova (glycoprotein synthesis), Alina Herfort (phosphoproteins), and Lina-Marie Beck (peptide-nucleic acid conjugates), with postdocs like Dr. Mandana Oloub (viscosity sensors). The Bioorganic Synthesis lab operates within Berlin's vibrant chemical research ecosystem, utilizing specialized techniques for chemical protein synthesis and nucleic acid detection. Recent team growth reflects ongoing projects in RNA imaging, catalytic templated reactions, and therapeutic conjugate development, supported by open positions for new researchers.

Adam Caparcoمشاهده پروفایل

استادیار

• Agricultural Biotechnology
• Environmental Biotechnology
• Enzyme Immobilization
• +۶ مورد دیگر

Adam Caparco is the DiPietro Assistant Professor of Chemical Engineering at Northeastern University, with a 25% joint appointment in the Department of Chemistry and Chemical Biology. He leads the Caparco Research Group, focusing on agricultural and environmental biotechnology, enzyme immobilization, and protein assemblies. His work integrates plant virology, nanotechnology, and molecular engineering to address sustainability challenges in agriculture and environmental remediation. He is a member of the Institute for Plant-Human Interface and holds affiliations with Northeastern’s College of Engineering and School of Arts and Sciences. Education: B.S. in Chemical and Biomolecular Engineering from UCLA (2015), Ph.D. from Georgia Tech (2020) under Julie Champion and Andreas Bommarius, followed by a USDA NIFA Postdoctoral Fellowship at UC San Diego under Nicole Steinmetz. His research spans plant immunoengineering, biomanufacturing in plants, and protein-based nanomaterials for bioremediation. Research Interests Plant excretion pathways for pathogen defense and environmental remediation Design of immobilized enzymes for green chemical synthesis Plant virus nanoparticles for nucleic acid delivery and immunity modulation Multifunctional protein engineering for sustainable agriculture Recent articles highlight advancements in plant virus-based delivery systems, enzyme immobilization strategies, and nano-enabled precision agriculture. Awards include the USDA NIFA Postdoctoral Fellowship. Caparco advises graduate and undergraduate researchers, including Julia Hilgemberg Merlin (PhD ChE), Olha Bereziuk (PhD CCB), and Paul Carter (PhD ChE). He collaborates widely and seeks to expand interdisciplinary research in plant biotechnology. Labs/Teams: Caparco Research Group (EXP 420 lab, EXP 530B office) and the Institute for Plant-Human Interface.

• Peptide self-assembly
• Amyloid structures
• HIV transmission mechanisms
• +۵ مورد دیگر

Bradley Nilsson is a Professor of Chemistry at the University of Rochester, Department of Chemistry. He leads the Nilsson Group, focusing on peptide self-assembly, amyloid structures, and their applications in biomedicine and materials science. His work bridges organic, biological, and materials chemistry, with notable contributions to amyloid-inspired hydrogels and HIV transmission mechanisms. He received the 2016 Goergen Award for Excellence in Teaching and the 2012 NSF CAREER Award. Education: PhD in Organic Chemistry (2003, University of Wisconsin-Madison), postdoctoral research at UC Irvine. He joined Rochester in 2006. Research interests include molecular recognition in amyloid peptides, SEVI fibrils' role in HIV transmission, and hydrogel development for tissue engineering. His lab has pioneered studies on stimulus-responsive self-assembly and co-assembly of peptides. Key achievements include the reductive trigger for peptide hydrogelation (JACS 2010), and NIH-funded work on anti-HIV microbicides. Current projects explore amyloid-β oligomer toxicity, SEVI mechanisms, and functional biomaterials from simple amino acid derivatives. Lab members include graduate students Elena Quigley, Melissa Jagrosse, Francine Yanchik, Hannah Distaffen, and Chris Jones. The lab collaborates on interdisciplinary projects funded through NIH and NSF grants.

