جست‌وجوی استاد و پژوهشگر

• Neural Engineering
• Electrical Stimulation of the Nervous System
• Deep Brain Stimulation
• +۷ مورد دیگر

Warren M. Grill is the James B. Duke Distinguished Professor and Bass Fellow at Duke University, holding appointments in Neurobiology, Neurosurgery, and Biomedical Engineering. He serves as Core Faculty in Innovation & Entrepreneurship, a Faculty Network Member of the Duke Institute for Brain Sciences, and an Associate of the Duke Initiative for Science & Society. His research employs engineering approaches to understand and control neural function, with a focus on electrical stimulation of the nervous system to restore function in neurological disorders. Ph.D., Case Western Reserve University (1995) M.S., Case Western Reserve University (1992) B.S., Boston University (1989) Dr. Grill's research spans multiple areas of neural engineering and neuromodulation. His work focuses on developing engineering approaches to understand and control neural function, particularly through electrical stimulation of the nervous system. Current projects include deep brain stimulation for movement disorders, peripheral nerve stimulation for bladder function restoration, spinal cord stimulation for chronic pain, transcranial magnetic stimulation, and novel electrode and waveform design. His research integrates computational modeling with experimental approaches to advance bioelectronic medicine. Dr. Grill's recent publications (2023-2025) demonstrate a strong focus on computational modeling of neural stimulation, with particular emphasis on deep brain stimulation, vagus nerve stimulation, and transcranial magnetic stimulation. His work increasingly integrates advanced computational methods with experimental validation across multiple species. There's a clear trend toward developing more selective and efficient stimulation paradigms, understanding cross-species translation of stimulation parameters, and identifying novel therapeutic targets for neurological disorders. Fellow, National Academy of Inventors (2022) Capers & Marion McDonald Award for Excellence in Teaching and Research, Pratt School of Engineering (2018) Javits Neuroscience Investigator Award, NIH-NINDS (2015) Scholar / Teacher of the Year Award, Duke University (2014) Outstanding Postdoc Mentor, Duke University (2013) Fellow, Biomedical Engineering Society (2011) Fellow, American Institute for Medical and Biological Engineering (2007) Dr. Grill has mentored numerous students and postdocs, many of whom have gone on to successful careers in academia and industry. His lab has been consistently supported by major NIH grants, including the Javits Neuroscience Investigator Award from NIH-NINDS. He has also secured funding from various foundations and industry partners to advance his research in neural engineering and bioelectronic medicine. Dr. Grill is known for his collaborative approach, working with clinicians, engineers, and basic scientists across multiple institutions. Dr. Grill leads a vibrant research laboratory at Duke University that combines expertise in neural engineering, computational neuroscience, and experimental neurophysiology. His team includes graduate students, postdoctoral fellows, and research staff working on various aspects of neural stimulation. He is actively involved in the Duke Institute for Brain Sciences and collaborates with members of the Deep Brain Stimulation Think Tank. His lab has developed several innovative computational models and experimental approaches that have significantly advanced the field of neuromodulation.

