جست‌وجوی استاد و پژوهشگر

Rafael Pinilla Redondoمشاهده پروفایل

استادیار

• Bacterial Immunity
• CRISPR-Cas Systems
• Molecular Evolution
• +۴ مورد دیگر

Rafael Pinilla-Redondo is an Assistant Professor in the Department of Biology at the University of Copenhagen's Faculty of Science, where he leads the Bacterial Immunity research group within the Section of Microbiology. His laboratory, located at Universitetsparken 15 in Copenhagen, focuses on the molecular mechanisms of bacterial defense systems against phages. His research interests center on bacterial immunity, particularly how CRISPR-Cas and other bacterial immune systems evolve and function. He investigates the molecular mechanisms driving these complex systems to answer fundamental biological questions and develop novel biotechnologies. His work spans phage biology, molecular evolution, molecular biology, and genetics, with a specific emphasis on bacterial defense mechanisms against viral threats. Dr. Pinilla-Redondo's recent publications demonstrate significant contributions to understanding bacterial immune systems, particularly CRISPR-Cas variants, retrons, and other defense mechanisms. His research shows strong trends in structural biology approaches to understanding immune system function, with increasing focus on the supramolecular organization of defense complexes and their evolutionary implications. Villum Young Investigator grant (2023) His laboratory maintains active collaborations across multiple institutions, as evidenced by the international authorship on his publications. The lab has developed specialized software tools including CRISPR-Cas Typer for automated identification of CRISPR-Cas loci, Plasmid Network for exploring the global plasmidome, and Hoodini (coming soon) for genome neighborhood visualization. His work has received significant attention, with multiple papers picked up by news outlets, blogged about, and widely shared on social media platforms. The Pinilla-Redondo Lab is part of the vibrant microbiology research community at the University of Copenhagen, focusing on the evolutionary arms race between bacteria and their viral predators.

• Bacterial Immunity
• CRISPR-Cas Systems
• Molecular Microbiology
• +۳ مورد دیگر

Mario Rodríguez Mestre is a Research Fellow in the Department of Biology specializing in Microbiology at the University of Copenhagen. His research focuses on elucidating molecular mechanisms of bacterial immunity against viral infections and genetic elements. His primary research interests include: CRISPR-Cas systems and their evolutionary adaptations Reverse transcriptase-mediated defense mechanisms Nucleotide-based signaling in bacterial immune responses Bacteriophage resistance pathways Noncoding RNA regulation of bacterial immunity Prokaryotic defense system diversity Dr. Mestre's recent publications (2022-2025) demonstrate an impressive trajectory in understanding bacterial defense systems, with work appearing in premier journals including Science, Nucleic Acids Research, and Molecular Cell. His research particularly advances knowledge of type IV and type VI CRISPR-Cas systems, retrons, and the UG/Abi family of reverse transcriptases, revealing novel mechanisms of bacterial self-defense. His collaborative work has garnered significant attention across academic and public spheres, with multiple publications covered by news outlets and widely shared across social media platforms, indicating the broad relevance and impact of his research contributions to microbial immunity.

• Inflammatory Bowel Diseases
• Ulcerative Colitis
• Crohn's Disease
• +۷ مورد دیگر

Lene Buhl Riis serves as a Clinical Associate Professor in the Department of Clinical Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. Her clinical affiliation is with Copenhagen University Hospital (Region Hovedstaden), as indicated by her email domain regionh.dk. She specializes in pathology with a specific focus on gastrointestinal diseases and inflammatory conditions. Dr. Riis's research program centers on inflammatory bowel diseases, with particular emphasis on ulcerative colitis and Crohn's disease. Her work investigates biomarkers for disease progression, intestinal fibrosis mechanisms, and molecular pathways involved in gastrointestinal inflammation. She has made significant contributions to understanding how histological features predict clinical outcomes and how collagen remodeling relates to intestinal complications in inflammatory bowel disease. Analysis of her recent publications reveals a strong translational research focus, bridging laboratory findings with clinical applications. Her work on JAK/STAT signaling pathways, extracellular matrix products, and noncoding RNAs as biomarkers demonstrates innovative approaches to understanding disease mechanisms and developing diagnostic tools for inflammatory bowel diseases. Dr. Riis maintains an extensive collaborative network across multiple research institutions, contributing to high-impact publications in leading gastroenterology journals including Inflammatory Bowel Diseases, Journal of Crohn's and Colitis, and Stem Cell Reports. Her research has practical clinical applications for improving diagnosis, monitoring, and treatment strategies for patients with inflammatory bowel diseases.