Ulrich F Keyserمشاهده پروفایل

استاد

• Applied Physics
• Biophysics
• Nanotechnology
• +۳ مورد دیگر

Professor Ulrich F Keyser is a faculty member at the University of Cambridge, affiliated with the Cavendish Laboratory and the Physics of Medicine department. His research focuses on applied physics in biological and soft systems, utilizing advanced techniques such as nanopore sensing, microfluidics, and DNA nanostructures. Keyser's work bridges biophysics, nanotechnology, and molecular biology, with applications in biomedical engineering and biomimetic systems. Research interests include: Single-molecule sensing and manipulation Nanopore-based diagnostics and RNA/DNA analysis Synthetic cell models and membrane biophysics DNA/RNA nanostructures and programmable sensors Ion transport and molecular dynamics in confined systems Biophysics of protein oligomers and nucleic acid modifications His recent publications highlight advancements in nanopore detection of RNA mutations, DNA structural studies, and programmable biosensing technologies. Keyser's laboratory employs interdisciplinary approaches combining physics, chemistry, and biology to address fundamental and applied questions in biomedical and soft matter systems.

• Structural Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Nancy C. Horton is a Professor in the Department of Molecular and Cellular Biology at the University of Arizona, with joint faculty appointments in Biochemistry. Her research focuses on understanding the structures and mechanisms of proteins involved in DNA and RNA processing, particularly enzymes that modulate their activity through filament formation. She leads the Horton Lab, which employs structural techniques like X-ray crystallography, NMR, and cryo-electron microscopy alongside biochemical and high-throughput methods. Dr. Horton received her B.S. in Chemistry from Southern Illinois University (1986) and Ph.D. in Biological Chemistry from the University of Pennsylvania (1994). She completed postdoctoral training at The Upjohn Company and the University of California, Santa Barbara, before establishing her independent lab at the University of Arizona in 2001. Her work has contributed significantly to understanding enzyme filamentation in cellular defense mechanisms and host-virus interactions, particularly with Human Parvovirus B19. Research interests include structural biology, biophysics, and the functional implications of protein filaments. Her lab has elucidated the structural basis of enzyme activation via filamentation and its role in DNA cleavage specificity. She also engages in education initiatives, teaching courses on the molecular basis of life and professional development for graduate students. Key contributions include the discovery of enzyme filamentation as a regulatory mechanism and structural studies of SgrAI and NS1 proteins. The lab collaborates broadly, leveraging multi-scale modeling and experimental approaches to study macromolecular complexes. Dr. Horton’s work bridges basic science and translational research, with implications for antiviral drug development and understanding fundamental biological processes.

Daniel Nettelsمشاهده پروفایل

پژوهشگر

• Biophysics
• Single-molecule spectroscopy
• Protein folding and misfolding
• +۳ مورد دیگر

Dr. Daniel Nettels is a Senior Scientist at the University of Zurich's Department of Biochemistry within the Faculty of Science. His research focuses on biophysical methods, including single-molecule spectroscopy and fluorescence techniques, to study protein folding, misfolding, and the dynamics of biomolecular condensates. He joined Prof. Ben Schuler's group in 2004 after completing a Ph.D. in physics at the University of Fribourg and prior studies in physics at the University of Bonn. Nettels teaches the module BCH 306: Biochemical and Biophysical Methods. His work integrates experimental and computational approaches to understand disordered proteins and their roles in biological systems. Education: Ph.D. in Physics, University of Fribourg (2003) M.Sc./Diploma in Physics, University of Bonn (1998) Research Interests: Single-molecule FRET and spectroscopy Biomolecular condensates and their dynamics Intrinsically disordered proteins Teaching: BCH 306 module in the Faculty of Science