• Neurodegeneration
• Parkinson's Disease
• Mitochondrial Biology
• +۵ مورد دیگر

Tony Schapira is Professor of Neurological Science at University College London (UCL) and Head of the Department of Clinical Neurosciences at UCL Institute of Neurology. He serves as a Consultant Neurologist at the National Hospital for Neurology and Neurosurgery and Royal Free Hospital, and holds additional leadership positions as Vice Dean of UCL Medical School and Director of the Royal Free Campus. His academic appointments include Visiting Professorships at Harvard (2009) and Yale (2010). Education includes: Bachelor of Science (Honours) from King's College London (1976) Bachelor of Medicine/Bachelor of Surgery from Charing Cross and Westminster Medical School (1979) Member of the Royal College of Physicians (1982) His primary research investigates neurodegeneration mechanisms in Parkinson's disease (PD), with emphasis on mitochondrial dysfunction, alpha-synuclein pathology, and GBA1 mutation pathways. His work spans molecular pathogenesis, drug development for disease modification, and clinical phenotyping of at-risk populations. Current projects focus on identifying prodromal biomarkers and developing neuroprotective therapies through international clinical trials. Schapira's recent publications (2024-2025) demonstrate concentrated research in Parkinson's disease mechanisms, mitochondrial biology, genetic risk factors (particularly GBA1 variants), and novel therapeutic approaches. Article themes consistently explore protein aggregation pathways, lysosomal function, metabolic interactions, and clinical trial methodologies. Awards and honors include: Fellow of the Academy of Medical Sciences (1999) Undergraduate Scholarship at Westminster Medical School He has supervised 11 PhD students and one MD candidate, and currently mentors post-graduate and post-doctoral researchers. His department received UCL's 'Excellence in Medical Education' award (2007-2008). Major grants include co-principal investigator roles on: MRC-Wellcome Strategic Award in Neurodegeneration (£6 million) Wolfson Award (£20 million) He directs a research department comprising 3 Readers, a Senior Lecturer, technicians, and academic staff, with facilities for biochemistry, molecular biology, tissue culture, and advanced imaging. The team investigates neurodegenerative disorders including Parkinson's, Huntington's, and Friedreich's ataxia.

Ning Chengمشاهده پروفایل

استادیار

• Neurodevelopmental Disorders
• Autism Spectrum Disorder
• Fragile X Syndrome
• +۵ مورد دیگر

Ning Cheng is an Assistant Professor (Teaching & Research) at the University of Calgary's Faculty of Veterinary Medicine, with affiliations to the Alberta Children's Hospital Research Institute (ACHRI) and Hotchkiss Brain Institute (HBI). Their research focuses on neurodevelopmental disorders, particularly autism and Fragile X Syndrome, using rodent models to investigate mechanisms and develop experimental therapeutics. PhD in neuroscience from Johns Hopkins School of Medicine Postdoctoral work on neurological disorders at NIH Research spans molecular mechanisms, neural circuitry, and translational approaches to address social, communication, and behavioral challenges in autism spectrum disorders. The lab utilizes in vivo recording/modulation of brain activity, biochemical analyses, and multidisciplinary collaborations. Recent publications highlight expertise in EEG biomarker discovery, auditory processing abnormalities, ketogenic diet interventions, and ERK pathway modulation in mouse models of neurodevelopmental conditions. Key technologies developed include wireless cortical hemodynamic monitoring systems (TinyIOMS) and open-source electrophysiology tools (OSERR). As part of ACHRI's Precision Medicine & Disease Mechanisms program and HBI's Neurodevelopment/SCNIP strategic initiatives, Cheng contributes to university-wide efforts in Brain and Mental Health (2015-2021) and Child Health and Wellness (2020-2025).

Courtney Dumontمشاهده پروفایل

دانشیار

• Neural Stem Cell Biology
• Biomaterials
• Spinal Cord Injury Repair
• +۳ مورد دیگر

Courtney Dumont is an Associate Professor in the Biomedical Engineering department at the College of Engineering , University of Miami. Her research focuses on neural stem cells and tissue-engineered microenvironments to repair nervous system injuries. Education: Not explicitly detailed in the text. Dr. Dumont’s recent publications highlight a multidisciplinary approach combining nanotechnology , biomaterials , and gene therapy to address neurological injuries. Her work spans spinal cord repair , anti-inflammatory strategies , and innovative treatments for SARS-CoV-2 . Key trends in her research include precision nanoparticle delivery systems , engineered scaffolds for cell transplantation , and modulating oxidative stress and inflammation to enhance regeneration. These studies emphasize the integration of biomaterial design with cell and gene therapies for clinical translation. Her lab, the NeuSTEM Research Group , develops multichannel bridges and hydrogel substrates to improve axon regeneration , myelination , and neuronal integration in rodent models.

