جست‌وجوی استاد و پژوهشگر

Lars Aagaardمشاهده پروفایل

دانشیار

• Gene therapy
• RNA interference
• Viral vectors
• +۱۱ مورد دیگر

Lars Aagaard is an Associate Professor at the Department of Biomedicine - Research and Education, Aarhus University, Denmark. He is based at the Bartholin Building in Aarhus C and is actively engaged in research and teaching in the fields of gene therapy, RNA interference, and genome editing. His work focuses on developing viral vectors, particularly AAV and lentiviral vectors, for ocular gene therapy targeting retinal diseases such as age-related macular degeneration and diabetic retinopathy. His research interests include the development of Dicer-independent RNAi systems, combinatorial gene therapy using microRNA and CRISPR/Cas9, and the delivery of RNA- and protein-based therapeutics. He also teaches Genetics and Personalized Medicine and supervises postdoctoral researchers, PhD, master's, and undergraduate students. The recent publications (2022–2024) reflect a strong trend in RNAi therapeutics, viral vector engineering, and translational applications in ocular and systemic diseases. Themes include gene silencing, immune modulation, and regenerative approaches using engineered cells. Aagaard actively contributes to the scientific community as a reviewer for journals such as Nature and Molecular Therapy . He has participated in key international conferences including ARVO, ASGCT, and ESGCT, demonstrating ongoing engagement with the global gene therapy community. Supervision of postdocs, PhD, master’s, and undergraduate students Active participation in international conferences and workshops Collaborative research across institutions, including Universidade Federal de Sao Paulo He is involved in both basic and translational research, with potential for clinical applications in gene and cell therapy.

Emma Denhamمشاهده پروفایل

مدرس ارشد

• Microbiology
• Bacterial Genetics
• Non-coding RNA Regulation
• +۳ مورد دیگر

Emma Denham is a Senior Lecturer in Microbiology at the University of Bath's Department of Biology and Biochemistry, part of the Centre for Climate Adaptation & Environment Research (CAER). She transitioned to Bath in 2018 from the University of Warwick, where she served as an Assistant Professor. Her research focuses on non-coding RNAs in Bacillus subtilis , exploring their roles in post-transcriptional regulation, biofilm formation, antimicrobial resistance, and metabolic pathways. She investigates how small RNAs (sRNAs) and antisense RNAs modulate bacterial behavior under environmental stress. Education & Career: BSc Biology, University of Leicester PhD in Microbiology, Pirbright Institute (formerly Institute for Animal Health) Postdoctoral Research, Jan Maarten van Dijl's lab (EU consortia on systems/synthetic biology) Research Interests: Emma's lab studies regulatory RNAs' impact on B. subtilis behavior, including biofilm formation, competence, and antibiotic resistance. Notable projects include identifying novel sRNA mechanisms distinct from Gram-negative systems and exploring RNA sponges that regulate the RoxS riboregulator. Collaborative efforts include applying bacterial systems to develop zero-carbon concrete via Engineering and Physical Sciences Research Council (EPSRC) grants (2023). Recent Work Trends: Recent articles highlight mechanisms of bacterial resistance to antiseptics, transcriptome annotation via Rend-seq, and RNA-sponge-mediated regulation. These studies bridge basic microbiology with applied challenges like biocide resistance and sustainable materials. Grants & Collaborations: EPSRC IAA Project: Bacteria-based zero carbon concrete (2023) EU consortia during postdoctoral work Labs & Teams: Leads a microbiology lab at Bath, focusing on interdisciplinary projects combining genomics, systems biology, and synthetic approaches to understand bacterial adaptation and regulatory networks.