Jan-Wilhelm Kornfeldمشاهده پروفایل

استاد

• Noncoding RNAs
• Energy Metabolism
• Obesity
• +۳ مورد دیگر

Jan-Wilhelm Kornfeld is Professor of Molecular Biology of Metabolic Disease at the University of Southern Denmark's Department of Biochemistry and Molecular Biology. He co-founded the ADIPOSIGN research center and leads investigations into noncoding RNA regulation of metabolic pathways, focusing on obesity and type 2 diabetes. His laboratory employs transgenic mouse models, next-generation sequencing, and in vivo RNA targeting to study how microRNAs and long noncoding RNAs control energy homeostasis. Current projects examine adipose tissue plasticity, intergenerational epigenetic inheritance of metabolic dysfunction, and RNA-based therapeutics. Key research themes include: Noncoding RNA regulation of glucose/lipid metabolism Adipose tissue remodeling in obesity Cold-induced thermogenesis Paternal epigenetic inheritance Major publications appear in Nature Metabolism, Nature Communications, and Cell Reports. His research has been recognized with an Emmy-Noether Programme Grant (2014) and ERC Starting Grant (2016). He directs the Kornfeld Lab, supervising PhD candidates and research staff in functional genomics approaches.

Robin Anderssonمشاهده پروفایل

دانشیار

• Transcriptional regulation
• Enhancers
• Promoters
• +۴ مورد دیگر

Robin Andersson is an Associate Professor at the Department of Biology, University of Copenhagen , leading the Andersson Lab focused on modeling gene regulation to understand how enhancer and promoter dysregulation contribute to disease risk. His interdisciplinary research combines machine learning , statistical learning , genetics , and molecular biology to determine which noncoding sequences act as enhancers, predict regulatory activity from DNA sequences, and characterize mechanisms controlling gene expression variation. His research has produced significant insights into enhancer-promoter interactions , epigenetic inheritance , and transcriptional robustness . He has developed computational tools like ChromTransfer and hyperTRIBER for analyzing chromatin accessibility and RNA editing . His work bridges genomic mechanisms of disease with practical applications in noncoding variant interpretation and therapeutic target identification . Robin Andersson has received prestigious awards including the ERC Horizon 2020 Starting Grant , Sapere Aude Research Leader award , and Hallas-Møller Ascending Investigator award . He has supervised 17 MSc and 5 PhD students while contributing to academic service as PhD coordinator and strategic research board member. The lab maintains affiliations with the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease and FANTOM consortium , with recent grants focusing on single-cell regulatory mapping and disease variant interpretation .

• Cytogenetics
• Translocations and inversions
• Next generation sequencing
• +۷ مورد دیگر

Niels Tommerup is a Professor of Medical Genetics at the Department of Cellular and Molecular Medicine, University of Copenhagen, where he has served since 1996. He previously directed the Wilhelm Johannsen Centre for Functional Genome Research (2001-2013) and was Deputy Head of Department (2007-2019). His research group focuses on mapping balanced chromosomal rearrangements (BCR) to identify disease genes, regulatory domains (Topological Associating Domains), and novel genetic mechanisms, as well as characterizing germline chromothripsis and functional studies of non-coding RNA genes. Tommerup earned his DMSc. in genetics (1994) and medical degree (Cand.med., 1978) from the University of Copenhagen. His early career included positions as a junior doctor, research assistant, and senior doctor at the J.F. Kennedy Institute in Denmark (1978-89), and as a Consultant at the Department of Medical Genetics, Ullevål University Hospital in Oslo, Norway (1989-91). He has held visiting scientist positions at institutions in London, Australia, and Norway. His research spans multiple areas including cytogenetics, translocations and inversions, next generation sequencing, Topological Associating Domains, Long Range Position Effects, 3D-genome organization, and long noncoding RNAs. Tommerup coordinates the International Breakpoint Mapping Consortium (2014-present), involving over 100 diagnostic cytogenetic laboratories from more than 50 countries across six continents. His work has established that direct gene truncation may explain approximately 18% of BCR-associated developmental disorders, and that long-range position effects may be at least as frequent a cause as gene truncation. His recent publications reveal trends in understanding sex differential responses to viral infections (particularly focusing on the X-chromosome), linking anatomical variation to genetic variation, and developing methods for visualization of nuclear genome organization. His work bridges basic genomic research with clinical applications in developmental disorders, intellectual disability, autism, epilepsy, and other conditions. Det Classenske Fideicommis Boglegat (1987) Iris Preuss's Mindelegat (1994) First Harold Klinger Memmorial Award Lecture, Atlanta, USA (2006) Tommerup has supervised 27 PhD students and 10 postdocs. His editorial roles include service on the boards of Briefings in Functional Genomics, Clinical Genetics, Computational and Structural Biotechnology Journal, PeerJ, and Australasian Med J. He has organized numerous academic events including the International Summer School in Functional Genomics and the Wilhelm Johannsen Symposium. His international collaborations include the EU-concerted action Mendelian Cytogenetics Network and the International Breakpoint Mapping Consortium. Tommerup leads the Tommerup Group which coordinates the International Breakpoint Mapping Consortium and collaborates with Michael Talkowski's group at Harvard to accumulate the largest collection of sequence-resolved germline balanced chromosomal rearrangements. His laboratory combines DNA-DNA-interaction (Hi-C) studies with short and long read sequencing to improve the dissection of complex chromosomal rearrangements. The group has initiated systematic X-inactivation studies of sequence-resolved X;autosomal translocations and X-inversions, and conducts research on germline chromothripsis and host genetic factors underlying sex differential responses to viral infections.