Joshua Rosenthalمشاهده پروفایل

پژوهشگر

• RNA Editing
• Molecular Biology
• Neurobiology
• +۷ مورد دیگر

Joshua Rosenthal is a Senior Scientist at the Marine Biological Laboratory (MBL), affiliated with the University of Chicago. His research focuses on RNA editing, molecular biology, and neurobiology, particularly processes that modify genetic information in nucleic acids. He leads the Rosenthal Lab and is at the forefront of developing genetically tractable cephalopod models using CRISPR technology. Educational Background Biology B.A., Haverford College Biology Ph.D., Stanford University Dr. Rosenthal's work centers on A-to-I RNA editing via ADAR enzymes, a mechanism that allows precise single-base modifications in mRNA. His lab discovered unprecedented levels of mRNA recoding in cephalopods, exploring how environmental cues influence editing and how this could be harnessed for human therapeutics. The Rosenthal Lab develops site-directed RNA editing platforms to correct genetic mutations in diseases like cystic fibrosis, chronic pain, and cancer. They co-founded Korro Bio, a Cambridge MA-based biotech company commercializing RNA editing therapies. The lab also investigates structural and functional connectivity of squid chromatophores, revealing novel chromogenic behaviors in open-ocean species. Scientific contributions include 11 recent publications on RNA editing mechanisms, cephalopod genetics, and therapeutic applications. Research spans transcriptome plasticity, enzyme targeting, and marine organism adaptation.

• Neuroendocrinology
• Thyroid Hormone Signaling
• Brain Development
• +۴ مورد دیگر

Federico Salas-Lucia is an Assistant Professor in the Department of Medicine, Division of Endocrinology at the University of Chicago's Pritzker School of Medicine. His research integrates neurobiology and endocrinology to investigate thyroid hormone mechanisms in brain development and function, utilizing human iPSC-derived models, transgenic mice, and multi-omics approaches. His educational background includes a BS in Biology from the University of Alicante (2012), an MSc in Neuroscience from University Miguel Hernandez (2014), and a PhD in Neuroscience from the same institution (2018). Dr. Salas-Lucia's research focuses on intracellular mechanisms customizing thyroid hormone action during human brain development. His laboratory examines how thyroid hormones regulate bioenergetic processes supporting neurogenesis, with emphasis on mitochondrial function in neural progenitor cells and epigenetic regulation via DNA methylation. Using cutting-edge iPSC-derived cerebral organoids and advanced imaging, his work bridges molecular mechanisms to clinical correlations between maternal thyroid levels and neurodevelopmental outcomes. Current investigations include thyroid hormone transport via MCT8, deiodinase activity (DIO2/DIO3), and nuclear receptor signaling in neural cells. His publication portfolio since 2018 shows accelerating productivity, with 23 publications through 2025 (8 in 2023 alone). The research demonstrates strong thematic continuity in thyroid-brain interactions , evolving from foundational rodent studies to sophisticated human iPSC models. Recent work increasingly incorporates multi-omics approaches and addresses clinical implications for disorders like Allan-Herndon-Dudley syndrome and Alzheimer's disease. Emerging Group Leader Award, International Society for Neurochemistry (2025) As principal investigator of the Salas-Lucia Laboratory, he directs research on thyroid hormone signaling in neural development. His work receives significant attention, with publications referenced in clinical guidelines and covered by multiple news outlets. The laboratory maintains active collaborations with leading endocrinology researchers including Antonio Bianco and Samuel Refetoff, and participates in interdisciplinary networks exploring metabolic regulation and neurodevelopment. Current projects investigate epigenetic mechanisms in thyroid-mediated cortical development and therapeutic strategies for thyroid hormone transport disorders.

Katherine Newhallمشاهده پروفایل

استاد

• Applied Mathematics
• Stochastic Differential Equations
• Dynamical Systems
• +۵ مورد دیگر