Coleen T. Murphyمشاهده پروفایل

استاد

• Aging
• Molecular Biology
• Genetics & Genomics
• +۷ مورد دیگر

Coleen T. Murphy is the James A. Elkins Jr. Professor in the Life Sciences and Professor of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics at Princeton University. She serves as Director of the Lewis-Sigler Institute and Director of the Paul F. Glenn Laboratories for Aging Research, highlighting her leadership in aging and genomics research. Her work bridges molecular biology, genetics, and computational approaches to understand aging and age-related decline. Her research focuses on the molecular mechanisms of aging, particularly using the nematode C. elegans as a model organism. Key interests include longevity pathways, insulin/IGF-1 signaling, reproductive aging, neurodegenerative diseases, transgenerational inheritance, and mitochondrial function. Her lab integrates genomic, transcriptomic, and functional screening techniques to identify genes and pathways that regulate aging and healthspan. The recent publications of her lab demonstrate a strong trend in interdisciplinary research combining genetics, neuroscience, and computational biology. Themes include cognitive aging, learned behavior, pathogen avoidance, metabolic regulation, and drug discovery in neurodegenerative models. Her work increasingly employs high-throughput methods and cross-omics analysis to uncover conserved mechanisms relevant to human health. HHMI Faculty Scholar, Howard Hughes Medical Institute (2016) Pioneer Award, National Institutes of Health (2015) Innovation Award, Department of Molecular Biology, Princeton University (2014) Glenn Foundation for Medical Research Award (2012) Dr. Murphy leads a vibrant research group and mentors numerous students and postdoctoral researchers. Her lab has secured significant funding from HHMI, NIH, and the Glenn Foundation, supporting innovative projects in aging and longevity. She also directs major research initiatives, including the Simons Foundation’s SCPAB (Plasticity and the Aging Brain), underscoring her national leadership. The Murphy Lab at Princeton is a multidisciplinary team employing C. elegans to study aging, cognitive decline, and intergenerational signaling. The lab utilizes cutting-edge tools including microfluidics (e.g., CeLab), transcriptomics, and behavioral assays. It is part of the Department of Molecular Biology and the Lewis-Sigler Institute, fostering collaboration across genomics, neuroscience, and computational biology.

Ritwick Sawarkarمشاهده پروفایل

عضو هیئت علمی

• Chromatin Biology
• Environmental Stress Response
• Transcriptional Regulation
• +۳ مورد دیگر

Ritwick Sawarkar is a Principal Investigator at the MRC Toxicology Unit and affiliated with the Department of Genetics under the School of Biological Sciences at the University of Cambridge. He leads the Sawarkar Group, focusing on molecular mechanisms linking chromatin biology, environmental stress response, and transcriptional regulation. Education: PhD in Genetics (Indian Institute of Science, 2010) Previous roles: Postdoctoral Fellow at ETH-Zürich (2010-2014), Independent Group Leader at Max Planck Institute (2014-2019) Research Interests : The Sawarkar Group investigates how chromatin interprets environmental stress signals to modulate transcriptional responses. Key questions include: (i) Cellular pathways sensing stress/toxins, (ii) Chromatin's role in stress adaptation, and (iii) Transcriptional mechanisms for cellular survival. Their work integrates genomics, single-cell transcriptomics, proteomics, and mouse models to explore stress response pathways. Article Trends : Recent publications highlight his expertise in chromatin-mediated stress responses, non-coding RNA interactions, and proteostasis networks. Collaborations with pharmaceutical companies emphasize translational applications for drug toxicology and RNA therapeutics. Scientific Awards : ERC Consolidator Grant (2018) Alfred Tissières Young Investigator Award (2019) Group Members : His team includes PhD students (Dimitris Aspri, Roberto Campalastri), Research Associates (Simone Baldan, Christo Christov), and MPhil students (Anfas Muhammed, Keely Xia), among others.

Stephen A. Krawetzمشاهده پروفایل

استاد

• Molecular Genetics
• Epigenetics
• Reproductive Biology
• +۵ مورد دیگر

Stephen A. Krawetz is a Professor at Wayne State University with dual appointments in the Departments of Obstetrics and Gynecology and Molecular Medicine and Genetics . He serves as the Charlotte B. Failing Professor of Fetal Therapy and Diagnosis and Associate Director of the C.S. Mott Center for Human Growth and Development .