Belinda Abbottمشاهده پروفایل

دانشیار مدعو

• Medicinal Chemistry
• Organic Chemistry
• Biological Chemistry
• +۷ مورد دیگر

Dr. Belinda Abbott is an Adjunct Associate Professor at La Trobe University's Department of Chemistry and Physics, affiliated with the La Trobe Institute of Molecular Science. She specializes in medicinal chemistry and synthetic organic chemistry, focusing on small molecule inhibitors for bacterial enzymes, malaria treatment, and neurodegenerative diseases. Current projects: Fragment-based drug design for antibacterial agents, cardiac arrhythmia therapies, and PKA inhibition in malaria Key collaborations: Australian Research Council-funded initiatives Research Focus: Her work spans Medicinal Chemistry , Organic Chemistry , and Biological Chemistry , emphasizing structure-activity relationships and lysine biosynthesis inhibition. Recent publications highlight advances in dual-target herbicides, allosteric enzyme inhibition, and antimalarial compounds. Professional Activities: Member of the Royal Australian Chemical Institute since 2007. Grant recipient for NMR infrastructure and peptide nucleic acid research (2007-2022). Teaching: Coordinates and teaches undergraduate/postgraduate courses in organic chemistry, medicinal chemistry, and honors chemistry programs.

• Biosensors
• Point-of-care diagnostics
• CRISPR technology
• +۱۰ مورد دیگر

Hongquan Zhang serves as an Associate Professor in the Department of Laboratory Medicine & Pathology at the Faculty of Medicine & Dentistry, University of Alberta. His research program develops cutting-edge bioanalytical tools for ultrasensitive and point-of-care detection of biological targets, with a particular focus on infectious disease diagnostics. Education: Ph.D., University of Alberta (2009) M.Sc., Northwest University, Xi'an, China (1999) B.Sc., Northwest University, Xi'an, China (1997) Dr. Zhang's research explores binding-induced DNA assembly to create innovative diagnostic platforms. His laboratory specializes in developing fluorescent nanosensors for real-time detection in cellular environments, constructing target-triggered DNA nanomachines, and engineering novel affinity ligands through manipulation of functional nucleic acids. His work has made significant contributions to CRISPR-based diagnostics, particularly for SARS-CoV-2 detection, where his team has developed multiple point-of-care testing approaches that integrate nucleic acid amplification with CRISPR technology. Analysis of Dr. Zhang's recent publications reveals a strong research trajectory focused on integrating DNA nanotechnology with CRISPR systems to create streamlined diagnostic platforms. His work consistently addresses the challenge of moving complex molecular diagnostics from laboratory settings to point-of-care applications, with particular emphasis on sample preparation, signal amplification, and visual readout systems that eliminate the need for sophisticated equipment. The interdisciplinary nature of his research bridges chemistry, molecular biology, nanotechnology, and clinical medicine. Teaching: LABMP 551: Laboratory Research Methods LABMP 552: NSERC CREATE Course

• Synthetic Organic Chemistry
• Photochemistry
• Bioorganic Chemistry
• +۵ مورد دیگر

David Aitken is a Professor of Organic Chemistry at the Institute of Molecular Chemistry and Materials of Orsay (ICMMO - UMR 8182) , University of Paris-Saclay. His research focuses on synthetic methodology , photochemistry , and the preparation of bioactive molecular scaffolds . He studied Chemistry at the University of Strathclyde (BSc 1983, PhD 1986), followed by a CNRS Researcher position at the University of Paris 5 before becoming a Professor at the University of Clermont-Ferrand 2 in 1998. Since 2006, he has led his research group at Orsay and currently serves as Director of ICMMO . Education : BSc and PhD in Chemistry (University of Strathclyde, Scotland) Research Interests : Synthetic methodology, photochemical transformations, hydrogen bonding in peptides, conformational control, and biologically relevant molecules Methodologies : Photochemistry, organocatalysis, tandem reactions, stereoselective synthesis, and computational modeling Structural Analysis : Hydrogen bonding, helical folding, and non-covalent interactions using spectroscopy and molecular modeling Current Role : Director of ICMMO research institute His recent publications highlight innovations in peptide helical folding , cyclobutane and cyclopropane synthesis , and enantioselective catalytic reactions . His work bridges organic synthesis with biological applications, particularly in protein interaction inhibitors and insulin-sensitizing molecules .