Katherine Newhall is a Professor in the Department of Mathematics at the University of North Carolina at Chapel Hill, where she maintains an active research program in stochastic modeling and dynamical systems. Her office is located in Phillips Hall 308, and she can be reached at knewhall@unc.edu. She serves as a member at large of the GSNP (Group on Statistical and Nonlinear Physics) board, a position she assumed in April 2024. Dr. Newhall earned her educational credentials from Rensselaer Polytechnic Institute, including a B.S. in Applied Physics and Applied Mathematics (2004), an M.S. in Mechanical Engineering (2006) with thesis entitled 'Turbulent Boundary Layers: A look at Skin Friction, Pressure Gradient and Surface Roughness,' and a Ph.D. in Mathematics (2011) with dissertation 'Synchrony in Stochastically-Driven Neuronal Network Models.' Following her doctoral work, she completed postdoctoral research at New York University's Courant Institute of Mathematical Sciences from 2011 to 2014. Her research focuses on developing new tools for analyzing large and infinite dimensional stochastic systems to understand large-scale and long-time dynamics of physical and biological systems. Rather than relying on traditional Fokker-Planck formulations that become intractable with increasing complexity, her work builds on concepts of statistical mechanics to create macroscopic descriptions from individual unit statistics. This approach extends the usefulness of energy landscapes even in non-gradient systems, enabling explanations of experimentally observable phenomena while exposing fundamental mechanisms responsible for system behavior. Her work spans applications from granular materials and chromosome dynamics to biological systems and metamaterials. Dr. Newhall's publications demonstrate consistent advancement in stochastic modeling techniques, with recent work (2023-2025) focusing on hyperuniformity in biological structures, energy landscape sampling methods, and the role of weak transient interactions in biological systems. Her research shows a clear trajectory from fundamental mathematical developments toward increasingly sophisticated biological applications. Outstanding Referee of the Physical Review journals (2019) NSF grant DMS-1816394 DMREF grant ($2M NSF Grant to Revolutionize Materials, 2023) Member at large of the GSNP board (2024) Dr. Newhall has successfully mentored numerous PhD students to completion, including Anna Coletti (2024), Daftari (2023), Moakler (2021), Ben Walker (2021), and Yuan Gao (2019). Her research is consistently supported by competitive grants, most notably the $2M NSF DMREF grant awarded in 2023. She maintains active collaborations across disciplines, particularly in applying mathematical techniques to biological problems such as chromatin organization and organ transplantation risk assessment. Her laboratory work focuses on developing computational methods for analyzing complex stochastic systems, with particular emphasis on the hydra string method for exploring high-dimensional potential energy surfaces. The research group maintains strong connections with both theoretical and experimental collaborators working on granular materials, chromosome dynamics, and biological systems.

Robert Reenanمشاهده پروفایل

استاد

• Aging
• ALS
• Alzheimer's Disease
• +۱۰ مورد دیگر

Dr. Robert Reenan is a Professor of Biology at Brown University, affiliated with the Department of Molecular Biology, Cell Biology, and Biochemistry. His research spans evolutionary genetics, RNA editing, and neurogenetics, focusing on how genomes regulate rapid signaling in the brain through mechanisms like RNA editing and comparative genomics. He has contributed extensively to understanding RNA editing’s role in diseases such as ALS, Alzheimer’s, and epilepsy. Education: PhD in Genetics (Harvard Medical School, 1991), AB in Biology (University of Missouri, 1984) Research Interests: Dr. Reenan investigates RNA editing, ion channels, neurogenetics, and their implications in aging, neurological disorders, and evolutionary adaptation. His work reveals how RNA editing modulates gene function in Drosophila, impacting diseases like ALS and epilepsy. Grants & Collaborations: He has secured major grants from the ALS Association, NIH (NINDS), Ellison Medical Foundation, and NSF. Collaborations include partnerships with researchers like Stephen Helfand, Gary Wessel, and Louis Lapierre. Teaching: Dr. Reenan teaches courses in genetics, molecular genetics, neurogenetics, and scientific communication.