• Systems Biology
• Genomics
• Post-transcriptional Gene Regulation
• +۳ مورد دیگر

CHEN Wei is a Chair Professor at the Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech), Shenzhen, China. He holds a Ph.D. from the Max Planck Institute for Molecular Genetics (2006) and previously served as a Full Professor (W3) at the Max-Delbrück Center for Molecular Medicine and Charité – Universitätsmedizin Berlin (2015-2016). Prior to joining SUSTech, he led research groups at prestigious German institutions, contributing to large-scale genome centers and the Berlin Institute of Health. Education : Ph.D. (2006, Max Planck Institute), M.S. (2002, Sichuan University), B.S. (1993, Xiamen University) His research focuses on systems biology and genomics, particularly post-transcriptional gene regulation mechanisms and their roles in human diseases. His lab integrates next-generation sequencing technologies with computational approaches to study non-coding RNA functions, alternative splicing, and chromatin dynamics. Key projects include CRISPR-based functional studies, 3D genome analysis, and RNA editing in neurological and metabolic disorders. Recent publications highlight his work in Drosophila developmental genomics, chloroplast translation control, and cancer biology. The 2025 study on spatiotemporal multi-omics in Drosophila and 2024 articles on MatK's role in tRNA splicing and CRISPR-activated transcriptional regulation exemplify his interdisciplinary approach. Earlier works (2023-2022) address immune cell trafficking, alternative polyadenylation, and chromatin remodeling in cancer metastasis. At SUSTech, he leads a team with 4 research assistant professors, 2 postdoctoral fellows, 3 research assistants, and 7 graduate students. His lab has secured significant funding from EU and German agencies (€7M+), though specific awards are not detailed in the provided text. Teaching responsibilities include General Biology and Principles of Cell Biology.

ANDREA KASINSKIمشاهده پروفایل

استاد

• Non-coding RNA biology
• MicroRNA therapeutics
• Cancer epigenetics
• +۳ مورد دیگر

Andrea Kasinski is a Professor of Biological Sciences and Deputy Director of the Purdue Institute for Cancer Research at Purdue University. Her research focuses on non-coding RNAs (microRNAs, lncRNAs, circRNAs) in cancer development and their therapeutic applications. She leads a multidisciplinary team investigating RNA delivery systems, extracellular vesicle biology, and epigenetic regulation in cancer. Key projects include ligand-mediated delivery of miRNAs, exosome-based therapies, and high-throughput screens for miRNA inhibitors. Education: PhD in Molecular & Systems Pharmacology (Emory University, 2009), Postdoctoral Fellowship in Genetics (Yale University, 2013). Awards include NIH Pathway to Independence Award (2013), American Cancer Society Research Scholar (2017), and multiple grants from NIH/NCI (R01 CA205420, R01 CA226259). Her lab has pioneered 'FolamiRs' – folate-targeted miRNA therapeutics – and developed novel strategies for endosomal escape of RNA payloads. Major contributions include identifying miRNA drivers of drug resistance, demonstrating exosome-mediated tumor progression, and advancing miR-34a as a clinical candidate. The lab maintains active collaborations with institutions including Harvard Medical School, MD Anderson Cancer Center, and the National Cancer Institute. Current initiatives focus on KMT5C-mediated epigenetic regulation in EGFR-resistant lung cancers and translational development of fully modified miR-34a (FM-miR-34a).

Rachel O'Neillمشاهده پروفایل

استاد

• Genome Stability
• Retroelement Transcription
• Centromere Function
• +۵ مورد دیگر