• RNA Modifications
• Noncoding RNA Biology
• Cancer Epigenetics
• +۴ مورد دیگر

Sarah Rennie serves as Assistant Professor in the Department of Biology within the Faculty of Science at the University of Copenhagen, specializing in Computational and RNA Biology. Her research focuses on RNA modifications and their implications in cancer biology, particularly gastrointestinal and pancreatic cancers. Her primary research interests span RNA modifications, noncoding RNA biology, cancer epigenetics, and bioinformatics. Current work investigates N6-methyladenosine (m6A) modifications in pancreatic cancer progression, tumor microenvironment adaptations, and computational approaches for RNA analysis. Her lab develops and benchmarks bioinformatic tools for lncRNA research and RNA editing detection, bridging wet-lab experiments with computational modeling. Recent publications demonstrate significant contributions to understanding RNA modification roles in cancer, with 2024-2025 work appearing in high-impact journals including Cancer Science , Cell Reports , and EMBO Journal . Her research shows strong emphasis on translational applications, particularly in developing RNA-based cancer biomarkers and therapeutic targets. Rennie serves as Editor for the journal Non-coding RNA (2023), demonstrating leadership in the field. Her work receives consistent attention across academic platforms with multiple mentions on X (formerly Twitter), Reddit, Bluesky, and Mendeley. Her laboratory operates within the Computational and RNA Biology section at Ole Maaløes Vej 5 in Copenhagen, utilizing both experimental and computational approaches to study RNA modifications in disease contexts. Current projects focus on acid microenvironment adaptations in pancreatic cancer and deep learning applications for RNA modification analysis.

• Inflammatory Bowel Disease
• Gastroenterology
• Hepatology
• +۳ مورد دیگر

Ebbe Langholz serves as a Clinical Associate Professor and Chief Physician (DMSc) at the University of Copenhagen's Department of Clinical Medicine, specializing in Gastroenterology and Hepatology. Based at Copenhagen University Hospital (Region Hovedstaden), he maintains dual academic-clinical roles focused on inflammatory bowel disease (IBD) research and patient care. His institutional affiliation includes the section for Internal Medicine: Gastroenterology and Hepatology, with operational bases in Herlev and Copenhagen N. Langholz's research program centers on IBD epidemiology in Nordic populations, particularly through landmark studies of the Faroese cohort. His work spans disease incidence/prevalence trends, mortality analysis, environmental risk factor identification, health-related quality of life assessments, and molecular biomarker discovery. Notably, he integrates clinical epidemiology with translational approaches—examining tissue-specific TNF mRNA for anti-TNF therapy optimization and noncoding RNAs for disease classification. His focus on isolated populations like the Faroe Islands provides unique insights into IBD pathogenesis unattainable in heterogeneous settings. Analysis of his 2023-2025 publications reveals a cohesive trajectory: leveraging large-scale cohort studies (1960-2020) to address clinical challenges in IBD management. Key themes include cross-cultural comparisons between Danish and Faroese patients, therapeutic applications of biologics like mirikizumab, and biomarker-driven treatment personalization. This work consistently appears in high-impact gastroenterology journals, reflecting methodological rigor and clinical relevance. While no formal awards are documented in the provided materials, his research has been referenced in clinical guideline sources and demonstrates significant academic engagement through citations and Mendeley readership. Collaborative networks with researchers like P. Munkholm and J. Burisch underscore his role in Denmark's gastroenterology research ecosystem. Langholz operates within Copenhagen University Hospital's clinical infrastructure, facilitating direct translation of research findings into practice. His work involves multi-center collaborations across Danish regions and the Faroe Islands, utilizing population registries and biobanks to advance IBD understanding. Current projects suggest continued emphasis on predictive diagnostics and tailored therapeutic strategies for complex IBD cases.