Ryoma Hattoriمشاهده پروفایل

استادیار

• Reinforcement Learning
• Decision Making
• Number Sense
• +۴ مورد دیگر

Ryoma Hattori is an Assistant Professor at the University of Florida, based at the UF Scripps Biomedical Research campus in Jupiter, FL. His laboratory, the Hattori Lab, focuses on neural mechanisms underlying cognitive functions, learning, and their disruption in autism. Dr. Hattori received his educational degrees from prestigious institutions: Ph.D. in Molecular and Cellular Biology from Harvard University (2016) A.M. in Molecular and Cellular Biology from Harvard University (2012) B.S. in Biophysics and Biochemistry from the University of Tokyo (2010) His research interests center on decision making, reinforcement learning, and number sense, using systems and computational approaches. The lab employs techniques such as in vivo 2-photon imaging, optogenetics, virtual reality behaviors, and machine learning to investigate neural activity and plasticity dynamics in mice. A significant focus is understanding how these processes are impaired in autism spectrum disorder. Analysis of his recent publications reveals a strong emphasis on computational neuroscience and neural circuit mechanisms. His work spans from developing advanced imaging and analysis tools to uncovering fundamental principles of value coding and meta-reinforcement learning, with applications in both basic neuroscience and artificial intelligence. Dr. Hattori has received numerous scientific awards, including: Outstanding Mentor Award 2025 from Society of Research Fellows, UF Scripps SFARI Bridge-to-Independence Award 2022-Current from Simons Foundation Warren Alpert Distinguished Scholar Award 2021-2024 from Warren Alpert Foundation Postdoctoral Grant Award 2021-2022 from The KANAE Foundation And several fellowships during his postdoctoral and graduate training. As a principal investigator, Dr. Hattori leads multiple active grants, including the Shenoy Undergraduate Research Fellowship in Neuroscience (2025-2026) and a project on "Neural activity and plasticity dynamics for reinforcement learning in autism" funded by the Simons Foundation. His mentorship has been recognized with the Outstanding Mentor Award. The Hattori Lab is a dynamic research group utilizing cutting-edge technologies to explore the neural basis of cognition, with a particular interest in translational implications for autism and related disorders.

• Neuroscience
• Diabetes
• Molecular Biology
• +۵ مورد دیگر

Sarah A Stanley, MBBCh, PhD is a faculty member at the Icahn School of Medicine at Mount Sinai, where she leads the Stanley Laboratory. Her research spans multiple disciplines at the intersection of neuroscience, diabetes, and molecular biology, with significant contributions to understanding the neuroendocrine regulation of metabolism. Education: BA, University of Cambridge BChir, University of Cambridge MB, University of Cambridge PhD, Imperial College, London University Dr. Stanley's research focuses on three primary areas: pioneering the use of radio waves and magnetic fields to stimulate individual cells and neurons (radiogenetics and magnetogenetics); developing nanoparticles in bioengineered murine models for preclinical applications; and advancing understanding of the interaction between central and peripheral systems in appetite control and diabetes. Her work represents a unique integration of engineering approaches with fundamental neuroscience and metabolic research. Her publications demonstrate a strong trajectory in neuroendocrine research with applications to diabetes treatment, showing increasing sophistication in techniques from molecular biology to advanced neural modulation approaches. The research shows particular strength in translating basic science discoveries into potential therapeutic applications. Scientific Awards: 2016 Alexander and Alexandrine Sinsheimer Scholar Award 2016 Dr. Harold and Golden Lamport Research Award 2015 Cell Symposia: Engineering the Brain International Travel Award Darwin Prize in Experimental Natural Sciences Arthur Burrows Prize (Dermatology) James Anderson Prize (Medicine and Surgery) Dr. Stanley's laboratory is currently funded by The National Institutes of Health and American Diabetes Association, working in close collaboration with colleagues across Mount Sinai and partnerships with Professor Jeffrey Friedman at Rockefeller University and Professor Jonathan Dordick at Rensselaer Polytechnic Institute. Her research program demonstrates strong institutional support and strategic collaborations that enhance the impact of her work. The Stanley Laboratory operates across multiple facilities at Mount Sinai, including locations in the Annenberg Building and Atran Berg Laboratory Building, reflecting the interdisciplinary nature of her research that bridges neuroscience, engineering, and metabolic medicine.