Rachel O'Neill serves as a Board of Trustees Distinguished Professor in the Department of Molecular and Cell Biology at the University of Connecticut's College of Liberal Arts and Sciences. Her research bridges molecular genetics, cytogenetics, and computational genomics to investigate fundamental mechanisms of genome stability and evolution across diverse eukaryotic species. Her primary research interests focus on retroelement transcription, centromere function, chromosome evolution, and species-specific genomic adaptations. O'Neill's lab pioneers telomere-to-telomere (T2T) genome assembly methodologies using next-generation sequencing technologies, establishing non-traditional model organisms including marsupials, monotremes, birds, marine species, plants, and insects for comparative genome biology studies. Human Telomere-to-Telomere Consortium Primate T2T Consortium Gibbon T2T Consortium Earth Biogenomes Project Ruminant T2T Consortium Fly T2T Consortium Deep Ocean Genomes Project Antarctic Genomes Consortium Colossal Foundation UConn’s Biodiversity and Conservation Genomics program O'Neill's recent publications (2021-2025) demonstrate leadership in large-scale genomics initiatives, with significant contributions to understanding centromere biology, sex chromosome evolution, and conservation genomics. Her work spans marsupial mole genomics, ruminant chromosome evolution, and epigenetic regulation of X-chromosome inactivation, reflecting her lab's broad impact across evolutionary biology, conservation, and fundamental genome science. Her laboratory actively trains students through cohort-based programs including the RaMP Cohort and Biodiversity and Conservation Genomics Program, securing substantial collaborative funding through multi-institutional consortia. The lab maintains strong infrastructure for advanced genome assembly and epigenomic analysis, with particular expertise in challenging repetitive regions and non-model organism genomics.

Heike Krebberمشاهده پروفایل

استاد

• mRNA Quality Control
• ncRNA Functions
• Molecular Biology
• +۳ مورد دیگر

Prof. Heike Krebber is a Professor for Molecular Genetics at Georg-August University Göttingen, Germany. Her research focuses on mRNA quality control and non-coding RNA functions, using the model organism Saccharomyces cerevisiae. She has held positions at the DKFZ (Heidelberg), Harvard Medical School, and Philipps-Universität Marburg. Her work addresses how mRNA processing defects contribute to diseases like cancer and neurodegeneration. Education & Positions: PhD (1996), Deutsches Krebsforschungszentrum Heisenberg Fellow (2006) Habilitation in Molecular Biology (2005) Professor since 2010 at Georg-August University Research Interests: Her lab investigates: RNA quality control mechanisms ensuring proper mRNA maturation and export Functions of non-coding RNAs (e.g., lncRNAs in iron metabolism and telomerase) Ribosome assembly and translation termination pathways Stress-induced bypass of mRNA quality control Awards: Heisenberg Fellowship (2006) Grants & Teams: Leads the Molecular Genetics group at the Institute for Microbiology and Genetics. Collaborates with the IMPRS Molecular Biology and GZMB (Molecular Biology of Cells) programs. Labs & Affiliations: Her group is part of the GGNB network, focusing on Microbiology and Biochemistry. The lab’s work spans fundamental molecular mechanisms with translational disease relevance.

Ole Nørregaard Jensenمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Posttranslational Modification
• +۹ مورد دیگر

Ole Nørregaard Jensen is a Professor in Biomedical Mass Spectrometry and Systems Biology at the Department of Biochemistry and Molecular Biology, University of Southern Denmark . His research integrates advanced mass spectrometry, proteomics, and bioinformatics to study chromatin biology, post-translational modifications, and cellular signaling networks. He is actively involved in major research initiatives funded by Novo Nordisk Foundation and Lundbeck Foundation. His research interests include Mass Spectrometry, Proteomics, Posttranslational Modification, Histone Biology, Chromatin Biology, Bioinformatics, Systems Biology, Lipidomics, and Protein Chemistry . He employs cutting-edge techniques such as tandem mass spectrometry and ion mobility spectrometry to analyze protein isomers and dynamic modifications. His work has significant implications for understanding gene regulation, DNA replication, and disease mechanisms. His recent publications demonstrate a strong trend in chromatin dynamics, epigenetics, and integrated omics approaches , combining proteomics with transcriptomics and lipidomics to unravel complex biological systems. His research spans from fundamental molecular mechanisms to translational applications in biomedicine and food science. He has been recognized with several prestigious awards: MCP Lectureship Award Juan Pablo Albar Proteomics Pioneer Award 2019 EliteForsk 2009 prize Knight Order of Dannebrog (Ridder af Dannebrogordenen) Jensen is deeply involved in academic service, including peer review for journals like Nature Communications and Molecular and Cellular Proteomics , organizing conferences, and supervising students. He teaches courses such as Biomedical Mass Spectrometry - Principles and Applications and coordinates the Computational Biomedicine international Master’s program. He leads multiple active research projects, including PLATO and INTEGRA, focusing on health data, imaging, and protein networks. He is a key member of a vibrant research environment in biomedical mass spectrometry at SDU, contributing to both national and international scientific collaborations. His lab is at the forefront of developing and applying novel mass spectrometry methodologies for systems biology.

• Bioinformatics
• Computational Biology
• Protein Informatics
• +۳ مورد دیگر

Barış Ethem Süzek is an Associate Professor in the Department of Computer Engineering at the Faculty of Engineering, Muğla Sitki Koçman University. His academic career spans institutions including Middle East Technical University (BS), Johns Hopkins University (MS), and George Mason University (PhD) in Computational Biology. He specializes in bioinformatics and computational biology, focusing on protein informatics, genetic analysis, and machine learning applications in medical research. Education BS: Middle East Technical University - Computer Engineering (1997) MS: Johns Hopkins University - Computer Science (2000) PhD: George Mason University - Computational Biology (2012) His research integrates bioinformatics with molecular dynamics, particularly in host-pathogen interactions, regenerative medicine, and genomic data analysis. He has developed machine learning tools for viral interaction prediction and variant analysis systems. His work with UniProt and cancer Biomedical Informatics Grid projects demonstrates expertise in large-scale biological data integration. Scientific awards include Collaboration, Outstanding Achievement, and Change Agent Awards from the cancer Biomedical Informatics Grid, plus multiple patent recognitions for biomedical systems. He has supervised numerous graduate students in bioinformatics, computational genetics, and forensic biology projects.

Anne Ferguson-Smithمشاهده پروفایل

استاد

• Genomic Imprinting
• Epigenetics
• Developmental Genetics
• +۳ مورد دیگر

Professor Anne Ferguson-Smith is a leading mammalian developmental geneticist and epigeneticist at the University of Cambridge, holding the Arthur Balfour Professorship of Genetics. As Pro-Vice-Chancellor for Research, she oversees the university's research strategy while maintaining her laboratory's focus on genomic imprinting and epigenetic inheritance . Her work bridges experimental and computational approaches through affiliations with the Cambridge Stem Cell Institute, Cambridge Neuroscience, and the Centre for Trophoblast Research. Research in her lab investigates epigenetic mechanisms in developmental processes , particularly through the lens of Dlk1-Dio3 imprinted domain studies. Current themes include: Stem cell epigenetic programming Environmental modulation of epigenetic states Role of repetitive elements in genomic regulation Her group integrates mouse and zebrafish models with high-throughput genomics and mathematical modeling . Key collaborations include: Wellcome Trust UKRI Medical Research Council BBSRC NIH Scientific honors include: Elected EMBO Member (2006) Academy of Medical Sciences (2012) Fellow of the Royal Society (2017) Commander of the Order of the British Empire (CBE) The lab maintains family-friendly research practices and actively participates in interdisciplinary collaborations across Cambridge and internationally.