Jesse R. Dixonمشاهده پروفایل

دانشیار

• Chromatin structure
• 3D genome organization
• Gene regulation
• +۴ مورد دیگر

Jesse R. Dixon, M.D., Ph.D., is an Associate Professor at the Gene Expression Laboratory of the Salk Institute for Biological Studies in La Jolla, California. His research explores 3D genome architecture, chromatin organization, and gene regulation mechanisms, with implications for cancer and developmental disorders. He employs cutting-edge genomic technologies like Hi-C and single-cell multi-omics to investigate how chromosomal rearrangements impact gene expression. Dr. Dixon's work focuses on: Topological Domains (TADs) and their role in enhancer-promoter communication Haplotype phasing using chromatin conformation data Structural variant-driven oncogene activation in cancer Single-cell mapping of chromatin and DNA methylation dynamics His publications consistently demonstrate innovations in 3D genome analysis, particularly in neurobiology and oncology contexts, with recurring themes of chromatin topology, epigenetic regulation, and computational genomics. Awards & Honors: Pew Biomedical Scholar (2024) Helmsley Salk Fellow He mentors graduate and postdoctoral researchers in genomics and computational biology, with current projects on chromatin dynamics in cancer and development. The Dixon Lab actively develops novel methodologies for studying genome architecture.

Yang-Hee Kimمشاهده پروفایل

استاد

• Neuroscience
• Neurotoxicity
• Brain Injury
• +۷ مورد دیگر

Yang-Hee Kim is a Professor in the Department of Integrative Bioscience and Biotechnology at Sejong University, South Korea, with a distinguished research career focusing on neuroscience and neurodegenerative diseases. Previously, they served as Associate Professor (2008-2015) and Assistant Professor (2004-2008) in related departments at Sejong University, and held a visiting professorship at Sanford-Burnham Medical Research Institute (2009-2010). Dr. Kim's educational background includes: Ph.D. from Seoul National University (2000) M.S. from Seoul National University (1995) B.S. from Yonsei University (1992) Research interests center on the role of zinc in neurological disorders: Mechanisms of zinc-mediated neurotoxicity in acute brain injury Zinc-induced enhancement of autophagic flux and lysosomal function Development of novel therapeutics for stroke and neurodegenerative conditions Dr. Kim's research has significantly advanced understanding of zinc neurotoxicity, lysosomal function in neurodegeneration, and therapeutic development for conditions like stroke and ALS. With an h-index of 25 and over 1,977 citations, their work demonstrates substantial impact in the neuroscience field. Recent publications (2022-2024) continue to explore zinc biology, lysosomal function, and potential therapeutic applications. Dr. Kim currently serves as CTO of Zincure Corp (2020-present), translating research findings into clinical applications for neurological disorders.

Wen Luمشاهده پروفایل

استادیار

• Cytoskeleton
• Developmental Biology
• Neurobiology
• +۴ مورد دیگر

Wen Lu, PhD is a Research Assistant Professor in the Department of Cell and Developmental Biology at Northwestern University's Feinberg School of Medicine. Her primary research focuses on cytoskeletal regulation and molecular motor coordination in super-large cells including oocytes and neurons, utilizing Drosophila melanogaster as a model organism. She employs high-resolution live microscopy, genetic engineering, optogenetics, and pharmacological manipulations to investigate microtubule and F-actin dynamics in cellular development and regeneration. Her educational background includes a BS from Peking University (2004) and a PhD from The University of Chicago (2010), followed by postdoctoral training at Northwestern University Feinberg School of Medicine. Dr. Lu maintains active affiliations with the American Society for Cell Biology (2019-2024) and the Genetics Society of America (2022-2023), and serves on the FlyBase Community Advisory Group since 2014. Research interests center on cytoskeletal dynamics in cellular polarization, with particular emphasis on oocyte specification, growth mechanisms, and neuronal regeneration after injury. Her work bridges developmental biology and neurobiology through innovative imaging techniques that reveal molecular transport mechanisms in cellular systems. Current investigations explore microtubule movement regulation and the interplay between cytoskeletal elements during critical developmental processes. Publication trends demonstrate strong interdisciplinary focus spanning cell biology, neurobiology, and imaging sciences, with recent work increasingly incorporating translational elements in ophthalmology and oncology. Her articles reveal consistent methodological innovation in live-cell imaging and genetic manipulation techniques applied to fundamental biological questions. Winner 2025 Drosophila Art Contest, The FlyStuff / Genesee Scientific Team Winner of CDB Graphic Design Contest, CDB Special Events Committee (2024) Winner in Category 2, Microscopy Image Competition 2024, ProteinTech Group 2nd Prize in Published Category, Microscopy Today Micrograph Awards (2024) BINA 2022 Image Contest- People's Choice Award, BioImaging North America Dr. Lu serves on the FlyBase Community Advisory Group and maintains industry relationships including ownership in Quantum Music LLC. Her laboratory work integrates advanced microscopy with genetic models to address fundamental questions in cellular organization, with potential implications for understanding developmental disorders and neurodegenerative conditions.