Adele Murrellمشاهده پروفایل

استاد

• Epigenetics
• Genomic Imprinting
• DNA Methylation
• +۶ مورد دیگر

Professor Adele Murrell is a Professor of Epigenetics in the Department of Life Sciences at the University of Bath's Faculty of Science. She serves as Co-Director of the Centre for Therapeutic Innovation and is affiliated with both the Centre for Mathematical Biology and the Centre for Bioengineering & Biomedical Technologies (CBio). She is currently accepting doctoral students and maintains an active research program with multiple ongoing projects. Her research focuses on understanding how cells establish and maintain their specific identities through epigenetic mechanisms. Her work centers on epigenetic barriers and cell identity, genomic imprinting as a model epigenetic system, long-range epigenetic silencing in cancer, and epigenetic reprogramming during metastasis. She investigates how higher-order chromatin structure and epigenetic modifications shape the genome within the nucleus to constitute cell identity and provide memory of developmental origins. Her current work examines colon cancer and liver metastasis, focusing on changes in DNA methylation and its demethylation intermediates such as 5-hydroxymethylcytosine. Analysis of Professor Murrell's recent publications reveals a strong focus on DNA hydroxymethylation patterns in cancer progression, particularly in colorectal cancer metastasis. Her work bridges molecular epigenetics with clinical applications, exploring how epigenetic changes during metastasis could be targeted to prevent cancer spread. She has developed novel techniques for detecting epigenetic modifications and has made significant contributions to understanding allele-specific chromatin domains and genomic imprinting mechanisms. Professor Murrell leads multiple research projects including 'Two stages of genome wide 5-hydroxymethylcytosine (5hmC) reprogramming during colorectal carcinogenesis and liver metastasis' funded by the MRC until February 2024, and 'Modelling the fits and starts of how genes burst into expression' funded by The Leverhulme Trust until June 2024. She was also a Co-Investigator on the 'Multi User High-Content Confocal Microscope' project funded by the Biotechnology and Biological Sciences Research Council. Her laboratory work connects with UN Sustainable Development Goals, particularly those related to health and well-being. Her fingerprint analysis shows strong activity in Epigenetics (100%), DNA Methylation (94%), Allele research (73%), Methylation studies (69%), Genomic Imprinting (60%), CTCF research (56%), Promoter Region analysis (44%), and Differentially Methylated Regions (34%).

Irene Nobeliمشاهده پروفایل

مدرس ارشد

• Bioinformatics
• Transcriptomics
• Regulatory RNAs
• +۳ مورد دیگر

Dr. Irene Nobeli is a Senior Lecturer and Education Lead (PG taught courses) at the School of Natural Sciences, Birkbeck, University of London. She specializes in computational biology and chemoinformatics, focusing on regulatory RNAs, transcriptomics in health/disease, brain disorders, and small molecule roles in biology. Her work bridges bioinformatics tools development and translational research. Administrative roles include directing the MSc Bioinformatics program and organizing the Sequence Analysis and Omics module. She collaborates with research centers like the Birkbeck Institute for Data Analytics (BIDA) and the Institute of Structural Molecular Biology (ISMB). Research interests span bioinformatics methodologies, Mycobacterium genomics, neurodevelopmental disorders, and computational drug design. Notable contributions include developing flexiMAP (alternative polyadenylation analysis) and baerhunter (bacterial non-coding RNA detection). Publications highlight her expertise in transcriptomics, bacterial pathogenesis, and neurobiological mechanisms. She actively engages in advancing computational methods for genomic data interpretation and translational medicine.

Pilar Blancafortمشاهده پروفایل

دانشیار

• Cancer Biology
• Epigenetics
• Genome Engineering
• +۷ مورد دیگر

Pilar Blancafort is an Associate Professor at The University of Western Australia (UWA), holding positions in the School of Human Sciences and UWA Medical School. She is affiliated with the UWA Centre for Medical Research and collaborates with the Harry Perkins Institute of Medical Research. Her research focuses on epigenetic manipulation in cancer models, particularly breast and ovarian cancers, leveraging CRISPR/Cas9 and genome engineering technologies to develop precision medicine tools. She has co-led projects such as the Lionheart FX Automated High-Content Microscope initiative and actively investigates therapeutic reprogramming of cellular signaling pathways to improve cancer treatment outcomes. Blancafort’s research expertise includes genome engineering, cancer epigenetics, and women’s cancers. She collaborates internationally and has contributed to over 70 publications, 14 datasets, and 43 grants. Her work aligns with UN Sustainable Development Goals, emphasizing global health and innovation in medical research. Key areas of exploration involve reactivating tumor suppressors, silencing oncogenic drivers, and enhancing immune responses through CRISPR-based systems. Her studies on the PI3K-AKT-mTOR pathway and novel oncogenes further underscore her commitment to advancing targeted therapies. Blancafort has supervised 11 students and leads multiple grants, including projects on metastatic breast cancer therapies and ovarian cancer reprogramming. Her lab at the UWA Centre for Medical Research explores translational strategies for epigenome editing in cancer, with a focus on clinical applicability. Recent work highlights lipid nanoparticle delivery systems for CRISPR/dCas9 and synthetic epigenetic approaches to reverse mesenchymal-epithelial transitions in breast cancer.