Christoph Handschinمشاهده پروفایل

استاد

• Skeletal Muscle Biology
• Exercise Physiology
• Aging and Age-Related Diseases
• +۴ مورد دیگر

Christoph Handschin is a Full Professor in Pharmacology at the Biozentrum, University of Basel, Switzerland , with a research focus on skeletal muscle plasticity, aging, and metabolic diseases since 2015. He leads a research group investigating molecular mechanisms of muscle adaptation to physiological and pathophysiological conditions. Education: PhD in Biochemistry (summa cum laude, 2001), MSc in Molecular Biology (1996), Voluntary training at Novartis (1992) Research Interests span skeletal muscle biology, aging, exercise physiology, neuromuscular diseases, and metabolic disorders. His work emphasizes PGC-1α signaling, mitochondrial dynamics, and chromatin remodeling in muscle adaptation. Recent studies explore exercise-induced chromatin changes, biomarkers of aging, and dysferlinopathy mechanisms. Key Scientific Awards include the ERC Consolidator Grant (2013) , SNSF Professorship (2006) , and MDA Scientist Career Development Award (2004) . He is a member of the American Physiological Society and European Association for the Study of Diabetes. Recent Articles highlight breakthroughs in chromatin accessibility , functional aging biomarkers , dysferlinopathy metabolism , and PGC-1α-driven muscle adaptations . His research bridges molecular mechanisms (e.g., Klf5, PER2) with systemic physiology (e.g., exercise performance, sarcopenia).

John Manakمشاهده پروفایل

استاد

• Genetics
• Neurobiology
• Genomics

John Manak serves as Professor and Biomedical Sciences Program Director in the Department of Biology at the University of Iowa, conducting research at the intersection of genomics, genetics, and neurobiology. His work employs model organisms including Drosophila and Xenopus to investigate human genetic disorders and develop translational therapies. His academic background includes: PhD from Columbia University Dr. Manak's research focuses on identifying causative mutations for congenital anomalies such as spina bifida, branchio-oto-renal syndrome, renal agenesis, and cleft lip/palate. His lab discovered ISM1 as a critical craniofacial patterning gene and elucidated PRICKLE's role in epilepsy-ataxia syndromes using fly models. Current work explores glial immune responses and oxidative stress pathways in seizure progression, with potential for repurposing anti-inflammatory drugs as novel anti-epileptic therapies. Analysis of his 2019-2023 publications reveals consistent emphasis on copy-number variation analysis in craniofacial disorders and epilepsy mechanisms. Key trends include identification of novel clefting genes (COBLL1, RIC1, ARHGEF38), chromatin organization studies involving Dm-Myb, and translational approaches targeting neuroinflammation. His work bridges fundamental genetic discovery with clinical applications through integrated genomic and physiological analyses. No scientific awards were specified in the source material. As principal investigator, Dr. Manak mentors graduate students and postdoctoral researchers while securing research funding evidenced by his publication record in high-impact journals including Nature, PNAS, and Cell Reports. His leadership extends to directing the Biomedical Sciences Program and contributing to departmental research initiatives. His laboratory maintains active research programs utilizing Drosophila for epilepsy modeling, Xenopus for craniofacial studies, and mammalian systems for neuroprotection research. The lab collaborates extensively with University of Iowa core facilities including the Carver Center for Genomics and Carver Center for Imaging, employing techniques ranging from CRISPR-based gene editing to electrophysiological analysis of neural circuits.